Simon
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Update via email from Marian Emr, Communications Director, NINDS
The NIH has awarded seven administrative [mecfs] supplement grants in response to a Notice of Availability that was issued in April 2016. Awarded supplements will enable NIH-funded projects to expand the collection and analysis of biospecimens from individuals with ME/CFS to aid in biomarker identification and help identify potential therapeutic targets.
Also note
The Trans-NIH ME/CFS Working Group will be hosting a telebriefing on Wednesday, November 2, 2016 from 3:00-4:00pm EDT. The purpose of this call will be to offer updates on NIH’s recent activities related to ME/CFS and provide an opportunity for the community to ask questions. Call-in details will be available shortly.
Unfortunately it's not clear how much was awarded, or exactly what for (descriptions may be for the original study, not just the 'supplemental' bit, but here are the details
" More details about the awarded supplements are available at https://www.nih.gov/mecfs/funding under “Funded Projects.” "
NOVA Southeastern University
The NIH has awarded seven administrative [mecfs] supplement grants in response to a Notice of Availability that was issued in April 2016. Awarded supplements will enable NIH-funded projects to expand the collection and analysis of biospecimens from individuals with ME/CFS to aid in biomarker identification and help identify potential therapeutic targets.
Also note
The Trans-NIH ME/CFS Working Group will be hosting a telebriefing on Wednesday, November 2, 2016 from 3:00-4:00pm EDT. The purpose of this call will be to offer updates on NIH’s recent activities related to ME/CFS and provide an opportunity for the community to ask questions. Call-in details will be available shortly.
Unfortunately it's not clear how much was awarded, or exactly what for (descriptions may be for the original study, not just the 'supplemental' bit, but here are the details
" More details about the awarded supplements are available at https://www.nih.gov/mecfs/funding under “Funded Projects.” "
NOVA Southeastern University
- Lubov Nathanson, gene expression in response to exercise
Recent findings suggest that genetic activity influencing the immune system and inflammatory responses may affect the course of ME/CFS. Dr. Nathanson and her team will collect blood samples from individuals with ME/CFS and healthy individuals before, during, and after an exercise challenge. Dr. Nathanson’s team will use innovative technology to comprehensively assess what is happening in the genes of individuals with ME/CFS. The findings of these genetic analyses may help provide new insight into disease onset and progression as well as help identify potential therapeutic targets.
- Mary A. Fletcher,
Gender differences in responset to exercise
Evidence suggests that ME/CFS may affect women to a greater degree than men, but the reasons for the difference are unknown. To investigate the role of gender in this disease, Dr. Fletcher and her colleagues will collect biological samples from adult males with ME/CFS undergoing an exercise challenge, and compare those results with previously collected data from adult females with ME/CFS. Dr. Fletcher and her group will look for differences in immune cell activation, hormones, cellular markers, and genetic activity to help identify potential therapies and improve our understanding of disease mechanisms.
- Louis Nacul, London School of Hygeine and Tropical Medicine, A longitudinal immunological and virological study for ME CFS biomarker discovery
Studies suggest that one cause of ME/CFS may be abnormal changes in the immune system, thought to be associated with a viral infection. Dr. Nacul and his team will continue to collect additional blood samples, at various timepoints, from individuals with ME/CFS or multiple sclerosis, as well as from healthy individuals. Dr. Nacul will compare immune cell activity, genetic patterns and viral markers among the three groups to identify potential biomarkers of ME/CFS. In addition, the samples will continue to be stored in a biobank for use by researchers around the world.
- Ben Katz/Lenny Jason, A prospective study of CFS following infectious mononucleosis in college students
A number of ME/CFS cases in young adults have been linked to infection with mononucleosis and to further examine this association, Drs. Katz and Jason will conduct a larger prospective study of college students, using data from university-based health services. Drs. Katz and Jason will compare data of individuals who fell ill with mononucleosis and then did or did not develop ME/CFS. This analysis may help identify risk factors that predict which individuals will develop ME/CFS and may also provide clues about the underlying causes of the disease.
- Fabien Campagne, Weill Medical College of Cornell University Immune cell gene expression and predictive models in CFS
Diagnosing ME/CFS can be challenging due to lack of biomarkers, which are genetic or cellular molecules that can be used to identify specific diseases, measure disease progression, and track response to treatment. Drs. Campagne and Hanson will continue to collect blood samples from individuals with ME/CFS as well as healthy individuals and use state-of-the-art technology to look for changes in the activity of genes that are involved in the immune system. These results may help identify novel biomarkers, new pathways related to ME/CFS, as well as potential avenues for therapy.
- Mark Davis, Stanford. Adaptive and innate immunity, memory and repertoire in vaccination and infection
Recent studies have shown that increased levels of activated CD8+ T cells are present in blood samples from individuals with ME/CFS. These cells are part of the immune system and typically become triggered following an infection. Dr. Davis and his group are using newly developed technologies to get a detailed look at the structure and function of T cell receptors in individuals with ME/CFS, which may provide clues about the immune system’s response to disease and may identify possible biomarkers.
- Ian Lipkin, Columbia, Center for Research in Diagnostics and Discovery
Multiple findings over the past several years suggest a viral or post-infective connection to ME/CFS. Dr. Lipkin and his colleagues will develop a cutting-edge library containing protein fragments of all known viruses that infect vertebrates, including mammals. Dr. Lipkin’s team will use the protein library to assess blood samples from individuals with ME/CFS and healthy individuals, to identify potential viruses the individuals with ME/CFS have been exposed to and correlate to symptoms of ME/CFS. The results may help advance detection of novel pathogens involved in ME/CFS.
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