Had you your blood Calcidiol and Calcitriol checked, it seems that low levels are associated with POTS:
1-α hydroxylation defect in postural orthostatic tachycardia syndrome: Remission with calcitriol supplementation
Article · August 2012 with 27 Reads1st
Shilpa Chaudhari 2nd
Alan Sacerdot 3rd
Gul Bahtiyar
Abstract
A 37-year-old woman presented with a history of reactive hypoglycaemia, non-classic adrenal hyperplasia (NCAH), osteopenia and fibromyalgia. After several months of palpitations, postural orthostatic tachycardia syndrome (POTS) was diagnosed by tilt table studies. Her heart rate (HR) reached 191 bpm at 60 degrees from horizontal. Investigation suggested increase in epinephrine and norepinephrine levels in response to tilt table. Her 25(OH) vitamin D level measured by immunoextraction radioimmunoassay was 35 pg/ ml (normal 9-54 pg/ml) while her 1,25(OH)(2) vitamin D3 level was 24 pg/ml (normal 30-67 pg/ml). Accordingly, she was started on calcitriol 0.25 mcg orally daily. At her next visit after 5 months, she reported remarkable improvement in her palpitations and had been working full time for the past 4 months. HR both seated and upright was 72 bpm. After 3 months, her 1,25(OH)(2) vitamin D3 level on calcitriol was 40 pg/ml. The authors suggest that 1-α hydroxylation defects should be sought and treated, if present, with calcitriol in patients with POTS.
Acta Neurol Scand. 2015 Oct;132(4):242-50. doi: 10.1111/ane.12390. Epub 2015 Feb 24.
Vitamin D deficiency in Parkinson's disease patients with orthostatic hypotension.
Jang W1,
Park J2,
Kim JS3,
Youn J4,
Oh E5,
Kwon KY6,
Jo KD1,
Lee MK1,
Kim HT7.
Author information
Abstract
OBJECTIVES:
The purpose of our study was to investigate the associations between serum vitamin D3 levels and orthostatic hypotension (OH) in patients with Parkinson's disease (PD).
MATERIALS AND METHODS:
Fifty-five patients with PD were enrolled in this study. Blood pressure (BP) measurements were gathered while the patients were in the supine position and while standing up. Then, the patients were divided into two groups: PD patients with and without OH. We compared the levels of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 (calcitriol) between the two groups.
RESULTS:
Serum 25-hydroxyvitamin D and calcitriol levels were significantly decreased in patients with OH compared with those without OH. The systolic and diastolic BPs and symptom severities significantly negatively correlated with the serum 25-hydroxyvitamin D and calcitriol levels.
CONCLUSIONS:
Although the underlying mechanism for this association is not fully understood, our results suggest that low vitamin D status is associated with OH in patients with PD.