I am wondering about the connection between homocysteine and methylation. I have quite a hx of cancer in myself and family. I have had 23andme done and am +/- for C677T.
I had homocysteine checked 6 months ago and it was 9.7....higher than my doctor would like. He would like me to take MB12 and folate but I am reluctant to do so as I am COMT++ and sensitive to methyl donors. I'd rather focus on getting more folate in my diet.
I have had the OAT test done and methymalonic acid is low - I believe this indicates that B12 is good. There was nothing on the OAT test (that I could see) that indicated that folate was low.
I should probably have my homocysteine tested again to see if it has come down.
Another reason for asking about homocysteine as a possible marker for methylation is for my family members. I wonder if they should have homocysteine checked as an indicator of their methylation. Some of them do not have the $ to do a lot of testing.
Thanks for any insights you can give!
++: COMT V158M, COMT H62H, VDR Taq, BHMT-02, BHMT-08, +-: MTHFR C677T +/-, MAO-A R297R, ACAT1-02, MTRR A66G, MTRR A664A, CBS A360A,
I had homocysteine checked 6 months ago and it was 9.7....higher than my doctor would like. He would like me to take MB12 and folate but I am reluctant to do so as I am COMT++ and sensitive to methyl donors. I'd rather focus on getting more folate in my diet.
I have had the OAT test done and methymalonic acid is low - I believe this indicates that B12 is good. There was nothing on the OAT test (that I could see) that indicated that folate was low.
I should probably have my homocysteine tested again to see if it has come down.
Another reason for asking about homocysteine as a possible marker for methylation is for my family members. I wonder if they should have homocysteine checked as an indicator of their methylation. Some of them do not have the $ to do a lot of testing.
Thanks for any insights you can give!
++: COMT V158M, COMT H62H, VDR Taq, BHMT-02, BHMT-08, +-: MTHFR C677T +/-, MAO-A R297R, ACAT1-02, MTRR A66G, MTRR A664A, CBS A360A,