It's worth remembering that someone with a clinical diagnosis of 'CFS' may have in addition (or isolation) an undiagnosed POTS or Lyme disorder, and not have the autoimmune subset in CFS at all, or both, or triple conditions all at once.
If and when we hear of people going back to work, or having some kind of life again on Rituximab, be cautious that we don't know yet know how to immunologically select this group of recovered patients as similar or dissimilar to us.
Then add the fact of additional diseases acquired, and longevity. Was the person ill for 5 years or 50 years? It would make sense that overtime, the immune system in some subsets becomes damaged, and that B Cell depletion simply won't work, or is too risky to even attempt if the patient is very weak and/or very chemically sensitive/hyper allergic.
Without wanting to sound dictatorial (apologies if I am) I feel it's worth being realistic over B Cell depletion working for the reason you, personally, are sick rather than getting your hopes up, only for them to be dashed.
Having said that, it's fantastic a subset of patients may be helped significantly or even 'cured' and that is a great moment for the legitimacy of any disease in general, and the folk with forms of the disease who can get some of, or most of their lives back.
Certainly with a subset back on their feet, they will become an effective force for health advocacy also.