HRV sleep research and trying to understanding why the body doesn't restore itself in sleep ( an essential part of health)
Severe ME research, especially in the area of vastly reduced brain functioning and energy production and the peculiar sensitivities - why the light sensitivity etc - requiring imaging and probably inpatient facilities
Imaging research to establish issues such as brain circulation deficits, matter atrophy or functioning and connection and signalling deficits
Mitochondria and energy generation research and what's blocking it
Neuro Inflammation explored further and drugs to treat it
Autonomic dysfunction
Further research in the abnormal response of muscles to activity
Much done to effectively subgroup
explore and define PEM and how it Is experienced differently in CFS vs ME vs severe ME
Vagus nerve infection & Explore the possibilities of infection of the CNS
More spinal fluid research to find biomarkers
Gut research - dysbiosis, leaky gut, relation to exertion
Getting exercise harm -exacerbation proved e.g. with VO2 testing etc and prove its not just that it's deconditioning and compare/contrast with other similar illness e.g. MS, sjogrens.
Post mortem research to establish or not neurological issues in the severe
More research of the type the Australians are doing which is very complicated involving IONs and receptors and other stuff beyond me. Probably complex stuff on genes and gene expression, again beyond me.
Establish more on immunity and auto immunity and how it reacts to exertion
Treatment explored as we go along to relieve suffering asap including b12, ampligen, saline, immune drugs, nimodipine
Lots of the above done in studies large enough to include other other groups for contrast e.g. Deconditioned and other illness so we can start to isolate the unique factors of ME and stop having interesting findings such as NK cells being dismissed as non specific or possibly stress related or too small size to be certain etc.
I'm quite impressed that I wrote that in 14 minutes when the UK ME MRC expert group took between 2008 and 2011 and workshops etc to do similar and still left out the severe.