For the first year, I split 8.6 into many little nibbles and had a piece on the go much of the day, high up in the buccal pouch. Then it was a tab per week and now I have to remind myself to take a bit each week...maybe 2 mg. I forget and it doesn't seem to do much. I'd stop but I still have quite a cache.
I was super-sick and when my Dr heard that mB12 had "turned on the lights", he said, "I am going to make you feel even better. We'll set you up with injectable."
I started with 3 per week and when I told him that sublingual was still adding a difference, he increased to daily. The more I took the better I felt and so I increased on my own to 2 injections a day.
mB12 has to be protected from light and kept cool. I doubt getting it on line is going to work out.
@ahmo had previously recommended that I contact you about something, MB12 injections I think, but also possibly about how to back down off Freddd's Protocol slowly if it seemed too much or if one wanted to take a break or reassess doses. As my doses on FP get higher, sometimes I contemplate doing that, but for now I am moving forward, and thinking about switching to injections. The expense for Enzy sublinguals is almost close to the cost of getting injections, and even tho Enzy doesn't have citric acid, it does have fructose, and I'm concerned about the effect on tooth enamel/gums.
At first I was thinking about doing Hydroxy, because of Yasko's recommendations for my SNP's, but I have decided to go with MB12. I had taken both forms by injection several years ago after developing a severe B12 deficiency from a high-dose folic acid protocol that was part of LDA injections for allergies (thankfully we caught it before it got to my spine). That was before we knew about methylfolate. Freddd was helping me on a different forum at that time. Back then I thought the hydroxy injections agreed with me better than the methyl injections (although I could tolerate the methyl sublinguals much better than the hydroxy), but I wasn't taking MF, and I think that's why I had problems. Eventually the obvious B12 deficiency symptoms got much better, so several years ago I stupidly stopped taking the MB12 (both sublinguals and injections). My excuse was that the sublingual brand I was taking started using xylitol which does not agree with me, and the MB injections never made me feel better, usually had fatigue/brain fog. I'm sure that was due to getting the doses wrong and from not taking MF or the rest of FP, which didn't exist yet in it's current form.
More on the injections in a future post, because I'm actually writing you today about Adb12. I have so many things to ask you that I hope you don't mind if I write you again with other topics that I know you could really help me with. This post is turning out to be much longer than I thought, so if you want to get to my main question about Adb12, it's at the end.
Somewhat briefly (if that's possible), my story… I have had ME/CFS, fibromyalgia, multiple chemical sensitivities, gut issues/candida since 1987, a year after getting breast implants. After 2000, I also developed uveitis (a serious autoimmune eye disease that has already caused blindness in one eye and makes being on the computer very difficult/painful and it can cause uveitis flareups) and years later EHS (electromagnetic hypersensitivity). The best results I ever had were in the early 90's from EPD injections (now known as LDA, which has posts on this forum). I was even able to start working again. EPD came from England and the FDA banned it about 20 years ago, so LDA was formulated in the US, but was too strong for me and after several overdoses I got even worse, especially the chemical sensitivities, and EHS started thereafter.
Somewhere in the early to mid-2000's, I also started having occasional migraines and mild seizure-like episodes (not epileptic or grand mal) triggered by flashing lights/sounds, steroids, and extreme stress. A neurologist I saw called it "sensitive brain". I think it had to do with B12 deficiency and/or hormone fluctuations from peri-menopause. Migraines occurred primarily when my estrogen would get low. Everything definitely got worse after peri-menopause. Around that time, my regular doctor thought I may have also had a mild stroke or TIA, because at some point I developed severe aphasia for a while, where I could barely speak in sentences, tho I was able to write much better than I could speak. I think it was related to B12 deficiency, or a combination of everything I was going through at that time. That got a lot better, but I still don't feel like I can communicate as well as I could before then.
Last thing of note, I discovered in 2012 that I had elevated arsenic from eating brown rice. I tried cutting back on the brown rice but it didn't help significantly. I did not know about Cutler, so in 2015 I let my doc give me 8 treatments of EDTA IV chelation over a period of 5 months. He started very low dose, and I seemed to be tolerating it, but as he started increasing the dose, it really started to affect my brain. Finally had to stop it because I just couldn't think clearly anymore at all. It was not like any other brain fog I had ever had. (BTW after a 2014 eye surgery, I started having vertigo-like dizziness similar to what you described having, usually for me from being online, but it's better now! Also mild seborrhea got much worse after that surgery and has not gotten much better yet.) After stopping chelation, I found out about Rich's methylation research online, so I decided to try acetyl glutathione which I saw in one of his articles. I stopped after 3 weeks of being really sick on that, which led me to FP!
