ljimbo423
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I'm curious, does Lipkin write about SIBO in this or another study?
I"m not aware of Lipkin writing about SIBO specifically, just an altered microbiome.
to what degree is the small intestine in CFS/ME deranged as opposed to standalone SIBO? I guess I would like to see study like this comparing CFS/ME+SIBO to CFS/ME and SIBO instead of IBS.
I would like to see a study like that also! From all the reading I have done, there are varying degrees of SIBO. Some people can have SIBO and not have any significant degree of leaky gut.
Others can have SIBO and a leaky gut that ranges from mild to severe, with various degrees of bacterial translocation (ie.-LPS). There are of course many factors, that you are probably aware of, that make one more or less vulnerable to the severity of SIBO and a leaky gut.
Many of the triggers of CFS are also known to cause or worsen, SIBO/dysbiosis and a leaky gut. Excessive stress from everyday life, a viral or bacterial infection, a car accident or the loss of a loved one,etc. can have a big impact on the microbiome and a leaky gut.
These triggers might, in some cases, be the straw that broke the camels back, so to speak. Here is paper talking about stress and an altered microbiome.
The composition of the core bacteria that we harbour throughout our adult life is established early in our first few years of life and are shaped by a number of factors including mode of delivery (vaginal or C-section), whether we are breastfed or bottlefed, diet, medication (in particular antibiotic medication), and exposure to viral or bacterial infections and stress (Borre et al., 2014b).
Chronic stress also can cause or worsen a leaky gut -
LINKChronic stress also makes the gut leaky, increasing circulating levels of LPS.
ETA: Thanks for the hesperidin and lps link- I will definitely read!
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