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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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New Scheibenbogen Study - IgGs and SNPs.

Marco

Grrrrrrr!
Messages
2,386
Location
Near Cognac, France
Conclusion
Our results indicate a relationship of COMT polymorphism rs4680 with immune dysregulation in CFS providing a potential link for the association between stress and infection susceptibility in CFS.

Interesting.
 

msf

Senior Member
Messages
3,650
I guess the question is, what is causing the increased levels of cortisol in the ME/CFS patients with COMT mutations?
 
Messages
15,786
I think it's a case of comparing enough things until something shows up. It looks like being Met/Met homozygous for rs4680 resulted in significantly higher cortisol when compared to the heterozygous type, but not when compared alone to the other Val/Val homozygous type. And the mean values were the same for the IgE types, but they're making a big deal out of high out-liers in a combined Met/Met and Met/Val group while sort of ignoring that there were a ton of very low values as well.

On the plus side, the patients had both CCC and Fukuda ME/CFS.

But overall, I don't think they've found anything of particular interest, if anything at all.
 

Snow Leopard

Hibernating
Messages
5,902
Location
South Australia
The findings aren't necessarily 'wrong', just not relevant with respect to ME...

The Met/Met allele association with higher cortisol is interesting, but lack of specificity or sensitivity of this finding as a predictor of CFS is a problem. Likewise for the other findings...
 

bertiedog

Senior Member
Messages
1,738
Location
South East England, UK
I'll be honest I am not really understanding this too well but I do know that my result was AA which equates to Val/Val which I don't understand! Can anyone enlighten me?

BTW I have extremely low cortisol, almost Addison's level and am on 6mg Pred daily and I also have a rubbish immune system and pick up frequent viruses.

Pam
 
Messages
15,786
I'll be honest I am not really understanding this too well but I do know that my result was AA which equates to Val/Val which I don't understand! Can anyone enlighten me?
There's not anything you can conclude about that, based on the study. Like @Snow Leopard said, there's not really any relevance to ME/CFS. And there's not any direct relevance to the genotypes either.