I'd like to get back on methylation so i've done some basic testing of B12 and folic acid in serum and RBC.
As suspected folic acid in RBC is deficient and lowish in serum. I've not really been supplementing with methylfolate except on the B12 injection days because it makes me feel sick, no matter how low the dosage is.
B12 is higher than the max. measurable level of 2000. I've been trying to get my folate needs from vegetables but clearly that has not been sufficient, the fact that i suffer from inflammatory bowel disease and malabsorption doesn't help either.
What i'd like to know is
What blocks the transport from serum to RBC? Am i lacking cofactors?
Does supplementing with hydroxyB12 deplete the folic acid even further?
I know these are basic questions but i currently don't have the time or motivation to read up on methylation, i'm hoping some of you with more knowledge on methylation would like to chime in.
Results
Folic acid in RBC: 168 (reference range = 221 - 1113)
Folic acid in serum: 6.76 (reference range = 5 - 24)
B12 in serum: >2000 (reference range = 190 - 771)
+/-
MTHFR C677T
MTHFR A1298C
MTRR A66G
MTRR A664A
BHMT-02 , 04 and 08
VDR Bsm + taq
Supplements used related to methylation for the past 2 years:
Hydroxycobalamin I.M. 10000mcg 2 X weekly, but lately more like once every 2 weeks.
Methylfolate solgar, 100mcg - 200mcg 2 X weekly together with the B12 injection
As suspected folic acid in RBC is deficient and lowish in serum. I've not really been supplementing with methylfolate except on the B12 injection days because it makes me feel sick, no matter how low the dosage is.
B12 is higher than the max. measurable level of 2000. I've been trying to get my folate needs from vegetables but clearly that has not been sufficient, the fact that i suffer from inflammatory bowel disease and malabsorption doesn't help either.
What i'd like to know is
What blocks the transport from serum to RBC? Am i lacking cofactors?
Does supplementing with hydroxyB12 deplete the folic acid even further?
I know these are basic questions but i currently don't have the time or motivation to read up on methylation, i'm hoping some of you with more knowledge on methylation would like to chime in.
Results
Folic acid in RBC: 168 (reference range = 221 - 1113)
Folic acid in serum: 6.76 (reference range = 5 - 24)
B12 in serum: >2000 (reference range = 190 - 771)
+/-
MTHFR C677T
MTHFR A1298C
MTRR A66G
MTRR A664A
BHMT-02 , 04 and 08
VDR Bsm + taq
Supplements used related to methylation for the past 2 years:
Hydroxycobalamin I.M. 10000mcg 2 X weekly, but lately more like once every 2 weeks.
Methylfolate solgar, 100mcg - 200mcg 2 X weekly together with the B12 injection