Trying to figure something out - as I am becoming more allergic/reactive.
Wondering if it has something to do with IGE and Gamma.
Note my total IGE levels (Ref. range 0-100)
Oct 2009 - 132 - No Dx - Never had infused Gamma
July 2010 - 187 - Testing - Still no Gamma - IGG 570's
Dec 2011 - 383 - Four months past first/only 30g IVIG (started IVIG again after this test)
April 2013 - 1454 - Had started SubQ Gamma weeks prior (IGG 1100)
March 2016 - 327 - Still on SubQ Gamma but had taken breaks - on much lower dose - (IGG 660)
There is a small amount of IGE in Gamma - with very short half-life in blood of about 2-3 days.
(My allergist/immuno said testing me for allergies would be difficult because of the IGE in Gamma).
I note - coincidence or other factors - that my IGE was lowest before ever starting Gamma and highest when my "trough' level was high (for me) on SubQ Gamma of 9 grams/week.
Can the body make IGE antibodies against the IGG and/or IGA in Gamma?
Wondering then if the 383 of Dec 2011 meant that my body was "still" making IGE antibodies from the infusion four months prior. It can take months before the antibodies completely clear the body?
Perhaps could explain that my 3-4 week breaks from Gamma doesn't change how I feel?
(bad - and very allergic/reactive/chemical sensitive).
IGE made against a "foreign invader" ie the antibodies/whatever else is in IVIG?
This probably doesn't make much sense - sorry - am so tired.
Any thoughts/experiences with this? Thanks. Susan
Wondering if it has something to do with IGE and Gamma.
Note my total IGE levels (Ref. range 0-100)
Oct 2009 - 132 - No Dx - Never had infused Gamma
July 2010 - 187 - Testing - Still no Gamma - IGG 570's
Dec 2011 - 383 - Four months past first/only 30g IVIG (started IVIG again after this test)
April 2013 - 1454 - Had started SubQ Gamma weeks prior (IGG 1100)
March 2016 - 327 - Still on SubQ Gamma but had taken breaks - on much lower dose - (IGG 660)
There is a small amount of IGE in Gamma - with very short half-life in blood of about 2-3 days.
(My allergist/immuno said testing me for allergies would be difficult because of the IGE in Gamma).
I note - coincidence or other factors - that my IGE was lowest before ever starting Gamma and highest when my "trough' level was high (for me) on SubQ Gamma of 9 grams/week.
Can the body make IGE antibodies against the IGG and/or IGA in Gamma?
Wondering then if the 383 of Dec 2011 meant that my body was "still" making IGE antibodies from the infusion four months prior. It can take months before the antibodies completely clear the body?
Perhaps could explain that my 3-4 week breaks from Gamma doesn't change how I feel?
(bad - and very allergic/reactive/chemical sensitive).
IGE made against a "foreign invader" ie the antibodies/whatever else is in IVIG?
This probably doesn't make much sense - sorry - am so tired.
Any thoughts/experiences with this? Thanks. Susan