Marc_NL
Senior Member
- Messages
- 471
I have read some comments and advise from Rich in the past after the Methylation pathway results, hopefully there are still people here that can understand this and comment:
Glutathione (reduced) 3.0 ref. range: 3.8 – 5.5
Glutathione (oxidized) 0.54 ref. range: 0.16 – 0.50
S-Adenosylmethionine (RBC) 219 ref. range: 221 – 256
S-Adenosylhomocysteine (RBC) 54.0 ref. range: 38.0 – 49.0
Adenosine 24.6 ref. range: 16.8 – 21.4
5-CH3-THF 8.3 ref. range: 8.4 – 72.6
10-Formyl-THF 6.4 ref. range: 1.5 – 8.2
5-Formyl-THF 1.20 ref. range: 1.20 – 11.70
THF 0.49 ref. range: 0.60 – 6.80
Folic Acid 10.6 ref. range: 8.9 – 24.6
Folinic Acid (WB) 7.0 ref. range: 9.0 – 35.5
Folic Acid, active (RBC) 321 ref. range: 400 – 1500
Besides that I took two extra tests:
Homocysteine 7.0 ref. range: 4.5 – 12.4
Methylmalonic Acid (MMA) urine 3.1 ref. range: 0.0 – 2.8 mg/24h (1850 ml)
Most of the values out of range as it "should" be.
Rich’s explanation is here:
http://phoenixrising.me/treating-cf...esults-of-the-methylation-pathways-panel-2011
After doing the test I started with a variation of Rich’s “simple” protocol
- First Yasko’s All-in-One Multivitamin - http://www.holisticheal.com/all-in-one-multi-vitamin-mineral-120-capsules.html
Starting with one capsule and increasing to four capsules (morning 2, afternoon 2)
After four days I started feeling better (didn’t really expect that), I was taking 3 capsules at that time.
I increased to four capsules and also started with:
- NT Factor EnergyLipids Powder (0.8g, oncea day)
http://www.iherb.com/Nutricology-NT-Factor-EnergyLipids-Powder-150-grams/45698
I was still feeling good for about three weeks (clear mind and more energy) so I didn’t add in other supplements.
When it stopped working for me I started adding other thing with some days in between:
- 2000 mcg (2 tablets) Enzymatic Therapy, B12 Infusion, Energy, 30 Chewable Tablets:
http://www.iherb.com/Enzymatic-Therapy-B12-Infusion-Energy-30-Chewable-Tablets/2119
- Source Naturals MegaFolinic 800mcg (1/4 tablet per day) http://www.iherb.com/Source-Naturals-MegaFolinic-800-mcg-120-Tablets/7735#
- Solgar Metafolin 400mcg (1/2 tablet per day) - http://www.iherb.com/Solgar-Folate-As-Metafolin-400-mcg-100-Tablets/14274#
- Later I changed the B12 to 1000 mcg (1 tablet) Enzymatic Therapy, B12 Infusion, Energy and 1000 mcg (1/10 tablet) of Source Naturals, Dibencozide Coenzymated B-12, 60 Tablets
http://www.iherb.com/Source-Naturals-Dibencozide-Coenzymated-B-12-60-Tablets/2454
Besides this I take
- 2 tablets Now Foods, Potassium Gluconate, 99 mg, 250 Tablets
http://www.iherb.com/Now-Foods-Potassium-Gluconate-99-mg-250-Tablets/764
- some omega fish oil
Some dissapointment that what I felt during the first three weeks on the All In One alone did not come back.
I intend to continue this protocol for two months and give it a chance and try some variations after that period.
