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Long-Term Use of Antibiotics Associated with Later-Life Colorectal Adenomas
- Thread starter Dolphin
- Start date
Interesting - I was given vast amounts of abx for alleged Lyme disease for 18 months by the Breakspear clinic in 2008-9 (they had no effect on my ME). And in the last 4 years I've had two adenomas removed - one was large with high-grade dysplasia.
Yes I had some bleeding with the first one and that was why I had the colonoscopy. That was the large one. I was told to have another colonoscopy in 3 years and so had that a couple of months ago and they found another smaller adenoma. I hadn't had any symptoms with that one.
And yes I did take probiotics - can't remember which though.
Daffodil
Senior Member
- Messages
- 5,875
oh no. may I ask what kind of bleeding you had? was it on the poop (sorry) or just the toilet paper when you wiped?
Just on the toilet paper - it was very little, and would come and go.
Daffodil
Senior Member
- Messages
- 5,875
oh dear. i have had that for decades. i had a colonoscopy once in my life, over 10 yrs ago. i was always under the impression that the time to worry is when blood is on the poop....but tiny amounts would not be noticed there anyway
i am so glad you posted this @Dolphin and @Jenny
i am so critical of poeple now who ignore their health and i have done it myself by not having colonoscopies ugh
xo
Do see a doctor about this Daffodil. I didn't find the colonoscopies to be painful or even uncomfortable, especially with a sedative. The prep is the worst thing.
This is a concerning study, and it certainly strikes a cord for anyone who has had a suspected or confirmed disease that drew protracted abx therapy. (It may prove popular in the abx stewardship lobby, though.)
Incidentally, I had over 15 polyps removed during my last colonoscopy, and that was before I ever embarked on a lengthy abx therapy for suspected TBDs.. I wonder if it is, in part, the way some of our bodies may react to chronicity rather than the abx, but that seems kind of a stretch unless the condition is cross-elastic across a spectrum of diseases. Regardless, I am certainly taking these findings to heart, and will bring them up with my infectious disease specialist when next I see him.
Incidentally, I had over 15 polyps removed during my last colonoscopy, and that was before I ever embarked on a lengthy abx therapy for suspected TBDs.. I wonder if it is, in part, the way some of our bodies may react to chronicity rather than the abx, but that seems kind of a stretch unless the condition is cross-elastic across a spectrum of diseases. Regardless, I am certainly taking these findings to heart, and will bring them up with my infectious disease specialist when next I see him.
Hip
Senior Member
- Messages
- 17,852
It is a pity this study did not also examine the relative risk of developing colorectal adenoma, the precursor for the majority of colorectal cancers, in patients given long term antibiotics, but then who afterwards and/or during this course of antibiotics, took probiotics in order to repopulate their gut with friendly bacteria.
The probiotics may well have negated the increased risk of developing colorectal adenoma from long term antibiotic use. It's even conceivable that people taking antibiotics + probiotics might result in a lower risk for colorectal adenoma (ie, antibiotics killing off bad bacteria, and the probiotics then replacing them with good bacteria).
This paper examines some of the possible mechanisms by which probiotics (and the prebiotic foods which feed them) may prevent colorectal cancer.
The paper says the possible beneficial anti-colorectal effects of probiotics include:
I have always made of point of taking probiotics for at least week after any antibiotics I take.
On the subject of prebiotics:
This paper mentions that the number of colon polyps appearing in rats feed a high-beef diet was reduced when rye bran was added to the high beef diet, but there was almost no reduction of polyps at all when inulin was added to the high beef diet (inulin is a prebiotic found in fruit and vegetables, and sold as a prebiotic supplement).
Though they point out that there have been a number of contradictory studies on the protective effects of prebiotics on colon cancer.
The probiotics may well have negated the increased risk of developing colorectal adenoma from long term antibiotic use. It's even conceivable that people taking antibiotics + probiotics might result in a lower risk for colorectal adenoma (ie, antibiotics killing off bad bacteria, and the probiotics then replacing them with good bacteria).
This paper examines some of the possible mechanisms by which probiotics (and the prebiotic foods which feed them) may prevent colorectal cancer.
The paper says the possible beneficial anti-colorectal effects of probiotics include:
I have always made of point of taking probiotics for at least week after any antibiotics I take.
On the subject of prebiotics:
This paper mentions that the number of colon polyps appearing in rats feed a high-beef diet was reduced when rye bran was added to the high beef diet, but there was almost no reduction of polyps at all when inulin was added to the high beef diet (inulin is a prebiotic found in fruit and vegetables, and sold as a prebiotic supplement).
Though they point out that there have been a number of contradictory studies on the protective effects of prebiotics on colon cancer.
TigerLilea
Senior Member
- Messages
- 1,147
- Location
- Vancouver, British Columbia
You want to catch adenomas/polyps long before they start bleeding. If you notice changes in your bowel habits for longer than two weeks it should be checked out. Also if your poops become long and skinny that is a sign that there is an obstruction.