http://www.medicalnewstoday.com/articles/301870.php
Grrrr. Another regurgitation of the PACE follow up .
Grrrr. Another regurgitation of the PACE follow up .
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I am really really tired, barely slept in days, so I omitted references but I posted this:
The study does indeed show that benefits are sustained, kind of. However they are ZERO benefits. GET or CBT were actually SMC+GET and SMC+CBT. At two and a half years there was no benefit using SMC as the comparison.
This is most easily interpreted as the earlier study results in supposed favour of CBT or GET being mostly methodological bias.
Lets look at the objective outcomes. No improvement in fitness, work history, or receipt of benefits. NONE. An objective outcome measure of fatigue was dropped after the study started. Subjecive outcomes show no benefit in fatigue at two and a half years.
Coyne and Tuller, and now Laws, have written damning analyses of this and earlier studies. There is a long litany of methodological problems, from basic methods, to faulty statistical analysis, to recruitment aberrations. Scientists have variously described these studies as "uninterpretable" to its hard to see how they get through peer review.
The most worrying aspect is nearly all these faults are obvious. Someone well trained in analyzing papers should be able to see them immediately.
These studies are not the Gold Standard in evidence based medicine. They fail at too many points.
These failures are without referring to other studies using objective measures of functional capacity from CBT/GET treatments, which show either a worsening outcome or no change. In addition, three government studies of clinics using these methods in the real world, in Holland and Belgium, at least one much larger than the PACE trial, show no benefit or even a decline.
Its time this research was put to rest.
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