Matt_C
Senior Member
- Messages
- 128
- Location
- Sydney, Australia
Hi all,
It was recently suggested I may have a MTHFR SNP so I went ahead and had the tests done and was found to be homozygous for C677T. My homocysteine levels are on the low side too, slightly under the bottom end of the range. From everything i've read this means I am not methylating well and should benefit from a methylation protocol. I had CFS for years but resolved most of the symptoms over the years but am still left with chronic insomnia, chronic tiredness, and low energy. So I read around and found Freddd's protocol here, and also a protocol at mthfr.net. They are a little contradictory and so i'm left confused about how to proceed.
Is there a link to some posts that explain what donut hole folate insufficiency actually is? I.e the symptoms? And Folate insufficiency? And Methyl-trap, methyl-block and how to tell the difference between them all?There's a lot of talk about them and everyone seems to know what they are, but I can't find any posts that outline what the symptoms are and how to identify when I need to take more potassium or more methylfolate, etc.
The protocol at mthfr.net also suggests to stop taking methylfolate if you start to feel bad whereas Freddd suggests it's this donut hole folate insufficiency and that even more folate is needed, or potassium at high doses until one starts to feel better. But i'm unsure what to do. I'm not seeing my integrative GP until the 22nd of December so i'm just trying to find as much information as I can online in the meantime.
I've started methylfolate supplements initially at 500mcg a day while I waited for the methylcobalamin, adncbl, potassium, and l-carnitine as they aren't available in Australia. I noticed some changes straight away and then seemed to get quite irritable on the 3-5th day with some mild headaches. I started the mcbl three days ago now and have added a little bit of potassium. Since starting this I have slept right through the night two nights in a row, which is very significant for me, but yesterday and today i've been feeling very tired and heavy headed and today i'm a little off-balance on my feet. Hopefully someone can point me in the right direction.
Cheers,
Matt
It was recently suggested I may have a MTHFR SNP so I went ahead and had the tests done and was found to be homozygous for C677T. My homocysteine levels are on the low side too, slightly under the bottom end of the range. From everything i've read this means I am not methylating well and should benefit from a methylation protocol. I had CFS for years but resolved most of the symptoms over the years but am still left with chronic insomnia, chronic tiredness, and low energy. So I read around and found Freddd's protocol here, and also a protocol at mthfr.net. They are a little contradictory and so i'm left confused about how to proceed.
Is there a link to some posts that explain what donut hole folate insufficiency actually is? I.e the symptoms? And Folate insufficiency? And Methyl-trap, methyl-block and how to tell the difference between them all?There's a lot of talk about them and everyone seems to know what they are, but I can't find any posts that outline what the symptoms are and how to identify when I need to take more potassium or more methylfolate, etc.
The protocol at mthfr.net also suggests to stop taking methylfolate if you start to feel bad whereas Freddd suggests it's this donut hole folate insufficiency and that even more folate is needed, or potassium at high doses until one starts to feel better. But i'm unsure what to do. I'm not seeing my integrative GP until the 22nd of December so i'm just trying to find as much information as I can online in the meantime.
I've started methylfolate supplements initially at 500mcg a day while I waited for the methylcobalamin, adncbl, potassium, and l-carnitine as they aren't available in Australia. I noticed some changes straight away and then seemed to get quite irritable on the 3-5th day with some mild headaches. I started the mcbl three days ago now and have added a little bit of potassium. Since starting this I have slept right through the night two nights in a row, which is very significant for me, but yesterday and today i've been feeling very tired and heavy headed and today i'm a little off-balance on my feet. Hopefully someone can point me in the right direction.
Cheers,
Matt