- Messages
- 14
Hi everyone
Short version: what symptoms should one expect with an ACAT1-02 mutation (heterozygous or homozygous)?
Long version:
I'm new here and have been reading and learning with great enthusiam, having recent gotten my 23andme results. I immediately started down the MTHFR treatment road (being C677T homozygous) taking methylcobalamin and methylfolate, as per Ben Lynch, but had to rein it back as I started getting some very strong reactions (intense neck and shoulder pain, awake all night), which I later realised were due to my CBS A360A homozygous mutation. Researching further, I found (thanks @caledonia !) some advice here that I actually need to treat ACAT even before I start the CBS protocol - going backwards to go forwards, if you will. However, as I am only heterozygous with ACAT1-02, and don't have obvious gut issues (apart from the occasional belch), I'm not quite clear what to expect with ACAT. I haven't found a description of expected symptoms. As I also have BHMT-08 ++ and BHMT02 +/-, I am considering taking Amy Yasko's supplement, but like to know what to expect before proceeding.
I'm also MAO A R297R ++, and heterozygous for a couple of others (CYP2D6, both NAT2's, both VDR's, SOD2 and MTRR A66G).
Thanks to everyone involved for a great resource. I'm feeling very optimistic about healing.
Brian
Short version: what symptoms should one expect with an ACAT1-02 mutation (heterozygous or homozygous)?
Long version:
I'm new here and have been reading and learning with great enthusiam, having recent gotten my 23andme results. I immediately started down the MTHFR treatment road (being C677T homozygous) taking methylcobalamin and methylfolate, as per Ben Lynch, but had to rein it back as I started getting some very strong reactions (intense neck and shoulder pain, awake all night), which I later realised were due to my CBS A360A homozygous mutation. Researching further, I found (thanks @caledonia !) some advice here that I actually need to treat ACAT even before I start the CBS protocol - going backwards to go forwards, if you will. However, as I am only heterozygous with ACAT1-02, and don't have obvious gut issues (apart from the occasional belch), I'm not quite clear what to expect with ACAT. I haven't found a description of expected symptoms. As I also have BHMT-08 ++ and BHMT02 +/-, I am considering taking Amy Yasko's supplement, but like to know what to expect before proceeding.
I'm also MAO A R297R ++, and heterozygous for a couple of others (CYP2D6, both NAT2's, both VDR's, SOD2 and MTRR A66G).
Thanks to everyone involved for a great resource. I'm feeling very optimistic about healing.
Brian