folinic acid vs methylfolate; how do they affect you?

[Kimsie]

For those who have taken both, do any of you have anxiety type overmethylation symptoms with both? Or only with methylfolate and not folinic acid?

Thanks,
Kim

 

[Gondwanaland]

Methyfolate was a nightmare - I was already unwell from MB12, then Mfolate pushed me into acidosis and to a extremely low serotonin state. I assume the anxiety feeling was due to hypoglycemia.

Folinic wasn't a problem at all.

 

[ahmo]

I experienced nothing notable w/ folinic, having tried it several times. I only occasionally got overmethylation sensations when increasing Mfolate, which were easily remedied by taking a MB12.

 

[Kimsie]

Methyfolate was a nightmare - I was already unwell from MB12, then Mfolate pushed me into acidosis and to a extremely low serotonin state. I assume the anxiety feeling was due to hypoglycemia.

Folinic wasn't a problem at all.

Did you feel the effects the same day or did it take a while to build up?

 

[Gondwanaland]

Did you feel the effects the same day or did it take a while to build up?

I think I took methylfolate no more than 4x and then the acidosis symptoms became unberable. I was taking 400mcg and then the last time I took it twice by mistake (800mcg).

 

[Kimsie]

I think I took methylfolate no more than 4x and then the acidosis symptoms became unberable. I was taking 400mcg and then the last time I took it twice by mistake (800mcg).

So you noticed some symptoms the first time you took it?

 

[Gondwanaland]

So you noticed some symptoms the first time you took it?

Yes, I did.

 

[dannybex]

Same as the others. Folinic helps me sleep and helps with noise hypersensitivity. I'm tolerating methylfolate better than in the past (I think), but when I first tried it 3 years ago, it was HELL.

 

[Gondwanaland]

BTW my husband took Mfolate 1x something like twenty or thirty micrograms and his serotonin plummeted.

 

[Aerose91]

I see no differences, positive or negative with either mfolate or folinic

 

[Oberon]

BTW my husband took Mfolate 1x something like twenty or thirty micrograms and his serotonin plummeted.

I am in no way knowledgable in biochemistry but wouldn't methylfolate increase Serotonin? I thought that's why it's successful with treatment resistant depression? What defines a low Serotonin state?

 

[Gondwanaland]

I am in no way knowledgable in biochemistry but wouldn't methylfolate increase Serotonin? I thought that's why it's successful with treatment resistant depression?

Me neither, but I read explanations from knowleadgeable folks here saying that 1) too much serotonin will inhibit serotonin production and this inhibition has a lot of momentum and lasts for several weeks 2) Mfolate activity in the brain is opposed to a SSRI, i.e., it increases serotonin reuptake and then you are left with none by the mechanism (1).

What defines a low Serotonin state?

Extreme sadness in my and my husband's experience.

I also ask myself how Mfolate acts when successfully used to treat depression.