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A few months ago, my doctor tested me for MTHFR. I came back homozygous for 677T, and she started me on a regimen of 1000 mcg methylcobalamin, tapered up to 5000mcg over a month. Then I started taking 400mcg methylfolate and tapered up to 800mcg over a month. During that time I started feeling incredibly toxic. My muscles were sore, I couldn't exercise because I was so tired, and I cried multiple times per week which was extremely unusual for me (having never really cried much in my life).
After two months, I stopped the supplements and felt better the next day. During that time I did some research and got my genes tested by 23andme using the v4 chip. Here are some of my results:
VDR Taq +/-
MAO A R297R +/+
MTHFR 677T +/+
MTRR A66G +/-
MTRR K350A +/-
BHMT-02 +/+
BHMT-08 +/+
ACHY-01 +/-
ACHY-19 +/-
After getting these results I started on Rich's protocol, taking the following supplements early in the morning:
2000mcg hydroxocobalamin
200mcg methylfolate
Yasko's All-in-One (1x)
Yasko's BeCalm spray (6x)
Yasko's Phosphatidyl Serine Complex (1x)
Vitamin D 4000 IU
It has been about two weeks since I started. I feel good in the mornings, but I crash about 8 hours after taking my supplements. For the next 6 hours until bedtime, I become extremely fatigued, sad (often wanting to cry), unable to move around much, and my brain gets foggy and I have difficulty stringing thoughts together. Sometimes I have difficulty speaking properly -- I mispronounce words or combine multiple words together. That never happened to me before starting the protocol.
I would be grateful for any help figuring out what is causing this afternoon crash, and whether or not my current protocol makes sense based on my genetic mutations.
After two months, I stopped the supplements and felt better the next day. During that time I did some research and got my genes tested by 23andme using the v4 chip. Here are some of my results:
VDR Taq +/-
MAO A R297R +/+
MTHFR 677T +/+
MTRR A66G +/-
MTRR K350A +/-
BHMT-02 +/+
BHMT-08 +/+
ACHY-01 +/-
ACHY-19 +/-
After getting these results I started on Rich's protocol, taking the following supplements early in the morning:
2000mcg hydroxocobalamin
200mcg methylfolate
Yasko's All-in-One (1x)
Yasko's BeCalm spray (6x)
Yasko's Phosphatidyl Serine Complex (1x)
Vitamin D 4000 IU
It has been about two weeks since I started. I feel good in the mornings, but I crash about 8 hours after taking my supplements. For the next 6 hours until bedtime, I become extremely fatigued, sad (often wanting to cry), unable to move around much, and my brain gets foggy and I have difficulty stringing thoughts together. Sometimes I have difficulty speaking properly -- I mispronounce words or combine multiple words together. That never happened to me before starting the protocol.
I would be grateful for any help figuring out what is causing this afternoon crash, and whether or not my current protocol makes sense based on my genetic mutations.
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