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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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@ScottTriGuy - This is a great compendium of studies! Did you put this together?
Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome
http://pubs.rsna.org/doi/abs/10.1148/radiol.14141079
https://med.stanford.edu/news/all-n...bnormalities-in-chronic-fatigue-patients.html
EEG spectral coherence data distinguish chronic fatigue syndrome patients from healthy controls and depressed patients-A case control study
https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-82
I do wonder how many studies can truly be considered seminal if they haven't been repeated elsewhere?
Most of them haven't been directly replicated, due to reasons of funding mostly.
The ones that come closest are GET/CBT studies, but replication doesn't do much if you start out with a biased trial design.
I do wonder how many studies can truly be considered seminal if they haven't been repeated elsewhere?
@JaimeS great project, thanks for all your work! Apologies if you've already considered these...NK cell work has been repeated like crazy. Got to get at least one of those in there.
https://www.ncbi.nlm.nih.gov/pubmed/24456560 seems to be one, though I'm unsure how seminal it is.Are there any seminal studies effectively demonstrating "ME is not deconditioning" ?
CONCLUSION:
Low oxygen uptake by muscle cells causes exercise intolerance in a majority of CFS patients, indicating insufficient metabolic adaptation to incremental exercise. The high increase of the cardiac output relative to the increase of oxygen uptake argues against deconditioning as a cause for physical impairment in these patients.
The lack of any significant differences between groups for the first exercise test would appear to support a deconditioning hypothesis for CFS symptoms. However, the results from the second test indicated the presence of CFS-related postexertion fatigue. It might be concluded that a single exercise test is insufficient to reliably demonstrate functional impairment in people with CFS. A second test might be necessary to document the atypical recovery response and protracted fatigue possibly unique to CFS, which can severely limit productivity in the home and workplace.
I don't understand this first sentence.
@RogerBlack thanks. No I don't understand that first sentence either :thumbdown:
It means that a one-day exercise test can not discriminate between ME patients and deconditioned controls - it takes another exercise test on day 2 to see differences between the groups.
when according to the deconditioning-symptoms-on-exercise-fear-avoidance hypothesis all patients with long-lasting CFS are in a fear-avoidance-deconditioning loop and therefore should be deconditioned.appear to support a deconditioning hypothesis for CFS symptoms.
Are there any seminal studies effectively demonstrating "ME is not deconditioning" ?
https://www.ncbi.nlm.nih.gov/pubmed/24456560 seems to be one, though I'm unsure how seminal it is.
according to the deconditioning-symptoms-on-exercise-fear-avoidance hypothesis all patients with long-lasting CFS are in a fear-avoidance-deconditioning loop and therefore should be deconditioned.