http://forums.phoenixrising.me/index.php?threads/mixing-b12-types-and-brands-ratios.31434/
At long last I have some approximate answers about the effects of ratios of different brands and forms of b12. This is a question that has been up for a long time. It may explain why CyCbl and HyCbl appear able to block MeCbl and AdoCbl. As I have suspected for some years AdoCbl also can block MeCbl.
Through the years various people have indicated a need for different proportions of AdoCbl to MeCbl. I had started out with AdoCbl once a week and up to daily at every dose in a mix. I have found that if the amount of the lesser quantity falls below 20% or so it appears to have no effect. So at 50-50 both have some effect for me but not optimal. The same happens with a 5 star MeCbl combined with a less effective brand. When the 5 star MeCbl gets down to 20% or so of total all it’s specific benefit goes away and startup can happen all over again.
So CyCbl and HyCbl can block MeCbl and/or AdoCbl when either of those falls below 20%. AdoCbl can block MeCbl at 20%. MeCbl can block AdoCbl at 20%. but then behaves like straight MeCbl with some limited conversion to AdoCbl. Three star MeCbl can block 5 star MeCbl at the same 20% or so.
So for me now, I am back to a single dose of AdoCbl a week, just as I had accidently found 10 years ago. I take a single dose of 25-50mg aver several hours in place of one of my MeCbl injections. I’m still trialing the optimum amount. The point is for it to be fully effective it has to be the more than 50% type of b12 in circulation for several hours. Too much AdoCbl for too long and I go into partial methylation block or worse.
However, it takes trials for an individual to determine what is optimum ratios for themselves. Based on very limited experience I would be inclined to say take the doses of different kinds of B12 at different times per day so that each can be distributed best to the tissues.
For me, that appears to be substituting one 25-50mg sublingual dose over 3-4 hours of AdoCbl for one 10mg MeCbl injection each week.
...Lot’s of people have asked me what the “ideal” ratio between AdoCbl and MeCbl is and I could only tell them that different people have different results. Now I can say “It is individual, within certain limits. That blocking can occur with MeCbl, whether made in the body from other forms or from supplements explains a lot of puzzling research results through the years. It also explains the necessity of Transcobalamin III (holotranscobalamin III when cobalamin attached) to mop up and deliver to the liver for excretion all non active forms of cobalamin. The study in 1959 that actually identified the REAL B12s through x-ray crystallography determines that AdoCbl and MeCbl made UP OVER 98% of all cobalamins in liver extract instead of that mistake that named the ineffective and even dangerous CyCbl as “B12” in 1948 and received the Nobel Prize for it.
So, inactive cobalamins can block MeCbl if it is too low a percentage of total cobalamins causing partial methylation block or even methyltrap. People taking CyCbl and/or HyCbl still get hundreds of MeCbl and AdoCbl deficiency symptoms up to and including Subacute Combined Degeneration without hypothesizing the necessity of Cobalamin A, B, C ,D etc type genetic polymorphisms. Now it can be modeled effectiverly via pharmacokinetic methods and make sense with one more factor added, which will be my next post on how folate effectiveness status affects serum half life of cobalamins.
...‘Im taking 50mg a week generally, but as a single long dose. I find I need to get to that higher level to get the diffusion into the CNS. 10mg a day for me, doesn’t penetrate the CNS adequately. My daughter needed a dose a day AdoCbl, with a higher dose being more effective. So this one is very individual in how it is dosed. I also find a daily dosing more effective if it is the entire dose one time a day rather than mixed at the same time with MeCbl. I find that works better alone also. Each way of taking it can produce different effects. The question is “Which is better for me over time?” Changing the balance of AdoCbl/MeCbl affects mood, personality and energy.
It is a difficult climb out of the hole. When I started healing 11 years ago I had no idea that it could possibly end up as successful as it has been. For me it is learning to manage the metabolic and nutritional quirkiness of my body. First there are the hit’em over the head symptoms. The last 5 years it has been much more subtle, learning what gets in the way of the healing the rest of the way. When I don’t get enough of xxxx then that specific deficiency or insufficiency increases symptoms. Learning that many things are subtle, not hard core deficiencies, but rather just not optimum, was important. It’s like learning that folate insufficiency happens in about 6 levels in the body and some can be insufficient at the same time as other layers are fully sufficient. That is confusing for many that one can have both characteristics at the same time; paradoxical. Keeping things going smoothly and finding additional things that can provide incremental improvement is what I have been trying to do for 11 years. Mostly it is a long term following of clues. Each time something is added other things need to be re-evaluated be because they all affect each other.
I actually remember reading it a long time ago but it's a keeper and I'd forgotten it.