AndyPR
Senior Member
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I think you mean that they have a theory that leaky gut cause inflammation. That's it. They aren't speculating that the issues with the gut are causing ME, which seems to be what you are trying to imply.
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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Xifaxin seemed to help this person somewhat.
I think you mean that they have a theory that leaky gut cause inflammation. That's it. They aren't speculating that the issues with the gut are causing ME, which seems to be what you are trying to imply.
It can also be quite beneficial in humans (...apart from when someone horrid doesn't wash their hands after wiping their bum before making you a lovely home made pie).Weaned piglets E-coli can kill whole litters.
If that's all their theory involves why use a ME/CFS population and why did you (and I) crowd-fund it?
If it's true that LPS is getting into the bloodstream and causing inflammation, that's an avenue for treatment.
Could it perhaps lead to autoantibody production instead?But their own results suggest there's no evidence of elevated cytokines.
https://www.researchgate.net/profil...e_Diseases/links/0046352cae0af3b5df000000.pdfBesides celiac disease, several other autoimmune diseases, including type 1 diabetes [13, 14], multiple sclerosis [15, 16], and rheumatoid arthritis [17], are characterized by increased intestinal permeability secondary to noncompetent TJs that allow the passage of antigens from the intestinal flora, challenging the immune system to produce an immune response that can target any organ or tissue in genetically predisposed individuals [18–21].
The conclusions are comprehensive:
Helen mentioned it, but I would like to reiterate that this is nothing new. KDM and others have been working on altered Gut microbiome and bacterial translocation in patients and in research.EDIT: got to the discussion section and here it is in their own words: "An altered microbiome is postulated to lead to increased gut permeability (“leaky gut”) and intestinal inflammation with gastrointestinal symptoms. Increased translocation of lipopolysaccharides (LPS) from gram-negative bacteria leads to autoantibody production, disruption of tight junctions, and both local gastrointestinal and systemic inflammation
I have bacterial translocation with a proven host of nasty gut bugs rampant in my blood stream. I'd quite like to be able to treat that directly.best bet is to look at this as a very complex ecology that is out of balance rather than bugs we need to find and kill
If it's true that LPS and other microbial products are getting into the bloodstream and causing inflammation, that's an avenue for treatment.
But their own results suggest there's no evidence of elevated cytokines.
Mutaflor and Symbioflor 1 are both e-coli probiotics that have been shown to help some people with ME/CFS.It can also be quite beneficial in humans (...apart from when someone horrid doesn't wash their hands after wiping their bum before making you a lovely home made pie).
Seriously E. coli gets a bad wrap ....there are lots of different strains but generally you can happily have it in your gut with no bad effects. Probably best to quote the strain rather than just say E. coli since most E. coli strains are a good thing in your gut.
That would be my assumtion.Unless the cytokine profile is so different from person to person, they can't establish any consistency or patterns.
Aside from we just do not know enough and need more evidence of what is going on, this research might give us a non-invasive biomarker for ME.Which makes me wonder even more - what's the point of this research?
I think some of the research mentions chemicals found in fruit and vegetables, especially apple skins, can help with LPS induced problems. I was going to blog on this some years back then my brain crashed again.If it's true that LPS and other microbial products are getting into the bloodstream and causing inflammation, that's an avenue for treatment.
That is an observation, we need to be careful about interpreting it. Cytokine production might be impaired, or there might be other reasons.But their own results suggest there's no evidence of elevated cytokines.