http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4053.html
from a NYT article about the findings:
http://www.nytimes.com/2015/07/19/opinion/sunday/why-science-needs-female-mice.html?_r=1
Abstract from the study:
from a NYT article about the findings:
http://www.nytimes.com/2015/07/19/opinion/sunday/why-science-needs-female-mice.html?_r=1
...
A new study published in the journal Nature Neuroscience suggests that research done on male animals may not hold up for women. Its authors reported that hypersensitivity to pain works differently in male and female mice. For males, immune cells called microglia appear to be required for pain hypersensitivity, and inhibiting their function also relieves the pain. But in female mice, different cells are involved, and targeting the microglia has no effect. If these differences occur in mice, they may occur in humans too. This means a pain drug targeting microglia might appear to work in male mice, but wouldn’t work on women.
...
Abstract from the study:
Different immune cells mediate mechanical pain hypersensitivity in male and female mice
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
- Robert E Sorge,
- Josiane C S Mapplebeck,
- Sarah Rosen,
- Simon Beggs,
- Sarah Taves,
- Jessica K Alexander,
- Loren J Martin,
- Jean-Sebastien Austin,
- Susana G Sotocinal,
- Di Chen,
- Mu Yang,
- Xiang Qun Shi,
- Hao Huang,
- Nicolas J Pillon,
- Philip J Bilan,
- YuShan Tu,
- Amira Klip,
- Ru-Rong Ji,
- Ji Zhang,
- Michael W Salter
- & Jeffrey S Mogil
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