garyfritz
Senior Member
- Messages
- 599
I have a bunch of methylation-related SNPs -- see my sig. And I have some significant symptoms that respond almost instantly to B12. But I'm not convinced my symptoms are due to methylation or ME.
As I've posted before, I have a ferocious appetite for B12. I'm using a triple dose of the B12oil, which is equivalent to about 4.5mg adenoB12 and 1.5mg methylB12, injected, per day. And sometimes that's not enough. The B12oils guy says he hasn't personally encountered anybody who uses as much as I do.
But I don't think I have ME. I don't show any of the symptoms like exercise intolerance. I can do pretty strenuous exercise (yardwork, hiking, expert skiing, etc) for hours, and not have any unusual / inappropriate problems afterwards. At least nothing unusual for an out-of-shape 60-yr-old.
I'm also not convinced this is a methylation issue. I didn't get any response to Freddd's DQ, except the B12.
So my question is -- what's up with me and B12??
I think it's definitely connected to my SNPs. I've recently started sending my 84-yr-old mother some of the B12oil, and she says she gets immediate relief from it. She also says HER mother used to get B12 injections in the 1950's, and it was always very obvious when her shot was running out. So it definitely seems to be hereditary.
I suspect my symptoms (restless legs, daytime fight/flight-like reactions and crawl-out-of-my-skin feelings, night-time agitation and near-seizure-like twitching/thrashing with nightmarish mental state, etc etc) are just B12-deficiency symptoms. But I'm wondering what causes the deficiency, and if there is anything I can do about it other than shovel in more and more B12. Greg the B12oils guy has suggested several ancillary nutrients (B1, B2, selenium, iodine, others) but none have made any noticeable difference. Only B12 seems to have any effect, and its effect is immediate and dramatic. And BTW I don't seem to be "loading up my tank" of B12 reserves as Greg expected I would. I've been doing the triple-dose for a year now and I'll still see symptoms within a day if I go off the B12. (Though I suppose it's possible I need a 4-5x dose to have enough surplus to start stockpiling it!)
I'm very thankful I found B12 when my lifelong but occasional RLS issues suddenly exploded into a constellation of related symptoms 3-4 years ago. I can't imagine how insane I would be by now without it. And I probably avoided significant neural damage by providing enough B12 to keep my symptoms in check. But I would really like to understand the mechanism behind this. I'd like to know if there's anything I can do to address the problem and prevent it from getting worse as I get older. Any suggestions?
Thanks!!
Gary
As I've posted before, I have a ferocious appetite for B12. I'm using a triple dose of the B12oil, which is equivalent to about 4.5mg adenoB12 and 1.5mg methylB12, injected, per day. And sometimes that's not enough. The B12oils guy says he hasn't personally encountered anybody who uses as much as I do.
But I don't think I have ME. I don't show any of the symptoms like exercise intolerance. I can do pretty strenuous exercise (yardwork, hiking, expert skiing, etc) for hours, and not have any unusual / inappropriate problems afterwards. At least nothing unusual for an out-of-shape 60-yr-old.
I'm also not convinced this is a methylation issue. I didn't get any response to Freddd's DQ, except the B12.
So my question is -- what's up with me and B12??
I think it's definitely connected to my SNPs. I've recently started sending my 84-yr-old mother some of the B12oil, and she says she gets immediate relief from it. She also says HER mother used to get B12 injections in the 1950's, and it was always very obvious when her shot was running out. So it definitely seems to be hereditary.
I suspect my symptoms (restless legs, daytime fight/flight-like reactions and crawl-out-of-my-skin feelings, night-time agitation and near-seizure-like twitching/thrashing with nightmarish mental state, etc etc) are just B12-deficiency symptoms. But I'm wondering what causes the deficiency, and if there is anything I can do about it other than shovel in more and more B12. Greg the B12oils guy has suggested several ancillary nutrients (B1, B2, selenium, iodine, others) but none have made any noticeable difference. Only B12 seems to have any effect, and its effect is immediate and dramatic. And BTW I don't seem to be "loading up my tank" of B12 reserves as Greg expected I would. I've been doing the triple-dose for a year now and I'll still see symptoms within a day if I go off the B12. (Though I suppose it's possible I need a 4-5x dose to have enough surplus to start stockpiling it!)
I'm very thankful I found B12 when my lifelong but occasional RLS issues suddenly exploded into a constellation of related symptoms 3-4 years ago. I can't imagine how insane I would be by now without it. And I probably avoided significant neural damage by providing enough B12 to keep my symptoms in check. But I would really like to understand the mechanism behind this. I'd like to know if there's anything I can do to address the problem and prevent it from getting worse as I get older. Any suggestions?
Thanks!!
Gary
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