Jesse2233
Senior Member
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TL;DR
Has anyone tested positive for A1 autoantibodies and successfully reduced symptoms (OI or otherwise) using A1 agonists?
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I recently tested positive through CellTrend for A1 autoantibodies (and no other ones save for being at risk on M4). This led me to a rabbit hole of research into potential treatments I've not seen widely discussed here.
The A1 (alpha-1 adrenergic) receptor primarily mediates smooth muscle contraction (vasoconstriction) via the central and peripheral nervous system. Autoantibodies against this receptor have been implicated as a causal factor in one POTS study (1) and identified as a CFS/ME subset in another (2).
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Readily available A1 agonists
Has anyone tested positive for A1 autoantibodies and successfully reduced symptoms (OI or otherwise) using A1 agonists?
--------------
I recently tested positive through CellTrend for A1 autoantibodies (and no other ones save for being at risk on M4). This led me to a rabbit hole of research into potential treatments I've not seen widely discussed here.
The A1 (alpha-1 adrenergic) receptor primarily mediates smooth muscle contraction (vasoconstriction) via the central and peripheral nervous system. Autoantibodies against this receptor have been implicated as a causal factor in one POTS study (1) and identified as a CFS/ME subset in another (2).
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Readily available A1 agonists
- Midodrine (antihypotensive) - Oral Rx common in first line POTS treatment
- Butchers broom (herbal) - Oral OTC supplement derived from the Ruscus aculeatus plant
- Phenylephrine (decongestant) - Oral OTC as Sudafed PE, have seen good anecdotal results
- Pseudoephedrine (decongestant) - Oral OTC as Sudafed (old formula)
- Naphazoline (decongestant) - Eye drops OTC, Rx strength (0.10%) used by Dr Jay Goldstein
- Oxymetazoline (decongestant) - Nasal spray OTC found in Sudafed OM, Vicks Sinex, and Zicam
- Tetrahydrozoline (decongestant) - Eye drops OTC, found in Visine and the movie Wedding Crashers
- Xylometazoline (decongestant) - Nasal spray OTC used to improve symptoms of nasal congestion
- Synephrine (mild vasoconstrictor) - Alkaloid found in citrus fruits and various sups / pharamceduals
- Etilefrine (antihypotensive) - IV Rx for orthostatic hypotension of multi-system origin
- Metaraminol (antihypotensive) - IV RX used in the prevention and treatment of hypotension
- Cirazoline (vasoconstrictor) - Research compound and full A1 agonist
- Methoxamine (vasoconstrictor) - Discontinued oral Rx