This is presumably from the FINE Trial. Note: The protocol said fatigue would be analysed using the bimodal scoring system. As there was no difference in fatigue using this scoring method at 70 weeks, they have presumably switching to the likert scoring method.
29th Conference of the European Health Psychology Society
http://www.ehps2015.org/files/EHPS2015_Conference_Abstracts_27082015.pdf
29th Conference of the European Health Psychology Society
http://www.ehps2015.org/files/EHPS2015_Conference_Abstracts_27082015.pdf
Symposium Abstracts
The relationship between sleep problems and fatigue in chronic fatigue syndrome (CFS)
A. Wearden1 2
S. Kyle 1 2
R. Emsley 1 3
1 University of Manchester, School of Psychological Sciences, United Kingdom
2 Manchester Centre for Health Psychology, United Kingdom
3 University of Manchester, Institute of Population Health, United Kingdom
Background
Sleep symptoms are common in chronic fatigue syndrome (CFS). We aimed to describe sleep
symptoms and their relationship to fatigue, and to determine whether improvements in sleep mediated
treatment effects on fatigue.
Methods
296 adult participants in a randomized controlled trial which compared pragmatic rehabilitation with
treatment as usual for CFS completed questionnaire measures of sleep symptoms and fatigue at
baseline, end of treatment (20 weeks) and 70 weeks follow up.
Findings
At baseline, 274 (93%) patients scored within the clinical range for at least one sleep symptom, with
260 (88%) reporting waking unrefreshed. Sleep symptoms and fatigue were weakly correlated
(r=.192). Regression analyses, controlling for relevant baseline variables and treatment allocation,
showed that the beneficial effect of pragmatic rehabilitation on fatigue at follow up was partially
mediated (29%) by improvements in sleep at the end of treatment (effect size -0.94, SE= 0.44,
P=.034).
Discussion
Improvements in sleep may be one mechanism by which pragmatic rehabilitation improves fatigue.
Future work will test multiple mediation models including sleep and previously described cognitive
mediators of pragmatic rehabilitation.