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TRIAL BY ERROR: The Troubling Case of the PACE Chronic Fatigue Syndrome Study

Ellkaye

Senior Member
Messages
163
The 5 million pound PACE fiddles of the same band that continue to play on and on. The music they've been producing brainwashed two generations of medics globally. Frightening influence. Chilling effect. Truly horrific in its reach and influence. It was too easy for them.
I don't know what disease they've been treating but it is not the ME as defined by Melvin Ramsay. An expert panel needs to do the right thing now. And the Lancet have to ask searching questions, listen to testimonies,and ultimately withdraw this paper. Everybody has to come together and say a very big No to this paper.

Almost as bad as that Dr Oz show where they kept going on about a woman's disease..Unbelievable that the MD's and researchers on that show let that go. Man up all you sick men ! You don't want this woman's disease do you !! How can anything those researchers publish have an iota of credibility after that !

Games. Games, and games.Pulling out every trick in the book.

Just reporting the facts.

One big poker game. Bluffers all around the table. They just kept winning by bluffs and tv shows. A true dishonour. Shameful. Imagine you're a true ME patient sitting round the poker table with these guys, the cbt/get ers on your left and pre/post 3year-cytokines/chemokines ers on your right just as bad. What do you do? Just what do you do?

You call their bluff until they fold and only then do you look at them straight in the eyes.

Remember Charles Van Doren : "I lied to the American people.I lied about what I knew,and then I lied about what I did not know.''
 
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Tom Kindlon

Senior Member
Messages
1,734

ballard

Senior Member
Messages
152
Dragon.png


A huge thank you to David Tuller and James Coyne for their magnificent efforts to have the very damaging
PACE trial retracted from The Lancet. For all the amazing people who are contributing to this effort, including
Tom Kindlin and Vincent Racaniello, my best regards and gratitude.

Thanks also to SOC (aka Annie Gsample) for suggesting the dragon idea for a cartoon.

More CFS graphics at cfsgraphics.com
 

Tom Kindlon

Senior Member
Messages
1,734
View attachment 13786

A huge thank you to David Tuller and James Coyne for their magnificent efforts to have the very damaging
PACE trial retracted from The Lancet. For all the amazing people who are contributing to this effort, including
Tom Kindlin and Vincent Racaniello, my best regards and gratitude.

Thanks also to SOC (aka Annie Gsample) for suggesting the dragon idea for a cartoon.

More CFS graphics at cfsgraphics.com
Thanks. By the way, it's spelled "Kindlon" not "Kindlin".

FYI, I've tweeted your image and James C Coyne liked it:

See also:
 

Yogi

Senior Member
Messages
1,132
Other interesting twitter accounts to keep an eye on.

Stony silence from Lancet apart from Pam "results of the PACE trial paved the way for this IOM report" *Das 6 hours ago recruiting a new media officer to deal with the aftermath of this! I think they need more than a media officer and maybe advertise for jobs for some peer reviewers!! Comical! To think this was once a world renowned and very respected medical journal.


What a farce!!

It would be hilarious if people who were the victims of this bad joke of the PACE trial were not suffering from a severe neurological disease and being bed-ridden and dying from the disease!!!


*http://forums.phoenixrising.me/inde...-systemic-exertion-intolerance-disease.35729/

Drum roll........Ladies and Gentleman !

Here is the media relations officer that Pam Das and the Lancet were recruiting after David Tuller's expose.

Miss Seil Collins
https://uk.linkedin.com/in/seil-collins-74413a47

1. She has done a course at King's College London in Crisis Management
2. She was Press Officer, Institute of Psychiatry, Psychology & Neuroscience
King's College London

It is all very incestuous with this lot. No conflict of interest here. I can imagine Wessely would have given her a good reference.

This looks like Lancet are going to dig their heels in with PACE.
 
Messages
2,087
Drum roll........Ladies and Gentleman !

Here is the media relations officer that Pam Das and the Lancet were recruiting after David Tuller's expose.

Miss Seil Collins
https://uk.linkedin.com/in/seil-collins-74413a47

1. She has done a course at King's College London in Crisis Management
2. She was Press Officer, Institute of Psychiatry, Psychology & Neuroscience
King's College London

It is all very incestuous with this lot. No conflict of interest here. I can imagine Wessely would have given her a good reference.

This looks like Lancet are going to dig their heels in with PACE.

How about a 'good luck in your new job' card ?
:D
 
Messages
13,774
I'd forgotten how bad the PACE recovery press release was.

Rehabilitation therapies can lead to recovery from chronic fatigue syndrome
Posted on 31/01/2013
CachedImage.axd

Research led by King's College London in collaboration with Queen Mary, University of London, the University of Oxford and the Medical Research Council (MRC) has shown that recovery from chronic fatigue syndrome (CFS) is possible for some patients, and has identified two treatments most likely to lead to recovery.

The latest results from the PACE trial show that cognitive behaviour therapy (CBT) and graded exercise therapy (GET), as supplements to specialist medical care, increase the likelihood of recovery from CFS three-fold compared to other treatments studied. The trial is published today in Psychological Medicine.

