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How do you treat overmethylation?

Fred Smith

Guest
Messages
118
I have been reading on this forum and everyone says different things. what i have been reading is are you supposed to take folic acid, niacin and b12? is this true and what doses?

So how do you treat Histapenia (overmethylation)?
 
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CCC

Senior Member
Messages
457
Your question is too general.

You might want to tell us a bit more about why you have been taking and why. And then why you want to focus on overmethylation.
 

Fred Smith

Guest
Messages
118
Your question is too general.

You might want to tell us a bit more about why you have been taking and why. And then why you want to focus on overmethylation.
I take the 3 i mentioned in the thread for about 2 weeks. thats it. theres really nothing much else to it. all i wanna know what the treatment for overmethylation is.
 

Eastman

Senior Member
Messages
526
@farshad

Exactly what symptoms are you trying to treat? The term "overmethylation" does not mean exactly the same thing to different people.
 

CCC

Senior Member
Messages
457
I take the 3 i mentioned in the thread for about 2 weeks. thats it. theres really nothing much else to it. all i wanna know what the treatment for overmethylation is.
What doses? What forms? Why only those three? What symptoms were you trying to treat? What has happened to make you think you are overmethylating?
 

CFS_for_19_years

Hoarder of biscuits
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2,396
Location
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@farshad, welcome to PR.

Ben Lynch recommends niacin, taken as nicotinic acid, among other things:
http://mthfr.net/methylfolate-side-effects/2012/03/01
  1. Consider 50 to 100 mg of niacin as nicotinic acid. Why? Niacin is broken down by SAMe. This means that excessive SAM is quenched by taking niacin. Niacin also helps transform folates – especially unreduced folates. There are many other things niacin does as well – beyond my understanding. I continue to look for them and will update this as I learn more.
    • NOTE: You may experience flushing for 20 to 30 minutes. This is not harmful. It simply makes you feel ‘warm’ everywhere.
  2. Consider liposomal curcumin to help quench inflammation. If one takes methylfolate before inflammation is controlled, the methylfolate will worsen it. One may consider taking 2 capsules of Optimal Turmeric three times a day during times of inflammation.
  3. Consider Hydroxocobalamin as it is an excellent sponge for reducing nitric oxide levels. Methylfolate increases nitric oxide levels – which is why it is so effective in reducing headaches, pain, cardiovascular disease risk, thrombosis, preeclampsia, periodontal disease, etc – but at the same time, excessive nitric oxide levels are harmful as they end up producing serious radical damage via peroxynitrite. Hydroxocobalamin quenches nitric oxide quite effectively. Hydroxocobalamin also works to reduce hydrogen sulfide levels (great for those with high sulfate-reducing bacteria or sulfur-smelling stools/diarrhea).
  4. Limit intake of leafy greens until side effects go away. This is because leafy green also contain methylfolate and nitrates.
  5. Electrolytes – as methylfolate increases, so does cell division and when that happens, electrolyte deficiency can occur. Taking Optimal Electrolyte helps knock out some of these side effects. There is also some niacin in the electrolyte blend.
  6. Glutathione – as cells divide with more methylfolate, glutathione levels get further depleted. Restoring levels can help significantly. Do it SLOWLY though. Consider Optimal Liposomal Glutathione.
 

Fred Smith

Guest
Messages
118
@farshad, welcome to PR.

Ben Lynch recommends niacin, taken as nicotinic acid, among other things:
http://mthfr.net/methylfolate-side-effects/2012/03/01
I take these 3 are they ok??

https://www.amazon.co.uk/Folinic-Aci...s=folinic+acid

https://www.amazon.co.uk/Veganicity-...1&keywords=b12

https://www.amazon.co.uk/Vitamin-Nia...eywords=niacin

also it says something about methylfolate& methylcobalamin on the link you provided . whats that? is it some other thing i should be taking?
 
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Fred Smith

Guest
Messages
118
What doses? What forms? Why only those three? What symptoms were you trying to treat? What has happened to make you think you are overmethylating?
b12 cyano (5 mg)
niacin flush (100mg)
folinic acid (5mg)
daily

why only those 3? Idont know thats what ihave been seeing mostly said on the net. Im trying to treat fatigue, depression , anxiety, .

