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Would methylation really help food allergies?

sillysocks84

Senior Member
Messages
445
If I am allergic to onions and garlic and chocolate :cry:all of a sudden, would methylation be something to help? My symptoms are itchiness and tight throat. I get a bump or two on the roof of my mouth at times. I get afraid it will progress to anaphylaxis. Can someone tell me if methylation would help?

In addition, my normal dust allergies are worse. My throat is constantly reactive. I am see an allergist today for my food allergy test and tryptase results. Please help! Methylation looks expensive. I wouldn't even know where to start!:woot:
 

sillysocks84

Senior Member
Messages
445
I want to know if methylation would help. I think my food allergirs are from mast cells reacting and or possible dysfunction in sulfite breakdown.
 

ahmo

Senior Member
Messages
4,805
Location
Northcoast NSW, Australia
@sillysocks84 It's not unusual for people starting methylation protocols to experience or have increased allergies. This tends to be an initial response, is not always the case. But it doesn't look to me as if you have any clear indications for methylation.

Onions, garlic, chocolate: choc is high histamine; the other 2 are high thiol. Any other connections? totally new intolerance? I'd be looking for calming down your mast cells. Royal jelly is the mast cellstabilizer I had great results with. Are you under stress? There's a close connection betw adrenals and mast cell reactions.
 

Gondwanaland

Senior Member
Messages
5,092
In my experience anemia (even if borderline) and unsupported thyroid caused several food intolerances. supplementation of B complex , minerals and thytoid support, all tailored to my specific needs, fixed it.
 

sillysocks84

Senior Member
Messages
445
Onions, garlic, chocolate: choc is high histamine; the other 2 are high thiol. Any other connections? totally new intolerance? I'd be looking for calming down your mast cells. Royal jelly is the mast cellstabilizer I had great results with. Are you under stress? There's a close connection betw adrenals and mast cell reactions.
WHere do you get your royal jelly? I probably am under stress, I know funny to say it that way. I may be in denial on it. We have to move soon, my husband has a brand new business he's running and so I'm taking care of our 2 year old all the time by myself unless I'm at work the 3 half days a week I sit and work at my local library. Which is a relief to have that relaxing job! So now I'm also supposed to start packing. And the vents where we are are soooo dusty! We rent this place (since last January ) . So I'm probably stressed:woot:
 

sillysocks84

Senior Member
Messages
445
In my experience anemia (even if borderline) and unsupported thyroid caused several food intolerances. supplementation of B complex , minerals and thytoid support, all tailored to my specific needs, fixed it.
I've been tested for anemia but not for a while now. I didn't have it then. Also my thyroid test was normal a few months ago, except I don't think they did anything besides looking at tsh levels. So.... not sure what's up with that area of things.

It makes me tired to think of all these possibilities . So many doctors I've seen. I saw my allergist today. He said my tryptase was normal and all my foods on the food test said I wasn't allergic to anything. So I once again explained mast cell to him and he wants me to go see ku medical hospital specialists. AND an ENT to look at possible reflux. AND a gi doctor to look at EoE. He said when I find out what's wrong clue him in.

I so do appreciate all this input though. Because the answer should be somewhere, right?
 

ahmo

Senior Member
Messages
4,805
Location
Northcoast NSW, Australia
Oh, so your stress is just beginning. :meh: In the words of mast cell expert Dr. Theoharides, the mast cell is the canary of the body. You might be able to find rj in grocery or chemist/pharmacy. I get mine from iherb, California Gold.

Here's from an excellent article:
https://mastcellblog.wordpress.com/2013/11/12/canary/

Therapy

Can anything stabilize mast cells and stop them from being quite so trigger happy (we can’t disable them altogether otherwise we’d have no immunity and the first pathogen we came across would kill us)? The answer is currently a rather weak “yes”, but much better drugs are needed.

