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Does anyone following this entry experience symptomatic relief after ingesting acute alcohol? If so can you please let me know I have a few questions. I am preparing to release another entry that I think will be fairly significant.
The hypothesis of a metaflammasome is based on the concept that failure of endoplasmic reticulum function (due to accumulation of newly synthesized unfolded proteins) results in the activation of an unfolded protein response and upregulated inflammation [30]. Our data in part appear to support this concept as in AD the accumulation of Aβ and Tau might lead to an unfolded protein response and inflammation, hence precipitating neurodegeneration.
Also wouldnt mind hearing this theory. I have tried androsterone as put forth by @Tunguska a few times at very small doses along with low dose dhea and Ive found this to reliably be a great combo for me at least. I will have to keep experimenting more with it to see if it is able to be good in the long term. Idk if this is due to the FXR receptor or simply the neuro-anti inflammatory effects of these androgens, but they definitely help--in a low dose
I am not familiar with this theory. I am more than happy to look into this. What sort of symptom relief do you experience when taking this?
If you look earlier in the thread its proposed that androsterone has effects on the FXR recepto, so thats what initially peeked my interest in it..Keep in mind its only been a couple weeks.. But I started using the combo during a pretty nasty "crash", where I couldnt sleep even though my body was exhausted my brain just wouldnt shut off, brain freaking out, couldnt tolerate noises or light. It didnt totally fix this but it makes the sleep I do get much more repairing. I guess thats the best way to describe it- it feels like it shifts the body from total survival freak out mode into a more calm, repairing mode.
The first day after I took the andro I had more and healthier bowel movements. Appetite increase, sense of being more in touch with reality, my brain feels very much calmed down, less overall pain, and m complexion seems to have changed( I look somewhat healthy lol) I am taking it very slow, I only dose once every 2-3 days and in much smaller doses than people normally take of this stuff, but so far its been extremely effective with little to no downsides.
What form are you taking the andro? Sounds as though it caused a shift in nervous system activity. It maybe boosting the function of one of your digestive organs. I'm not sure that long term this will continue to be honest. I have not seen great things happen with pro-hormones.
Its a transdermal type of delivery. Im using oral dhea with it in doses of 2-3 mg..You could be correct, but for now I will take the symptom relief. Im hoping by only usig a couple times a week and tiny dose that there wont be much acclimation. It certainly -feels- like it does something very good for the digestive system, which has been a huge source of problems for me throughout this whole thing. Ive been on testosterone before early on in the illness and that both helped and hurt me I think, but this combination feels much different than that.
Its a transdermal type of delivery. Im using oral dhea with it in doses of 2-3 mg..You could be correct, but for now I will take the symptom relief. Im hoping by only usig a couple times a week and tiny dose that there wont be much acclimation. It certainly -feels- like it does something very good for the digestive system, which has been a huge source of problems for me throughout this whole thing. Ive been on testosterone before early on in the illness and that both helped and hurt me I think, but this combination feels much different than that.
"It now turns out that androsterone does activate a nuclear receptor: FXR. These data are in line with those from another study reporting that androsterone up-regulates FXR-mediated transactivation in an in vitro cis/trans assay (14). In the present issue, the authors determined also whether the expression of the small heterodimer partner (SHP), another nuclear receptor and well-characterized FXR target gene, is regulated by androsterone. They show that the treatment of castrated male mice or mouse AML-12 hepatocytes with androsterone indeed induces SHP mRNA expression, suggesting that androsterone increases the activity of mouse FXR. Using nuclear magnetic resonance spectroscopy technology, the authors show that androsterone directly binds to the ligand binding domain of human FXR. This binding leads to the simultaneous recruitment of the coactivator peptide steroid receptor coactivator-1."
https://academic.oup.com/endo/article/147/9/4022/2528306/FXR-More-than-a-Bile-Acid-Receptor
Its hard to say definitively that this is whats giving you symptom relief but it does seem that andro has a clear impact on FXR activity. This study was done on mice.