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Has anyone used Inositol IP6 - Increases NK cells and may other helpful attributes

SunMoonsStars

Senior Member
Messages
159
(NaturalNews) The anticancer effects of IP6 are turning out to be nothing short of astounding. Research is showing that besides reducing cell proliferation and increasing the differentiation of malignant cells, IP6 can often restore cancerous cells to normality.

What is IP6?

IP6, also known as inositol hexophosphate or phytic acid, is a sugar molecule with six phosphate groups attached. It is composed of inositol (one of the B vitamins) bound with six molecules of phosphorous. IP6 was first identified in 1855, but has only recently been researched as a preventative and cure for cancer as well as heart and liver diseases, kidney stones, Parkinson's disease, and more. It is also a powerful antioxidant, immune system enhancer, and booster of natural killer cells. Foods that are significant sources of IP6 include dried beans, whole grains, nuts, seeds, rice, wheat germ, corn and sesame.

Dr. Abulkalam Shamsuddin, a scientist at the University of Maryland School of medicine has been the pioneer researcher of IP6, beginning his work on the compound in the late 1980's. He discovered the ability of IP6 to control the rate of abnormal cell division even when administered long after cancer was induced. He then proved that IP6 normalized the sugar production of cancerous cells, thereby altering the gene expression toward a more healthful state. This proven ability to change cancer cell physiology had major implications, since cancer cells that are well behaved have far less negative impact on health.

Although IP6 has been proven to boost Natural Killer (NK) cell activity, for Shamsuddin the value of IP6 lies not in its ability to augment the immune system, but rather its ability to directly affect the physiology of cancerous cells. Whereas most cancer research has focused on killing or destroying cancer cells, Shamsuddin's research focused on taming or controlling the condition to the point where normality could be restored.

How IP6 works to Protect Against Cancer

Here are several ways IP6 is known to prevent and fight against cancer. IP6 is a very common intracellular messenger, meaning that it controls and influences many cellular activities:

Normalizes the Rate of Cell Growth – Cancer cells lose their control mechanisms and typically divide too rapidly, resulting in great numbers of cells that have a devastating impact on health. IP6 slows or normalizes the rate at which cancer cells divide. It reestablishes control in cells that by definition have lost their control mechanisms due to gene mutation.

Helps to normalize cell physiology – How a cancer cell expresses itself largely determines how threatening it is. Experiments have shown that IP6 normalizes several aspects of cell physiology in spite of the fact that these cells have altered DNA. In many instances, DNA repair is achieved.

Enhances NK cells – NK cells are white blood cells that help to protect against virally infected or cancerous cells. Researchers believe that the higher the NK activity, the lower the incidence of some cancers. The healthy human produces 500 to 1000 cancer cells daily. NK cells and programmed cell death (apoptosis) result in the vast majority of these cells being destroyed and removed. During time of stress, NK activity is compromised, and this is why there is a link between stress levels and cancer. IP6 is able to increase NK cells during these periods. Although many supplements claim to increase NK activity, for IP6 these claims have been documented and proven.

Increases tumor suppressor P53 gene activity - DNA contains tumor suppressor genes that inhibit pathways or processes that allow cells to become cancerous. The p53 gene acts as a control to preventing genetically damaged or cancerous cells from growing and propagating. If the p53 gene becomes damaged or compromised, cancers can establish themselves more readily. IP6 has been shown to greatly increase the amount of p53 gene activity, up to 17 times. When augmented by IP6, "standard of care" treatments become more effective due to this increase in p53 gene activity.

Inhibits inflammation – The level of systemic inflammation is an important indicator in determining cancer survival prognosis. Inflammation results in the release of cytokines, chemical messengers that trigger reactions that enable normal cells to grow and repair themselves. Cytokines can also cause cancer cells to grow. IP6 has been shown to significantly inhibit inflammation.

Exhibits potent antioxidant activity – Antioxidants are known to protect against various disease states and aging in general. Oxidative damage to DNA leaves cells susceptible to mutation that can result in cancerous cells being produced. IP6 has been shown to be a significantly more potent antioxidant than green tea.

Enhances apoptosis (programmed cell death) – Programmed cell death is orderly and results in the removal of individual cells without affecting the surrounding cells. It is a normal part of growth and the maintenance of healthy tissues. It removes unwanted cells so that inflammation or immunological reactions do not result. Cancerous cells are resistive to normal cell apoptosis. This is one mechanism of tumor formation. IP6 has been shown to enhance the natural apoptosis of cancer cells.

Affects angiogenesis – Angiogenesis is the process by which tumors set up their own blood supply, assuring the nutrients necessary to fuel their growth. Once this blood supply is set up, tumor growth spirals as more growth leads to more establishment of blood supply. IP6 inhibits this process, resulting in the starvation of cancer cells.

