23andMe results, loss libido and emotions, ssri

[PeterSv]

Hi,
I suffer from emotional blunting and sexual dysfunction after I used SSRI for 3 months 1,5 years ago. I am low on energy and not motivated in life as I used to be. Today I got my 23andMe results back and I would really appreciate if anyone could comment or suggest me to supplement with anything. I am thinking it would be something with my genetics that made me respond so bad to SSRI and not recover.

Methylation Profile (geneticgenie)
COMT V158M rs4680 GG -/-
COMT H62H rs4633 CC -/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO A R297R rs6323 T +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 GG -/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR K350A rs162036 AA -/-
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CC -/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 AG +/-

Heterozygous
VDR Bsm
VDR Taq
MTHFR A1298C
MTR A2756G
BHMT-08
CBS A360A

Homozygous
MAO A R297R
MTRR A66G

 

[Sherpa]

see the link in my signature for how I treated MTRR A66G and MAO A R297R

 

[deleder2k]

What about your HPA axis? Testosterone? Free testosterone? LH? FSH?

 

[Hip]

I developed emotional blunting (blunted affect) from a virus I caught.

 

[PeterSv]

@deleder2k Blood work this summer showed for example:
S-Testosteron 22nmol/L (range 8,6-29)
S-T3 (free) 5,1pmol/L (3,5-5,4)

S-Follitropin(FSH) 1,3E/L (1,0-12,5)
S-Lutropin (LH) 2,7E/L (1,2-9,6)

Thyriod (levels were increased 1 year after SSRI compared to 1 year before SSRI)
S-TSH, tyrotropin 2,5mE/L (1,5mE/L before SSRI) (0,4-3,5)
S-T4 (free) 11pmol/L (10 before SSRI) (8-14)

B-LPK 6,3*10(9)/l (4,5*10(9)/l 2 years ago)

Status of HPA Axis I am not sure. Some good way I could know/test? What do you think?

@Sherpa Thanks, I have started reading your thread. Happy to read about your improvements! Is there any "stark kit" you recommend me trying?

 

[deleder2k]

I am not a doctor, but S-testosteron 22 looks good. I don't know much about the HPA axis, but to figure out if it is working correctly one usually tests testosterone, LH, FSH and possibly something else. If you're testosteron level was low I am sure your doctor would look at FSH and LH. Have you tried cialis/viagra??

 

[PeterSv]

@deleder2k Yes 22 is good. FSH and LH is on the very low range but I don´t know if that is saying something..Nope, I haven´t tried any such. I can get an erection "naturally" sometimes but it is just that I do not get excited or even care about sex and other stuff. I am thinking my neurotransmitter (or receptors) (serotonine/dopamine) levels have been messed up in some way.

 

[adreno]

It seems it's not uncommon for this to happen after SSRI withdrawal. At least the net is brimming with such anecdotes.

Is it a possibility to go back on the SSRI? Why did you discontinue?

Have you tried other serotonin boosting substances, such as SJW or 5-HTP?

 

[PeterSv]

@adreno Yes, there is plenty of such stories.. I didn´t really benefit any from SSRI, only blunted feelings but depressed feelings have I never really suffered from. I am more of an obsessive type and worrier, but I am getting better with therapy and lifestyle changes! I stopped because it was upsetting and frightening with becoming completely blunted. Unfortunately it stayed (it got a little better though).. I have been thinking about reinstating SSRI, adjusting to a good dose and then taper off slowly.

Nope, I have not. I have SJW at home but not tried it. I think it has worked for some but also not for some other.

Any ideas from that?

 

[Valentijn]

see the link in my signature for how I treated MTRR A66G and MAO A R297R

Does MAOA R297R have any impact? It's a synonymous variation in a coding section, meaning it doesn't result in a protein change and probably can't even have a regulatory influence.

 

[Hip]

Any ideas from that?

For serotonergic effects you mean? You might want to look up high dose inositol, for many it can be a good antidepressant and anxiolytic. Plus it is a treatment for OCD, so if you have obsessive tendencies, this treatment might be right up your street.