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I too wonder about the GAD1 gene. I'm actually heterozygous for 9 out of 11 SNPs listed from MTHFRSupport.com. Wonder if this could explain some of the anxiety which been arising more and more the last 6 years. I do wonderful on Gaba-agonists (who doesn't?) but thats not a long-term solution as down-regulation would leave you feeling even more anxious.
I definitely can attest to the high Glutamate, low Gaba. Anyone digged deeper into this? Guess it could be very beneficial for people with GAD1 mutations to supplement with something that balances this out. A bit interested in NMDA-antagonists which seems to be good for excessive glutamate signaling. I tend to do pretty good on them too.
No it doesn't. To know if there's any impact, you have to read the research regarding each SNP.Well 9 hetero GAD1 genes have to mean it has some impact.
No it doesn't. To know if there's any impact, you have to read the research regarding each SNP.
No it doesn't. To know if there's any impact, you have to read the research regarding each SNP
The statement was that the SNPs "have to" have an effect. They don't have to do any such thing.It MAY or MAY not, would be a better (polite) answer to that.
Yes, that's why it's necessary to read the research, as I said above.If there is evidence for that, I want to know.
Well, your opinion is "interesting", but science disagree. And I'm afraid I trust the results of decades of methodological investigations by a lot of people a lot more than I trust someone's opinion.In my opinion every single SNP MAY have som kind of inpact on each person, and the combination of his mutations could have an patological inpact if the combination is not a good one.
There's been plenty of genetic research on healthy people.What really makes me sad is that researchers make their statements by researching people that have messed their lifes up with poisening all their life.
Sorry, it doesn't work that way. The research controls for lifestyle factors related to the genes involved.You can not say that this gene gives a person more chanse of a desease, when the real truth is that "with this gene you have got, you cant live like you have done up today".
Do you have a reputable citation which supports that rather unusual claim?But everyone should know that it took X years before feeling sick, and it will take the same X years to be as quick as you where.
And there are a thousand other things which could cause the same symptom. If you truly believe that GAD1 is "killing" you, there are doctors who can confirm that it is indeed the problem.I also have a lot of mutations in GAD1 gene, and 2 of them rarer than 3%. I know this gene is killing me, because all researching i have read fits me perfectly.
"Belief" is not scientific. It is based on faith when there is a lack of evidence. You'd might as well believe that sitting down at the wrong time of day can cause the same symptoms.Yes, I truely believe that if you got the symptoms that researcers have found for those 9 genes, it may well have some inpact on you all together.
As will many other things. It doesn't make sense to fixate on a single cause, especially when there is no research showing those SNPs to have any impact.Low GABA will often manifest with more pain, stiffness, feeling of inner turmoil, anxiety.
Do you mean you are homozygous for 2 SNPs on the GAD1 gene? Which SNPs are they, and is there research indicating that they are problematic? Most SNPs have no impact at all, and simply being homozygous is irrelevant.I am homozygous for 2 of the GAD1 genes and I have suffered with horrendous migraines since I was 20.
Do you mean you are homozygous for 2 SNPs on the GAD1 gene? Which SNPs are they, and is there research indicating that they are problematic? Most SNPs have no impact at all, and simply being homozygous is irrelevant.
The GAD1 gene creates the GAD enzyme. But SNPs (single alleles) on the GAD1 gene control how the enzyme is formed. It's the SNPs which can cause the GAD1 gene to have problems, but only specific SNPs can do that. Most variations of SNPs that people have on GAD1 won't make any difference in the enzyme that is created.Yes I am homozygous for 2 of the GAD1 enzymes so having read the above information I think you will agree it is highly likely that the connection I made is entirely possible.
I'm being tested, after my presumed Type 2 diabetes diagnosis from last week was followed by protracted hyperglycemia, ketonuria, nasty headaches, and diarrhea. I should have the results in a few weeks.Do any of you in this thread test positive for autoantibodies for GAD65?