One very specific part of the undetectable infection that I believe is key to all of this immune dysfunction is protease.
Now I know one of the moderators specifically attacked the comments I made, there was something mentioned about gardening and tools ..... but what that has done has given me the motivation to research this further. ....
I believe that bacterial protease expression is the missing link and is being overlooked by the researchers
This is why ....
....... Unfortunately, the innate immunity system of mucosal membranes is more easily compromised and most bacterially-mediated infectious diseases begin after breach of this barrier. Nevertheless,only bacteria that are equipped with the appropriate means to bypass, inactivate or hijack host defenses are capable of this activity. The spectrum of virulence traits allowing pathogens to survive the antibacterial activities of innate immunity is astonishing. Some of these tactics rely on proteolytic activity elaborated by the pathogens. This comes as no surprise if one takes into account that the effector and signaling molecules of innate immunity are proteins and peptides that can be inactivated by bacterial proteases.
Those of you who are interested, may find this particular article interesting .....
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743019/
This is why I believe, and have previously stated in this thread, some people recover on anti-viral therapy because anti-viral therapies are generally protease inhibitors .......
Basically, proteases damage the immune systems signallers, so the immune system then doesn't activate when the body is attacked ..... I am just wondering if anybody else here can see how familiar this sounds ......
Putting this in plain english, the bacteria take out the sirens which calls the immune system into action which then allows any pathogen to take up residence ......
Now I know one of the moderators specifically attacked the comments I made, there was something mentioned about gardening and tools ..... but what that has done has given me the motivation to research this further. ....
I believe that bacterial protease expression is the missing link and is being overlooked by the researchers
This is why ....
....... Unfortunately, the innate immunity system of mucosal membranes is more easily compromised and most bacterially-mediated infectious diseases begin after breach of this barrier. Nevertheless,only bacteria that are equipped with the appropriate means to bypass, inactivate or hijack host defenses are capable of this activity. The spectrum of virulence traits allowing pathogens to survive the antibacterial activities of innate immunity is astonishing. Some of these tactics rely on proteolytic activity elaborated by the pathogens. This comes as no surprise if one takes into account that the effector and signaling molecules of innate immunity are proteins and peptides that can be inactivated by bacterial proteases.
Those of you who are interested, may find this particular article interesting .....
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743019/
This is why I believe, and have previously stated in this thread, some people recover on anti-viral therapy because anti-viral therapies are generally protease inhibitors .......
Basically, proteases damage the immune systems signallers, so the immune system then doesn't activate when the body is attacked ..... I am just wondering if anybody else here can see how familiar this sounds ......
Putting this in plain english, the bacteria take out the sirens which calls the immune system into action which then allows any pathogen to take up residence ......