Hi all,
I was reading the recent Australian research here about defective calcium channels in ME/CFS patients and then stumbled upon this:
Depletion of intracellular calcium stores activates a calcium current in mast cells
http://www.nature.com/nature/journal/v355/n6358/abs/355353a0.html
This seems to link up with what the Australian study suggests about having to deplete the calcium stores first. I'm no expert and usually just try to piece together info out of desperation because I want to try get better but does this idea of depletion (like the way B cells are depleted using Rituximab) hold the key to flicking the switch forcing a reset in ME/CFS?
Does anyone think it would be possible/worth trying to deplete calcium stores then boost TRPM3 using Pregnenolone or something similar? Or is it waaay too soon to assume that would help ME/CFS sufferers in any way? (I have no idea how you would safely deplete calcium stores because ionomycin looks pretty dangerous but just thought i'd raise the question).
Cheers,
AdamS
I was reading the recent Australian research here about defective calcium channels in ME/CFS patients and then stumbled upon this:
Depletion of intracellular calcium stores activates a calcium current in mast cells
http://www.nature.com/nature/journal/v355/n6358/abs/355353a0.html
This seems to link up with what the Australian study suggests about having to deplete the calcium stores first. I'm no expert and usually just try to piece together info out of desperation because I want to try get better but does this idea of depletion (like the way B cells are depleted using Rituximab) hold the key to flicking the switch forcing a reset in ME/CFS?
Does anyone think it would be possible/worth trying to deplete calcium stores then boost TRPM3 using Pregnenolone or something similar? Or is it waaay too soon to assume that would help ME/CFS sufferers in any way? (I have no idea how you would safely deplete calcium stores because ionomycin looks pretty dangerous but just thought i'd raise the question).
Cheers,
AdamS