I have tries a lot of prescribed medication they didnt work.. I have tried almost everything and overmethylator really fits my description i am very sure about this. my dad also has the same problem as me.
 

Fred Smith

Guest
Messages
118
so if you're an overmethylator you take Glutathione, electrolytes, hydroxo b12, nicotinic acid ?? what about folinic acid? im so confused ;/
 

CFS_for_19_years

Hoarder of biscuits
Messages
2,396
Location
USA
I take these 3 are they ok??

https://www.amazon.co.uk/Folinic-Aci...s=folinic+acid

https://www.amazon.co.uk/Veganicity-...1&keywords=b12

https://www.amazon.co.uk/Vitamin-Nia...eywords=niacin

also it says something about methylfolate& methylcobalamin on the link you provided . whats that? is it some other thing i should be taking?
so if you're an overmethylator you take Glutathione, electrolytes, hydroxo b12, nicotinic acid ?? what about folinic acid? im so confused ;/

I don't know if folinic acid treats overmethylation

This product is methylcobalamin, which is the most popular form of B12, but it is not the type of B12 that will treat overmethylation - see below:
https://www.amazon.co.uk/Veganicity-...1&keywords=b12

The type of B12 you want for overmethylation is hydroxycobalamin:
https://www.amazon.co.uk/Liposomal-Hydroxy-Hydroxocobalamin-Vitamin-Vegan/dp/B01DW1A93Q/ref=sr_1_1_s_it?s=drugstore&ie=UTF8&qid=1493582126&sr=1-1&keywords=hydroxycobalamin b12
or
https://www.amazon.co.uk/ProHealth-Hydroxocobalamin-ExtremeTM-sublingual-tablets/dp/B002SKV61M/ref=sr_1_3_s_it?s=drugstore&ie=UTF8&qid=1493582126&sr=1-3&keywords=hydroxycobalamin b12

Niacin treats overmethylation - it is also known as nicotinic acid:
https://www.amazon.co.uk/Vitamin-Nia...eywords=niacin
 
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Fred Smith

Guest
Messages
118
I don't know if folinic acid treats overmethylation

This product is methylcobalamin, which is the most popular form of B12, but it is not the type of B12 that will treat overmethylation - see below:
https://www.amazon.co.uk/Veganicity-...1&keywords=b12

The type of B12 you want for overmethylation is hydroxycobalamin:
https://www.amazon.co.uk/Liposomal-Hydroxy-Hydroxocobalamin-Vitamin-Vegan/dp/B01DW1A93Q/ref=sr_1_1_s_it?s=drugstore&ie=UTF8&qid=1493582126&sr=1-1&keywords=hydroxycobalamin b12
or
https://www.amazon.co.uk/ProHealth-Hydroxocobalamin-ExtremeTM-sublingual-tablets/dp/B002SKV61M/ref=sr_1_3_s_it?s=drugstore&ie=UTF8&qid=1493582126&sr=1-3&keywords=hydroxycobalamin b12

Niacin treats overmethylation - it is also known as nicotinic acid:
https://www.amazon.co.uk/Vitamin-Nia...eywords=niacin
ok so will these 3 do?
http://www.ebay.co.uk/itm/231605206867
http://www.ebay.co.uk/itm/Folinic-A...216939?hash=item4b13d4232b:g:QN8AAOSwx-9WwciA
http://www.ebay.co.uk/itm/231545364262?var=530788213816

but on the link you provided it says somth about Glutathione, electrolytes and some other stuff what about those? or are these 3 enough.,also whats the difference between the 2 b12 you provided? just one is liquid and the other is capsules?
 