=========================================
VITAMIN A (AS PALMITATE) 1250 IU
VITAMIN C (AS ASCORBIC ACID) 60mg
VITAMIN D3 (AS CHOLECALICIFEROL) 100 IU
VITAMIN E (AS SUCCINATE) 22.5 IU
VITAMIN K1 (AS PHYTONADIONE) 9mcg
VITAMIN B2 (AS RIBOFLAVIN 5-PHOSPHATE) 3.1mg
VITAMIN B3 (AS NIACINAMIDE) 9.4mg
VITAMIN B6 (AS PYRIDOXINE HCI) 3.1mg
FOLATE (AS FOLIC AND FOLINIC ACID) 20.1mcg
FOLATE (AS QUATREFOLIC®[6S]-5-METHYLTETRAHYDROFOLIC ACID EQUIVALENT TO 6.1 MCG [6S] -5-MEHTYLTETRAHYDROFOLIC ACID, GLUCOSAMINE SALT) 3.4mcg
VITAMIN B12 (HYDROXOCOBALAMIN) 62.5mcg
BIOTIN 38mcg
VITAMIN B5 (AS D-CALCIUM PANTOTHENATE) 12.5mg
CALCIUM (AS CITRATE) 5mg
MAGNESIUM (AS CITRATE) 36.3mg
ZINC (AS METHIONATE) 3.75mg
SELENIUM (L-SELENOMETHIONINE) 25mcg
MANGANESE (AS CITRATE) 0.25mg
CHROMIUM (AS POLYNICOTINATE) 25mcg
MOLYBDENUM (AS CITRATE) 18.8mcg
POTASSIUM (AS CITRATE) 6.25mg
PROPRIETARY SUPPORT BLEND: 215mg
~BROCCOLI POWDER
~L-CARNITINE (as tartrate)
~DOCOSAHEXAENOIC ACID (as DHA™)
~TAURINE
~GARLIC EXTRACT (deodorized)
~N-ACETYL-L-CYSTEINE
~L-METHIONINE
~CITRIUS BIOFLAVONOIDS EXTRACT
~PHOSPHOSERINE (as Sharp PS®)
~MILK THISTLE SEED EXTRACT
~MIXED NUCLEOTIDE
~INOSITOL
~PINE BARK EXTRACT (Pinus maritimus)
~SAME (s-adenosylmethioine)
~STRONTIUM (as citrate)
~BORON (as citrate)
~BENFOTIAMINE
~CURCUMIN (Turmeric Rhizome Extract)
~VANADIUM (as citrate)
~PARA-AMINO BENZONIC ACID (PABA)
~INTRINSIC FACTOR (porcine)
~ASTRAGULUS MEMBRANUS AND PANAX NOTOGINSENG EXTRACTS (as AstraGin™)
~LITHIUM (as orotate)
Glutathione (reduced) 3.0 ref. range: 3.8 – 5.5
Glutathione (oxidized) 0.54 ref. range: 0.16 – 0.50
S-Adenosylmethionine (RBC) 219 ref. range: 221 – 256
S-Adenosylhomocysteine (RBC) 54.0 ref. range: 38.0 – 49.0
Adenosine 24.6 ref. range: 16.8 – 21.4
5-CH3-THF 8.3 ref. range: 8.4 – 72.6
10-Formyl-THF 6.4 ref. range: 1.5 – 8.2
5-Formyl-THF 1.20 ref. range: 1.20 – 11.70
THF 0.49 ref. range: 0.60 – 6.80
Folic Acid 10.6 ref. range: 8.9 – 24.6
Folinic Acid (WB) 7.0 ref. range: 9.0 – 35.5
Folic Acid, active (RBC) 321 ref. range: 400 – 1500
Besides that I took two extra tests:
Homocysteine 7.0 ref. range: 4.5 – 12.4
Methylmalonic Acid (MMA) urine 3.1 ref. range: 0.0 – 2.8 mg/24h (1850 ml)
Most of the values out of range as it "should" be.
Rich’s explanation is here:
http://phoenixrising.me/treating-cf...esults-of-the-methylation-pathways-panel-2011
After doing the test I started with a variation of Rich’s “simple” protocol
- First Yasko’s All-in-One Multivitamin - http://www.holisticheal.com/all-in-one-multi-vitamin-mineral-120-capsules.html
Starting with one capsule and increasing to four capsules (morning 2, afternoon 2)
After four days I started feeling better (didn’t really expect that), I was taking 3 capsules at that time.
I increased to four capsules and also started with:
- NT Factor EnergyLipids Powder (0.8g, oncea day)
http://www.iherb.com/Nutricology-NT-Factor-EnergyLipids-Powder-150-grams/45698
I was still feeling good for about three weeks (clear mind and more energy) so I didn’t add in other supplements.