I have been faithfully and continuously on FP since 10/2015, and have been slowly but surely getting better! Some things had already greatly improved or had mostly resolved before FP: migraines, seizure-like episodes, fibromyalgia, candida,
are all better, mostly I suspect to my hormones evening out.
Since being on FP my asthma is better than it's ever been in my life; brain fog improved and getting better; burning mouth/tongue and EHS showing some improvement; slight improvement with skin stuff.
Gut issues were improving off and on, but are flared right now, but could be due to my refrigerator not keeping cold enough since the summer heat. Chemical sensitivities had improved until a big flareup this week, probably caused from buying a new chest freezer as an intermediary step to getting a new refrigerator. Chemicals/smells from my last new refrigerator 7 years ago made me very ill for quite a while.
I am currently taking total per day: Solgar MF 3,800mcg, Enzy MB12 9,000mcg, AdB12 2,000mcg (1/4 of Source Naturals tablet, the only brand I can tolerate), Dr's Best LCF 1,000mg. I take the MF and MB 3x/day and LCF 2x/day empty stomach in divided doses. I take the AdB12 1x/day with my pm MB.
I've also been taking the other primary recommended supplements (except only recently trying to add in zinc), including at least 900mgs potassium daily. I haven't been able to increase FP as fast as many others, but was inc at least 3x/month and might to step that up after current chemical senditivity flareup, as I seem to be tolerating increases better.
Finally on to my main question about AdB12, (AD for short): It took me 8 months to titrate up from a crumb per day to 1/4 Source Naturals tablet, so for now I think I need to stay with taking it daily, since I can't take a large enough dose to take it once a week. I also think I get a better result from taking it every day, like you did in the beginning. When I first started taking it, I would get a tightness in my chest, that wasn't asthma but I felt like I couldn't breathe as well, and my heart would race. It was like what I would imagine taking too much speed would be like. (I had a similar reaction to LCF, which also took me 8 months to titrate up to 1 entire capsule 2x/day. Now I don't think I can live without LCF, because my energy drops without it, which worries me.)
Last Sunday I tried to increase AD to 3/4 of a tablet. I also decreased my pm MB that I take with it by 1/4 tablet,
due to posts by Freddd about how you shouldn't take AD and MB together. He says they can offset each other where one or both might not work as well, due to biochemical reactions that you probably understand better than I do. I was formulating a plan to slowly decrease my pm MB as I increased the AD. Also
@ahmo told me that she takes her AD dose away from her MB dose like Freddd does, but they both do it once a week, whereas I need to stay at once a day for now.
After reading your posts above, and finding out that you took AD and MB together with good results the entire time you were doing AD daily, I am rethinking my plan. The AD increase I did from Sunday to Thursday seemed to be having a positive effect on my energy, and possibly my brain too. However on Friday I decreased back to my regular dose because of the big chemical sensitivity flareup. It's probably due to eating food from the new chest freezer, but because I had also changed my supplements on Sunday,
@caledonia recommended putting everything back to where it was for now.
I just wanted to get your feedback on taking AD and MB together daily, because that seems to be what is working for me right now. I would probably just continue to take the AD with my pm MB dose, steadily increasing both, if you don't think that would cause a significant reduction in how either one of them is working (after my current allergy flareup subsides). Do you think I should also experiment with taking smaller quantities of AD throughout the day like you did instead of just once a day? That seems to give more opportunities to interfere with MB though. @ahmo and
@caledonia would appreciate your thoughts on this too!
Eventually I would very much appreciate getting more details on translating MB sublinguals to injections from you. I already have a prescription from my doc for MB 10mg per ml, on file with a compounding pharmacy that will ship it on ice. Later I would also really be grateful to find out details on how you were able to increase everything to the point where you were taking AD once a week, and then how you decreased your doses to where they are now after you got much better. It's a lot to ask all at once, so I don't mind spreading it out, especially since my eyes need a big rest and hopefully I will not get a bad report from the eye doc tomorrow! Thank you so much for any help you can give!