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Several studies, including the last big cytokine study from Stanford, has found elevated TGF-beta in PwME. According to this article, TGF-beta is central in the interactions of the gut microbiota and immune system.
http://www.nature.com/cti/journal/v6/n4/full/cti20179a.html
Largely overlooked until the last decade, the interplay between the microbiota and the mammalian host organism is now widely regarded as essential for host homeostasis and health. In this review, we have highlighted the complexity of this interplay within the gut and the central role of TGF-β in regulating these interactions. TGF-β levels in the gut are directly and indirectly modulated by the gut microbiota, which impacts the development and functions of immune cell subsets, which in turn regulates microbiota sequestration within the mammalian lumen.
http://www.nature.com/cti/journal/v6/n4/full/cti20179a.html