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Methylation has been infiltrated by a great deal of quackery, attributing pretty much every symptom imaginable to undermethylation or overmethylation, and sometimes both at the same time. I very much doubt there's any connection with weight gain.Why is Overmethylation associated with weigh gain and difficulty in losing it?
Methylation has been infiltrated by a great deal of quackery, attributing pretty much every symptom imaginable to undermethylation or overmethylation, and sometimes both at the same time. I very much doubt there's any connection with weight gain.
I wonder about this connection too!! Every time I have an overmethylation episode, I gain about a pound. And it doesn't go away no matter how much I exercise or how clean I eat. It is seriously frustrating. I have spent hours and hours researching but no real answers...
I think the main problem is that we don't know enough to make broad sweeping statements like " over methylation causes weight gain". It's too far removed from the end process to attribute definitively attribute cause? It's probably riding on the back of hypothyroidism studies ?
My test of quackery is to find 5-10 separate pieces of research that points in the same direction. If they exist it's worth looking into further, if not then I'm afraid .......To make it substantive I would like to see clinical research with patient studies, but that isn't always available. I dismiss books as being fiction unless there is clear references to research. Phrases like "it is believed that....." Or " many believe " or "it is thought". Generally can be interpreted as " I don't have any research to back this point up"
The fact that you can't find anything substantive gives you the answer I think?
I know how your feel. I slipped into this after a serious bout of stress 10 years ago and haven't been able to lose a pound since.. All thyroid hormones are at optimal levels so I'm stumped. Running 65 km a week and gym have done nothing for my weight. If anything I've got fatter.
I know how your feel. I slipped into this after a serious bout of stress 10 years ago and haven't been able to lose a pound since.. All thyroid hormones are at optimal levels so I'm stumped. Running 65 km a week and gym have done nothing for my weight. If anything I've got fatter.
I think the main problem is that we don't know enough to make broad sweeping statements like " over methylation causes weight gain".
My husband is an overmethylator and has been lean and muscular for most of his life.
He has always been an extremely healthy eater who never eats fast food, fried/junk food, or much in the way of desserts or snacks. He also has been active in sports and weightlifting for most of his life.
I think eating habits and activity levels are far more important than methylation status.
I tried to figure this out a few times but it's impossible to get a clear picture.
On one hand, histone and DNA methylation factually affects the browning of white adipose tissue and expression of brown adipose tissue (http://www.jbc.org/content/early/2015/08/25/jbc.M115.662650 + several others). Even worse, if some PGC-1α promoters get too methylated it could stop thyroid from working (https://www.ncbi.nlm.nih.gov/pubmed/24622795). (PGC-1α is "the master regulator of mitochondrial biogenesis" in wikipedia's opinion).
It looks damning but you can't say much about what dietary methyl groups will do in relation to that if anything. The methylation of some other promoters does the exact opposite, those just stand out the most. In articles they mostly blame palmitic acid for everything (figures).
The closest you get to saying that dietary methyl groups contribute to fat gain is from the liver effects of SAMe:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336596/
If you increased the export of VLDL and it's malformed on top that has potential to affect fat mass (sure this is NAFLD but I bet you're not flaunting your liver health).
In a general way liver methylation cycle is tied to liver lipid handling. I don't know the extent to which it happens in other tissues. Maybe someone has better information, but they're not posting it...
Why is Overmethylation associated with weigh gain and difficulty in losing it? What causes the weight gain and difficulty in losing weight for Overmethylators? Is it linked to low histamine?
Does anyone understand the process enough to explain it?
Thanks