MarbleWarbler
Seeking knowledge
- Messages
- 7
- Location
- California
Hi all,
First post here, please let me know if this would be better posted elsewhere. I am new to navigating these forums.
I've done a brief search to see if anyone else has posted about this before and have searched google extensively regarding adverse reactions to probiotics but have found little info.
The one bit I have to go on is about histamine intolerance talked about here.
https://www.bulletproofexec.com/why-yogurt-and-probiotics-make-you-fat-and-foggy/
I have found consistently that taking probiotics causes a host of adverse reactions for me. Initially I thought it was some form of SIBO, but I am not 100% sure of this theory. The histamine intolerance idea seems plausible to me.
Every time I take a general probiotic (experimented with strengths ranging from 5 billion CFU to 50 billion CFU and many different brands) I experience a crash in mood and energy, an increase in brain fog, an increase in self-hating/low self-esteem thoughts, an unnaturally high appetite with a strong craving for carbs and sugars as well as moderate to severe bloating at every meal.
All in all I generally feel noticeably worse off physically and have moderate to severe negative effects to my mood and mental functioning.
If I stop the probiotic and take herbal antibacterial such as oregano oil or take antibiotics such as rifaxamin I see a clearance of symptoms within a few days. The carb/sugar cravings go away completely and I have a normal appetite again. Mood symptoms will improve and bloating/gas at meals goes away completely.
I have tried taking the probiotic called "Align" to good effect. It only has one strain, B. Infantis, which is supposed to degrade histamine.
Has anyone else experienced these sort of consistent and predictable adverse reactions to probiotics? If anyone has any research or input that could help me figure out what is going on it would be greatly appreciated. As it stands right now I am confused and frustrated with my body's reaction to probiotics which nearly all research I've read shows should be good for me.
As some extra background about me:
I have tried treating myself for candida overgrowth, SIBO, and tried many different diet changes including FODMAPS. I have also tried following the recommendations of the book "Clean Gut" and "Brain Maker".
I eat generally healthy diet although not perfect. I avoid gluten and dairy and refined/processed sugars as much as possible. I have had temporarily good results from "Clean Gut" but they did not last.
I am a 24 year old male. 6' and 175lbs. I go to the gym 3-5 times per week and do a combination of weight training and cardio. I have struggled with depression and anxiety, specifically OCD throughout my life as well as issues with extreme apathy, emotional flatness, anhedonia, and lack of motivation.
I am attempting to self treat my issues through nutrition, exercise, and natural supplements.
I have done genetic testing with 23andme and am attempting to better understand the methylation cycle.
The results of importance from my methylation profile are as follows:
VDR Taq rs731236 AA +/+
MTHFR C677T rs1801133 AG +/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 AG +/-
From my detox profile notable results are:
CYP1B1 L432V rs1056836 GG +/+
CYP1B1 R48G rs10012 CC +/+
CYP2C19*17 rs12248560 CT +/-
SOD2 A16V rs4880 GG +/+
NAT2 R197Q rs1799930 AG +/-
First post here, please let me know if this would be better posted elsewhere. I am new to navigating these forums.
I've done a brief search to see if anyone else has posted about this before and have searched google extensively regarding adverse reactions to probiotics but have found little info.
The one bit I have to go on is about histamine intolerance talked about here.
https://www.bulletproofexec.com/why-yogurt-and-probiotics-make-you-fat-and-foggy/
I have found consistently that taking probiotics causes a host of adverse reactions for me. Initially I thought it was some form of SIBO, but I am not 100% sure of this theory. The histamine intolerance idea seems plausible to me.
Every time I take a general probiotic (experimented with strengths ranging from 5 billion CFU to 50 billion CFU and many different brands) I experience a crash in mood and energy, an increase in brain fog, an increase in self-hating/low self-esteem thoughts, an unnaturally high appetite with a strong craving for carbs and sugars as well as moderate to severe bloating at every meal.
All in all I generally feel noticeably worse off physically and have moderate to severe negative effects to my mood and mental functioning.
If I stop the probiotic and take herbal antibacterial such as oregano oil or take antibiotics such as rifaxamin I see a clearance of symptoms within a few days. The carb/sugar cravings go away completely and I have a normal appetite again. Mood symptoms will improve and bloating/gas at meals goes away completely.
I have tried taking the probiotic called "Align" to good effect. It only has one strain, B. Infantis, which is supposed to degrade histamine.
Has anyone else experienced these sort of consistent and predictable adverse reactions to probiotics? If anyone has any research or input that could help me figure out what is going on it would be greatly appreciated. As it stands right now I am confused and frustrated with my body's reaction to probiotics which nearly all research I've read shows should be good for me.
As some extra background about me:
I have tried treating myself for candida overgrowth, SIBO, and tried many different diet changes including FODMAPS. I have also tried following the recommendations of the book "Clean Gut" and "Brain Maker".
I eat generally healthy diet although not perfect. I avoid gluten and dairy and refined/processed sugars as much as possible. I have had temporarily good results from "Clean Gut" but they did not last.
I am a 24 year old male. 6' and 175lbs. I go to the gym 3-5 times per week and do a combination of weight training and cardio. I have struggled with depression and anxiety, specifically OCD throughout my life as well as issues with extreme apathy, emotional flatness, anhedonia, and lack of motivation.
I am attempting to self treat my issues through nutrition, exercise, and natural supplements.
I have done genetic testing with 23andme and am attempting to better understand the methylation cycle.
The results of importance from my methylation profile are as follows:
VDR Taq rs731236 AA +/+
MTHFR C677T rs1801133 AG +/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 AG +/-
From my detox profile notable results are:
CYP1B1 L432V rs1056836 GG +/+
CYP1B1 R48G rs10012 CC +/+
CYP2C19*17 rs12248560 CT +/-
SOD2 A16V rs4880 GG +/+
NAT2 R197Q rs1799930 AG +/-