As mentioned, currently available anti-histamines can help with symptoms attributed to histamine mediator release such as insomnia, reflux, asthmatic issues, IBS. However, although they stop histamine binding to H1 and H2 receptors, they still leave the histamine floating around the body where it’s free to bind to H3 and H4 receptors causing other symptoms. The first generation anti-histamine http://en.wikipedia.org/wiki/Hydroxyzine, however, crosses the blood-brain barrier and acts as both an anti-histamine and mast cell stabilizer. It has been shown to inhibit allergic encephalomyelitis and associated brain mast cell activation in animals[5]. It is also useful for anxiety (possibly as a result of CNS activation through mast cells), but can be very sedating.

To reduce the amount of histamine the body has to cope with you could, like me, try following a low histamine diet. But again, this only deals with histamine not the other 29 mast cell mediators. For that, you need to stop mast cells from unnecessarily spilling their mediator contents in the first place.

Sodium chromoglycate stabilizes mast cells in the skin and GI tract but cannot penetrate the blood-brain barrier. SC may be useful if you have persistent GI symptoms such as cramp, nausea, diarrhoea, or persistent allergy-type symptoms such as food intolerance, chemical sensitivity, asthma/breathing problems etc. A table of other drugs currently used to treat MCAD can be found within http://www.ehoonline.org/content/pdf/2162-3619-2-28.pdf.

http://en.wikipedia.org/wiki/Luteolin is a flavanoid which is an anti-oxidant, anti-inflammatory, mild metal chelator, mast cell inhibitor and is neuro-protective – it crosses the blood-brain barrier where sodium chromoglycate does not. You can buy luteolin in capsule/powder form, however only 5% goes into the bloodstream. Ideally a much better way of getting luteolin into the brain is needed. Dr Theoharides has developed a non-prescription capsule called http://www.algonot.com/neuroprotek.php which contains Lutoelin, and 2 other flavaoids known for their mast cell stabilizing properties http://en.wikipedia.org/wiki/Quercetin and http://en.wikipedia.org/wiki/Rutin, mixed with olive kernel oil which helps the body deliver and absorb the flavonoids. This is not a cure for mast cell disease but may help the severity of symptoms. (Note: Dr Theoharides makes no money from the sale of Neuroprotek).

Luteolin, Quercetin and Rutin are also found in various foods, so it can’t do anything but good to include these in the diet:

    • Luteolin is present in celery, green pepper, parsley, thyme, dandelion, chamomile tea, carrots, olive oil, peppermint, rosemary and oregano.
    • Quercetin is found in many foods, particularly buckwheat, blueberries, red grapes, red onion, capers, dill, watercress, kale and sweet potato.
    • Rutin is found in buckwheat, asparagus, citrus fruits, apple and berries such as cranberry.
Other treatments

There have been some exciting recent developments in M.E. treatment in a trial using the anti-cancer drug http://bergento.no/cancer-treatment-cfs/. Rituximab works on b-lymphocytes and, strangely enough, b-lymphocytes are controlled by mast cells. The anti-cancer drug http://en.wikipedia.org/wiki/Imatinib has been used by Dr Afrin to treat MCAD (as discussed in his http://www.mastocytosis.ca/2011 MSC Medical Lecture with Slides.pdf) with great success. Strange that these two very similar drugs have been used to treat the same symptoms in two supposedly separate diseases!

Low dose http://www.lowdosenaltrexone.org/ (an immune modulator) has also been used with some success by people suffering from M.E. And, again, Naltrexone is also used to treat MCAD.

Some of the drugs generally used to treat the symptoms in M.E. have mast cell mediator properties. For example, some people find the anti-depressants Zispin, Doxepin and Amitriptylene helpful for both pain and insomnia – the reason being they all have anti-histamine properties (I didn’t have any problems at all with hives or itching until I became allergic to Zispin and had to stop taking it – then my hives appeared apparently ‘out of no-where’). Some people have found a reduction in M.E. symptoms by taking high doses of Vitamin C – the reason being Vitamin C is a mast cell stabilizer (and used quite widely by people with MCAD and Mastocytosis). The reason these drugs help but don’t cure M.E. is that they’re a sticking plaster over symptoms caused by mast cell mediators, but don’t get to the root of the problem which in my very humble, and totally non-medical opinion, is mast cell activation.
 

sillysocks84

Senior Member
Messages
445
@ahmo Thank you so much for that. Losing hope today after my doctor said he couldn't help and to let HIM know what I find out. Well, i kinda knew that response was coming. He was very nice and seems he wants to learn more.