CFS is a long-term and debilitating condition that affects around 250,000 people in the UK. Symptoms include profound physical and mental fatigue (characteristically made worse by exertion), muscle and joint pain, disturbed sleep and both concentration and memory problems. The researchers studied 640 participants with CFS who were randomised into one of four treatment groups:

  • Specialist medical care (SMC) alone;
  • SMC plus adaptive pacing therapy (APT);
  • SMC plus cognitive behavioural therapy (CBT);
  • SMC plus graded exercise therapy (GET)
Evidence for recovery was assessed one year after participants were randomly allocated to treatments.

Previous published results showed that both CBT and GET led to greater reductions in symptoms and disability than either APT or SMC. In this analysis the researchers have gone a step further and examined how many patients had recovered from their illness after these treatments. Patients were classed as recovered if they no longer met several criteria for ill health which were initially used to define eligibility for the trial. These included not suffering from significant fatigue or physical disability, and no longer meeting diagnostic criteria for CFS. Patients also had to rate themselves as being “much” or “very much better” in their overall health.

The findings showed that those who received CBT or GET, in addition to SMC, were three times more likely to meet the criteria for recovery than those receiving SMC alone or in combination with APT. Overall 22 per cent of those who received either CBT or GET, in addition to SMC, met the criteria for recovery, compared to eight per cent after APT in addition to SMC, and seven per cent after SMC alone. There were similar patterns of recovery however CFS was defined, including those who were diagnosed as having myalgic encephalomyelitis (ME), thought by some to be the same as CFS and by others as being different.

Professor Trudie Chalder from the Department of Psychological Medicine at King’s College London’s Institute of Psychiatry, said: “The fact that people can recover from chronic fatigue syndrome is excellent news. Healthcare professionals can now be more confident in sharing this possibility with patients, many of whom are understandably concerned about their future.”

Peter White, Professor of Psychological Medicine at Barts and the London School of Medicine and Dentistry, part of Queen Mary, was the lead co-principal investigator of the PACE trial and co-author of the latest paper.

Professor White said: “This is good news and shows that recovery from this debilitating condition is possible for some patients. We now need to go further to understand why only a relatively small proportion of patients recover, which shows how much this condition varies between individuals; one treatment is unlikely to work for everyone.

“Some people may question the use of the term ‘recovery’, and how to define when a patient is ‘recovered’ was a key issue we faced. We focussed on recovery from the current episode of the illness and used several measures of both symptoms and disability to give us the most complete picture possible. Further analysis is needed to see if recovery is sustained in the long-term.”

Professor Michael Sharpe, University of Oxford co-principal investigator of the PACE trial and co-author of the latest paper, said: “The rehabilitative treatments of CBT and GET for CFS have been controversial. This analysis of the PACE trial data shows that not only do they achieve improvements in the majority, but that they can also lead to recovery in a substantial minority.”

Paper reference: White, P.D. et al 'Recovery from Chronic Fatigue Syndrome after treatments given in the PACE trial' Psychological Medicine doi:10.1017/S0033291713000020

For further information, please contact Seil Collins, Press Officer, King's College London, Institute of Psychiatry. Email: seil.collins@kcl.ac.uk or tel: (+44) 0207 848 5377



About the PACE trial:

The PACE trial was funded by the Medical Research Council, Department of Health, Chief Scientist Office, Scotland, and Department for Work and Pensions.

PACE is the largest ever randomised controlled trial of treatments for CFS/ME, led by researchers at Queen Mary, University of London, the University of Oxford and King’s College London. It began in 2005 and compared four of the main treatments currently available for CFS/ME.

All 640 trial participants received specialist medical care, which included general advice about managing the illness and were prescribed medicines for symptoms such as insomnia and pain.

Patients were randomly divided into four groups and three of the groups were also given one of the following therapies over six months:

  • Cognitive behavioural therapy (CBT) – An appropriately trained clinical psychologist or nurse helps the patient to understand how their symptoms can be affected by the way that they think about and cope with them, and encourages them to try increasing their activity.
  • Graded exercise therapy (GET) – An appropriately trained physiotherapist helps the patient to try a gradually increasing tailored exercise programme which takes into account the individual patient’s symptoms, fitness, and current level of activity.
  • Adaptive pacing therapy (APT) – An appropriately trained occupational therapist helps the patient to match their activity level to the amount of energy they have, aiming to help the patient adapt to the illness rather than assuming they can gradually do more.
CBT and GET are used widely in the health service to treat a range of conditions including rheumatoid arthritis, heart disease, diabetes, depression and chronic pain.

Previous findings from the PACE trial found that CBT and GET in addition to specialist medical care (SMC) were more effective treatments, and better value, than adaptive pacing therapy (APT) with SMC, or SMC alone.

http://www.kcl.ac.uk/ioppn/news/records/2013/January/recovery-from-chronic-fatigue-syndrome-.aspx