Sorry if this post is all over the place. I've actually been taking for.. like a good year + methylfolate. I didn't notice a significant difference though and when I would add things like b12 I had weird reactions. Anyway so recently I started taking significant very large doses of b12 2500mcg, methylb9 10mg, b6 200mg as well as b complex and find that I am feeling better than I have in a long time. But still have some issues with I think dopamine, also definitely still having food sensitivities and just feeling generally itchy.
I'm thinking maybe adding in betaine TMG would help? And taking out high sulfur foods. What else should I be doing?
So first I'm heterozygous for A1298C which I think most people already know what that means..
Also I am homozygous cbs
In these patients, it's common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine. This leads to high levels of taurine and ammonia. The CBS upregulation has been clinically observed to result in sulfur intolerance in some patients. Other mutations, such as MTHFR A1298C, Chronic bacterial infections, and aluminum can also lead to low BH4 levels. Lack of BH4 can lead to mast cell degranulation and possibly mast cell activation disorder (MCAD).
Homozygus MTR A2756G helps recycle B12. The combination of MTR and MTRR mutations can deplete methyl B12.is not very common (<1% of CEU population). Some studies have demonstrated that people with a combination of MTHFR C677T and MTR A2756G have persistently high homocysteine levels unless they are treated with both B12 and folate.
homozygous
MAO-A R297R
MAO-A (Monoamine oxidase A) is a critical enzyme involved in breaking down important neurotransmitters such as serotonin, norepinephrine, and dopamine. Males only have one allele since the gene is inherited through from their mother since it is located on the X chromosome. (kinda confused about this one because it seemed to not be as important unless combined with a comt mutation which I have none.
THen I'm also:
Heterozygus for
I'm thinking maybe adding in betaine TMG would help? And taking out high sulfur foods. What else should I be doing?
So first I'm heterozygous for A1298C which I think most people already know what that means..
Also I am homozygous cbs
In these patients, it's common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine. This leads to high levels of taurine and ammonia. The CBS upregulation has been clinically observed to result in sulfur intolerance in some patients. Other mutations, such as MTHFR A1298C, Chronic bacterial infections, and aluminum can also lead to low BH4 levels. Lack of BH4 can lead to mast cell degranulation and possibly mast cell activation disorder (MCAD).
Homozygus MTR A2756G helps recycle B12. The combination of MTR and MTRR mutations can deplete methyl B12.is not very common (<1% of CEU population). Some studies have demonstrated that people with a combination of MTHFR C677T and MTR A2756G have persistently high homocysteine levels unless they are treated with both B12 and folate.
homozygous
MAO-A R297R
MAO-A (Monoamine oxidase A) is a critical enzyme involved in breaking down important neurotransmitters such as serotonin, norepinephrine, and dopamine. Males only have one allele since the gene is inherited through from their mother since it is located on the X chromosome. (kinda confused about this one because it seemed to not be as important unless combined with a comt mutation which I have none.
THen I'm also:
Heterozygus for
- VDR Bsm VDR seem to affect dopamine and vitamin d levels
- VDR Taq
- BHMT-02 seems to affect conversion of homocystein to methionine
- BHMT-08