I don't know if anyone has posted this elsewhere?
https://www.theguardian.com/science...erm=241279&subid=20221326&CMP=EMCNEWEML6619I2
https://www.theguardian.com/science...erm=241279&subid=20221326&CMP=EMCNEWEML6619I2
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Anti-inflammatory injections could lower the risk of heart attacks and may slow the progression of cancer, a study has found, in what researchers say is the biggest breakthrough since the discovery of statins.
Heart attack survivors given injections of a targeted anti-inflammatory drug called canakinumab had fewer attacks in the future, scientists found. Cancer deaths were also halved in those treated with the drug, which is normally used only for rare inflammatory conditions.
Statins are the mainstay drugs for heart attack prevention and work primarily by lowering cholesterol levels. But a quarter of people who have one heart attack will suffer another within five years despite taking statins regularly. It is believed this is because of unchecked inflammation within the heart’s arteries.
The research team, led from Brigham and Women’s hospital in Boston, tested whether targeting the inflammation with a potent anti-inflammatory agent would provide an extra benefit over statin treatment.
https://en.wikipedia.org/wiki/CanakinumabCanakinumab (INN, trade name Ilaris, previously ACZ885)[2] is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.[3]
Canakinumab was approved for the treatment of cryopyrin-associated periodic syndromes (CAPS) by the U.S. Food and Drug Administration (FDA) in June 2009[4] and by the European Medicines Agency in October 2009.[5] CAPS is a spectrum of autoinflammatory syndromes including familial cold autoinflammatory syndrome, Muckle–Wells syndrome, and neonatal-onset multisystem inflammatory disease. In September 2016, FDA approved the use of canakinumab on 3 additional rare and serious auto-inflammatory diseases:[6] Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS), Hyperimmunoglobulin D Syndrome (HIDS)/Mevalonate Kinase Deficiency (MKD) and Familial Mediterranean Fever (FMF).
That's in the US, right? What would be the cost of this drug in the UK? I'm not sure of the magnitude of the US markup on drugs. I seem to recall its pretty huge (especially for drugs whose cost may include special medical services like infusions).The cost of one dose is ~$10000
That's in the US, right? What would be the cost of this drug in the UK? I'm not sure of the magnitude of the US markup on drugs. I seem to recall its pretty huge (especially for drugs whose cost may include special medical services like infusions).
Interestingly, this would also lower the price for those with rare diseases too.article said:Novartis recently discovered that a drug it sells for a group of very rare diseases could be used to treat a much more common ailment. There is just one problem: its $US16,000-per-dose ($A21,000) price tag.
The drug, called ACZ885, is already sold under the brand name Ilaris for certain rare inflammatory disorders affecting a very small number of people. But a recent clinical trial suggests it could also reduce the risk of serious complications like strokes in people who have suffered a heart attack.
If the drug does pan out with regulators, Novartis would have to drastically cut its price to make it competitive with other cardiovascular drugs. That would mean jettisoning a small, but reliable, revenue stream on an uncertain bet that the drug could become a top seller as a cardiovascular medicine.
But a quarter of people who have one heart attack will suffer another within five years despite taking statins regularly.
Canakinumab (INN, trade name Ilaris, previously ACZ885)[2] is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.[3]
That's in the US, right? What would be the cost of this drug in the UK? I'm not sure of the magnitude of the US markup on drugs. I seem to recall its pretty huge (especially for drugs whose cost may include special medical services like infusions).