So THANK YOU for that except- it was a hope inspiring read. It seems ritux may be close to a cure for mcas. But maybe I can get it under control, I wonder if these things ever go away on their own like they say me/cfs/pots can do sometimes?

I'm sorry for ranting my stresses at you! I think I have more pent up stress than previously thought. I should start meditation.
 

ahmo

Senior Member
Messages
4,805
Location
Northcoast NSW, Australia
Yes, check out her whole site. She has EDS, collected a lot of info. Now you can chill:cool:...w/ your toddler:whistle:

Ritux might be perfect. You might get just as good results singing or dancing as forcing yourself to sit.;)
 

sillysocks84

Senior Member
Messages
445
@ahmoThank God he's asleep right now. Haha. And funny, I do a lot of singing with my son and it at least makes my mood better.
 

Gondwanaland

Senior Member
Messages
5,092
Not as well as I'd like to be. I go in cycles with that. To be honest.
Well, I have an autoimmune disease and went 100% gluten free back in 2013. My reflux is gone, and also autoimmune activations (mainly body pain) have diminished. Unfortunately gluten isn't the only trigger.
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
If your allergy tests are negative, you have an intolerance, not an allergy. You may notice that it is dose dependent. More of those foods means more of a reaction.
Moderate fasting (only water for 2-4 days) is the most effective treatment that I know of, but it should not be undertaken without doctors permission. See my histamine intolerance journal for more info and my story. Sorry, but I'm on my phone in an airport and can't give you the link. It has given me back my life, but I think that doing a 4R gut rebuilding program first, for 8 weeks, was probably instrumental in my success. But if you don't have the same gut biota issues, it may not be something you need.
Best wishes!
 

sillysocks84

Senior Member
Messages
445
If your allergy tests are negative, you have an intolerance, not an allergy. You may notice that it is dose dependent. More of those foods means more of a reaction.
Moderate fasting (only water for 2-4 days) is the most effective treatment that I know of, but it should not be undertaken without doctors permission. See my histamine intolerance journal for more info and my story. Sorry, but I'm on my phone in an airport and can't give you the link. It has given me back my life, but I think that doing a 4R gut rebuilding program first, for 8 weeks, was probably instrumental in my success. But if you don't have the same gut biota issues, it may not be something you need.
Best wishes!
Thank you, do you think it would hurt trying some probiotics like clostridium butyricum, without talking to my doctor? I know that one is supposed to help mast cells.
 

buggier

Hating my life
Messages
9
Location
Singapore
What are the actual symptoms? Is it a IgG or IgE mediated response?
If its IgE-mediated (meaning it is immediate, most commonly through rashes), consider supplements or herbs to dial down your Th2 immune response.
If you decide to try probiotics, take some RS with it to help shuttle it through stomach acid.
 

Gingergrrl

Senior Member
Messages
16,171
I am see an allergist today for my food allergy test and tryptase results.

Sorry am too tired to reply to all the posts in detail but were you also tested for histamine and prostaglandins and other markers for MCAS? Tryptase is a marker for Mastocytosis (which is a mast cell disease in which you have too many mast cells and is a form of cancer.) I do not have this one and my tryptase levels are always totally normal.

However, I have severe MCAS and my histamine blood level back in Dec 2014 was 3x the normal level. This means I have the normal number of mast cells but the ones I have are behaving badly. My prostaglandin level was also very high. I did not develop symptoms until March/April this year when all hell broke loose and my life has been turned upside down ever since. But in reading all the symptoms of MCAS, I had many in a minor form but never made the connection until I started getting anaphylaxis and trying to figure out how the heck to fix this.

Mastocytosis and MCAS symptoms and treatment can be identical but the cause is different and Mastocytosis (besides tryptase levels) can only be definitively confirmed by a bone marrow biopsy. Hope this helps!