Kathevans
Senior Member
- Messages
- 689
- Location
- Boston, Massachusetts
Hey all,
I'm inching along, keeping an Excell chart of dosages and symptoms. I felt somewhat stabilized lately in my introductory methylation approach, which is to say two of the Deadlock Quartet (along with a host of basics) 4,000mcg Enzymatic's Sublingual MeB12 and 1,000mcg Solgar's Metafolin. My sleep was still crap, but I notice that on the days I pushed upward, I'd often get a more restful night. I seem to have fewer folate insufficiency symptoms with this ratio of 4:1 or even 5:1, and this makes sense given my snps.
Because my very first and still worst symptom (besides the sleep) is the pain where the muscles and tendons come together I've always assumed that Adonosyl B-12 would be important for me. And true to form, early experiments with it showed me to be very sensitive. I tried a half of the Source Naturals Dibencozide, then a quarter--each time only one day a week, and each time to fluttering anxiety, followed by challenging nights.
It occurred to me that I'd only get used to the doses if I took it daily, so a few days ago I settled on 1/8 and had only transient anxiety from the pill itself. I decided to take the AdoB12 in the morning and moved my MeB12 and Folate to the afternoon. Is this how those of you who take it daily do it? Or altogether in the mouth in the morning and another dose of MeB12 and folate in the afternoon?
The first day I went for a walk and felt as if I wasn't exhausted, felt as if I could take a deep breath comfortably and fill my lungs with air. That night I had one block of 4 hours of sleep almost unheard of! and a total of 6 hours. The second night I slept almost equally well. Those black-out blocks of sleep were something of a miracle to me.
But last night was a disaster from the start. I took my 1/4 melatonin and within 20 minutes, instead of feeling tired and drifting asleep, I began to feel anxious. There were occasional rapid heartbeats, but nothing dramatic (I am on a very low dose beta blocker, so that might mask stuff). But knowing this was a symptom of something, I got up and took my 300mg of Potassium, and knowing it could also be over-methylation, or high need for folate and I just didn't know what else, I popped 100mg of niacin and over the course of the next hour wound down enough to go to sleep. Only about 2 hours, then another 2 and that was it.
So I'm dragging today and have taken a lot of time to review my Excell chart. I thought I was getting pretty good at recognizing symptoms, but THIS IS WHAT I MISSED:
- from the first day that I took the Ado B12, I had looser than normal stool followed by irritable bowel before bed.
- my prime areas of pain and injury, my right shoulder and left hip were incredibly sore when I moved or to the touch.
- from the first day I took the AdoB12, my nose was running and I was sneezing during the day; at night I was stuffed up (this is always going on to some extent, but it was worse)
- by day 3 of the Ado B12 I was exhausted after the initial hour or two bump--of the sort not improved by potassium
- my trapezius muscles were much tighter and sore and
- when I climbed into the shower last night, I was weepy, weepy, weepy.
Am I right in seeing this as a Folate insufficiency? Those of you who have ramped up, do you find that Ado B12 increases the need for folate? Perhaps similar to B2?
Should I drop the Ado B12 and continue to increase MeB12 and Folate to higher levels before adding the next member of the Quartet? Or should I continue to take both daily for a while--or forever--and begin to titrate my folate to sufficiency?
Thanks for any thoughts on this member of the DQ and how to titrate up with it. It's been just four months that I've been ramping up on the first two and I can see progress. But the road is still bumpy. I want to be brave and not cower!
O' where is my inner warrior?
K
I'm inching along, keeping an Excell chart of dosages and symptoms. I felt somewhat stabilized lately in my introductory methylation approach, which is to say two of the Deadlock Quartet (along with a host of basics) 4,000mcg Enzymatic's Sublingual MeB12 and 1,000mcg Solgar's Metafolin. My sleep was still crap, but I notice that on the days I pushed upward, I'd often get a more restful night. I seem to have fewer folate insufficiency symptoms with this ratio of 4:1 or even 5:1, and this makes sense given my snps.
Because my very first and still worst symptom (besides the sleep) is the pain where the muscles and tendons come together I've always assumed that Adonosyl B-12 would be important for me. And true to form, early experiments with it showed me to be very sensitive. I tried a half of the Source Naturals Dibencozide, then a quarter--each time only one day a week, and each time to fluttering anxiety, followed by challenging nights.
It occurred to me that I'd only get used to the doses if I took it daily, so a few days ago I settled on 1/8 and had only transient anxiety from the pill itself. I decided to take the AdoB12 in the morning and moved my MeB12 and Folate to the afternoon. Is this how those of you who take it daily do it? Or altogether in the mouth in the morning and another dose of MeB12 and folate in the afternoon?
The first day I went for a walk and felt as if I wasn't exhausted, felt as if I could take a deep breath comfortably and fill my lungs with air. That night I had one block of 4 hours of sleep almost unheard of! and a total of 6 hours. The second night I slept almost equally well. Those black-out blocks of sleep were something of a miracle to me.
But last night was a disaster from the start. I took my 1/4 melatonin and within 20 minutes, instead of feeling tired and drifting asleep, I began to feel anxious. There were occasional rapid heartbeats, but nothing dramatic (I am on a very low dose beta blocker, so that might mask stuff). But knowing this was a symptom of something, I got up and took my 300mg of Potassium, and knowing it could also be over-methylation, or high need for folate and I just didn't know what else, I popped 100mg of niacin and over the course of the next hour wound down enough to go to sleep. Only about 2 hours, then another 2 and that was it.
So I'm dragging today and have taken a lot of time to review my Excell chart. I thought I was getting pretty good at recognizing symptoms, but THIS IS WHAT I MISSED:
- from the first day that I took the Ado B12, I had looser than normal stool followed by irritable bowel before bed.
- my prime areas of pain and injury, my right shoulder and left hip were incredibly sore when I moved or to the touch.
- from the first day I took the AdoB12, my nose was running and I was sneezing during the day; at night I was stuffed up (this is always going on to some extent, but it was worse)
- by day 3 of the Ado B12 I was exhausted after the initial hour or two bump--of the sort not improved by potassium
- my trapezius muscles were much tighter and sore and
- when I climbed into the shower last night, I was weepy, weepy, weepy.
Am I right in seeing this as a Folate insufficiency? Those of you who have ramped up, do you find that Ado B12 increases the need for folate? Perhaps similar to B2?
Should I drop the Ado B12 and continue to increase MeB12 and Folate to higher levels before adding the next member of the Quartet? Or should I continue to take both daily for a while--or forever--and begin to titrate my folate to sufficiency?
Thanks for any thoughts on this member of the DQ and how to titrate up with it. It's been just four months that I've been ramping up on the first two and I can see progress. But the road is still bumpy. I want to be brave and not cower!
O' where is my inner warrior?
K