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CFS_for_19_years

Hoarder of biscuits
Messages
2,396
Location
USA
ok so will these 3 do?
http://www.ebay.co.uk/itm/231605206867
http://www.ebay.co.uk/itm/Folinic-A...216939?hash=item4b13d4232b:g:QN8AAOSwx-9WwciA
http://www.ebay.co.uk/itm/231545364262?var=530788213816

but on the link you provided it says somth about Glutathione, electrolytes and some other stuff what about those? or are these 3 enough.,also whats the difference between the 2 b12 you provided? just one is liquid and the other is capsules?

Even just one of those, the niacin alone might work, but I'm not on expert on methylation. I don't think you need all of the products, but I think niacin (nicotinic acid) is the one you should definitely think of getting. Having 3 of the products on hand should cover you pretty well.

The only difference I can see between the two B12's I provided was just the form - one is liquid and one is tablets.
 

Fred Smith

Guest
Messages
118
do I need to take all these supplements?
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Fred Smith

Guest
Messages
118
Even just one of those, the niacin alone might work, but I'm not on expert on methylation. I don't think you need all of the products, but I think niacin (nicotinic acid) is the one you should definitely think of getting. Having 3 of the products on hand should cover you pretty well.

The only difference I can see between the two B12's I provided was just the form - one is liquid and one is tablets.
oh thank you so much. so i will be getting the 3 I linked latest. do you know how long it takes to see improvements? and the thing im wondering are the dosages. cant find anything on it anywhere the doses for overmethylation.. is it high, low or medium doses.. i guess i will have to try it myself and see how i feel.
 

CCC

Senior Member
Messages
457
I'm not sure that overmethylation = too much serotonin.

You say you have fatigue, depression and anxiety.

Maybe read this thread by @Hip

Starting down the methylation trail is challenging, and hip's approach might be easier for you to begin with.
 

Fred Smith

Guest
Messages
118
I'm not sure that overmethylation = too much serotonin.

You say you have fatigue, depression and anxiety.

Maybe read this thread by @Hip

Starting down the methylation trail is challenging, and hip's approach might be easier for you to begin with.
Overmethylation (Histapenia): Too much methyl (a carbon group with three hydrogen atoms). It is very active in the brain, and too much leads to “too much of a good thing.” This causes an overproduction of serotonin, norepinephrine, and dopamine in the brain. In many cases, high serotonin levels can cause psychological problems including reduced motivation, reduced libido, weight gain, and confusion.

http://mentalhealthdaily.com/2015/0...s-overmethylation-causes-symptoms-treatments/

whats so hard to understand?
 

CCC

Senior Member
Messages
457
Overmethylation (Histapenia): Too much methyl (a carbon group with three hydrogen atoms). It is very active in the brain, and too much leads to “too much of a good thing.” This causes an overproduction of serotonin, norepinephrine, and dopamine in the brain. In many cases, high serotonin levels can cause psychological problems including reduced motivation, reduced libido, weight gain, and confusion.

http://mentalhealthdaily.com/2015/0...s-overmethylation-causes-symptoms-treatments/

whats so hard to understand?

It's complex. I understand the bits I need for my son, which are different bits to the bits you need. That article captures only a small bit.

Have you had tests to show high histamine levels etc?

Some people come to this forum having driven themselves into overmethylation by consuming too many supplements that drive the methylation cycles - for example, by taking too much methylfolate or something else that drives the cycle. That's why we're asking questions.

Other people find they can pick symptoms off both lists in your linked articles. Those lists work for a few people, though, so be grateful if you are one of them.
 

Fred Smith

Guest
Messages
118
It's complex. I understand the bits I need for my son, which are different bits to the bits you need. That article captures only a small bit.

Have you had tests to show high histamine levels etc?

Some people come to this forum having driven themselves into overmethylation by consuming too many supplements that drive the methylation cycles - for example, by taking too much methylfolate or something else that drives the cycle. That's why we're asking questions.

Other people find they can pick symptoms off both lists in your linked articles. Those lists work for a few people, though, so be grateful if you are one of them.
my overmethylation is genetics due to a MTHFR mutation. not because i took some medication its just how my body works. if you know something I don't I would appericate if you told me. My dad also has the same problems as me if that will further prove its genetics. You can belive me or not all I wanna know is how you treat this .