When it stopped working for me I started adding other thing with some days in between:
- 2000 mcg (2 tablets) Enzymatic Therapy, B12 Infusion, Energy, 30 Chewable Tablets:
http://www.iherb.com/Enzymatic-Therapy-B12-Infusion-Energy-30-Chewable-Tablets/2119
- Source Naturals MegaFolinic 800mcg (1/4 tablet per day) http://www.iherb.com/Source-Naturals-MegaFolinic-800-mcg-120-Tablets/7735#
- Solgar Metafolin 400mcg (1/2 tablet per day) - http://www.iherb.com/Solgar-Folate-As-Metafolin-400-mcg-100-Tablets/14274#
- Later I changed the B12 to 1000 mcg (1 tablet) Enzymatic Therapy, B12 Infusion, Energy and 1000 mcg (1/10 tablet) of Source Naturals, Dibencozide Coenzymated B-12, 60 Tablets
http://www.iherb.com/Source-Naturals-Dibencozide-Coenzymated-B-12-60-Tablets/2454
Besides this I take
- 2 tablets Now Foods, Potassium Gluconate, 99 mg, 250 Tablets
http://www.iherb.com/Now-Foods-Potassium-Gluconate-99-mg-250-Tablets/764
- some omega fish oil
Some dissapointment that what I felt during the first three weeks on the All In One alone did not come back.
I intend to continue this protocol for two months and give it a chance and try some variations after that period.
- So my most important question is of course: what was it in the All in One that made an almost immediate improvement why did it stop working and how can I repeat that?
- I guess the SAMe is a suspect, so would taking some extra SAMe be a good idea, I have also read that if the methylation cycle starts cycling again values like SAMe will automatically come in range and I guess that if your body can start producing it by itself it’s better.
- I read that a high level of Methylmalonic Acid points to lack of aB12, would that indicate that I should take more of the aB12, I also understand that you should not take to much mB12 and mFolate in the beginning not to overdrive things (still according to Rich’s theory), does that also count for the aB12 or can you take as much of this as you can handle?
- Should I try hydroxocobalamin instead of the active forms since that is in the All In One and I just needed more of that?
- Any other suggestions based on the Methylation panel results?
- Any other things in the All In One that might have worked in the beginning?
=========================================
VITAMIN A (AS PALMITATE) 1250 IU
VITAMIN C (AS ASCORBIC ACID) 60mg
VITAMIN D3 (AS CHOLECALICIFEROL) 100 IU
VITAMIN E (AS SUCCINATE) 22.5 IU
VITAMIN K1 (AS PHYTONADIONE) 9mcg
VITAMIN B2 (AS RIBOFLAVIN 5-PHOSPHATE) 3.1mg
VITAMIN B3 (AS NIACINAMIDE) 9.4mg
VITAMIN B6 (AS PYRIDOXINE HCI) 3.1mg
FOLATE (AS FOLIC AND FOLINIC ACID) 20.1mcg
FOLATE (AS QUATREFOLIC®[6S]-5-METHYLTETRAHYDROFOLIC ACID EQUIVALENT TO 6.1 MCG [6S] -5-MEHTYLTETRAHYDROFOLIC ACID, GLUCOSAMINE SALT) 3.4mcg
VITAMIN B12 (HYDROXOCOBALAMIN) 62.5mcg
BIOTIN 38mcg
VITAMIN B5 (AS D-CALCIUM PANTOTHENATE) 12.5mg
CALCIUM (AS CITRATE) 5mg
MAGNESIUM (AS CITRATE) 36.3mg
ZINC (AS METHIONATE) 3.75mg
SELENIUM (L-SELENOMETHIONINE) 25mcg
MANGANESE (AS CITRATE) 0.25mg
CHROMIUM (AS POLYNICOTINATE) 25mcg
MOLYBDENUM (AS CITRATE) 18.8mcg
POTASSIUM (AS CITRATE) 6.25mg
PROPRIETARY SUPPORT BLEND: 215mg
~BROCCOLI POWDER
~L-CARNITINE (as tartrate)
~DOCOSAHEXAENOIC ACID (as DHA™)
~TAURINE
~GARLIC EXTRACT (deodorized)
~N-ACETYL-L-CYSTEINE
~L-METHIONINE
~CITRIUS BIOFLAVONOIDS EXTRACT
~PHOSPHOSERINE (as Sharp PS®)
~MILK THISTLE SEED EXTRACT
~MIXED NUCLEOTIDE
~INOSITOL
~PINE BARK EXTRACT (Pinus maritimus)
~SAME (s-adenosylmethioine)
~STRONTIUM (as citrate)
~BORON (as citrate)
~BENFOTIAMINE
~CURCUMIN (Turmeric Rhizome Extract)
~VANADIUM (as citrate)
~PARA-AMINO BENZONIC ACID (PABA)
~INTRINSIC FACTOR (porcine)
~ASTRAGULUS MEMBRANUS AND PANAX NOTOGINSENG EXTRACTS (as AstraGin™)
~LITHIUM (as orotate)