Inhibits metastasis – IP6 inhibits the adhesion of cancer cells to the extra-cellular matrix proteins, thereby leading to an inhibition of cell migration and invasion. Limiting adhesion is very important after surgeries and biopsies, as these procedures can cause cancer cells to become dislodged. One reason that so many breast cancer patients are found to have lymph nodes containing cancer cells is that mammography can dislodge cancer cells which then migrate to the lymph nodes.

Pharmaceutical research is geared to the development of drugs to treat cancer utilizing these mechanisms. Many of the substances being developed and tested are newly created molecules, having never before appeared in nature. As a result, severe side effects are common place. IP6 already exists in human cells and is easily recognized by the body, so side effects, if any, are rare.

Recent research findings document these mechanisms

The frequency and depth of research into IP6 is expanding at a rapid rate. Here are some of the most recent findings.

The Journal of Clinical Cancer Research, reports a study evaluation the in vivo cancer preventative efficacy of IP6 against prostate tumor growth and progression. Prostate cancer was induced in male mice that were then given either water containing IP6 or plain water. IP6 inhibited prostate cancer progression at the neoplasia state and strongly reduced the incidence of adenocarginoma. The incidence of well-differentiated and poorly differentiated adenocarcinomas in the IP6-fed group were reduced by 44% and 62% respectively. Analysis of the prostate tissue showed a 3.5-fold increase in apoptotic cells. The researchers concluded that these findings are highly significant in establishing for the first time that oral IP6, without toxicity, suppresses prostate tumor growth and progression at the neoplastic state, the state of abnormal or uncontrolled growth.

A study conducted in China and reported in Wei Sheng Yan Jiu explored the effect and mechanism of IP6 on cell proliferation in human gastric carcinoma. They found that IP6 inhibited malignant cell growth in a dose and time dependent manner. The proliferation of gastric carcinoma cells inhibited by IP6 was associated with apoptosis through altered gene expression.

The Brazilian journal, Acta Cirurgica Brasilerira reported a study to determine the modulation effect of IP6 in the biological immunohistochemistry expression of cellular signaling marker apoptosis in a model of induced colon cancer. They found that IP6 was effective in promoting modulation of biological markers in colon cancer.

Another study reported in Acta Cirurgica Brasilerira analyzed of the influence of IP6 on the transcription of genes coding for tumor necrosis factor-alpha and its receptors in a human colon cancer cell line. The results showed that IP6 modulated the expression of the listed genes at transcription level in a dose and time dependent manner.

The journal Neurochemistry Research reported a study of the impact of IP6 as a therapeutic agent on glioblastoma, the deadliest brain tumor in humans and the one currently being battled by Senator Kennedy. Researchers found that the viability of glioblastoma cells decreased following treatment with increasing doses of IP6. The treated cells showed morphological and biochemical features of apoptosis.

Laryngoscope reports a study that found IP6 effective at promoting nuclear factor-kappa B, an early response gene that is associated with head and neck squamous cell cancer. This increased gene expression resulted in reduced cell proliferation and increased cell death.

IP6 is more than a cancer treatment

In addition to the anti-cancer benefits of IP6, ongoing research is revealing its promise as a treatment for diabetes, depression, osteoporosis, heart disease, and kidney stones.

A very recent study reported in the Journal of Toxicology considered the effect of IP6 on Parkinson's Disease. Disrupted iron metabolism and excess iron accumulation has been reported in the brains of Parkinson's patients. Because excessive iron can induce oxidative stress and result in neuronal degradation in Parkinson patients, researchers sought to determine the protective effect of IP6, a natural chelator of iron. They found a 45% reduction in DNA fragmentation with the use of IP6, and protection in the differentiated cells. They concluded that IP6 offered a significant neuro-protective effect.

Supplementing with IP6

IP6 has been shown to be quite safe to use. It is naturally present in mammalian cells, and it is obtainable from food. However, in food, IP6 is bound to protein. Before it can be absorbed it must be freed from this protein. An enzyme called phytase that is present in both food and the intestinal tract performs this function. The problem is that the power of the phytase enzyme is damaging to the IP6 and renders much of it inactive and therefore less effective. Pure IP6 from a supplement is not protein-bound and is easily absorbed in tact, and able to provide its complete medicinal properties. Research has shown that when fiber from All Bran was added to the diet of rats with mammary cancer it was much less effective than the equivalent amount of IP6 added to their drinking water.

Many holistic healers and naturopaths recommend IP6 as both a preventative and treatment for cancer. It is becoming standard alternative treatment to recommend it for anyone with a high risk of cancer or who has had cancer and is looking to prevent a recurrence. Some traditional physicians are also becoming aware of the potential of this compound and although they are loath to abandon their traditional treatments, they are adding IP6 to their protocols.

IP6 is available in capsules or powered form. The capsules provide what is considered to be a maintenance or preventive dose of 2 capsules twice a day. The powered form allows for easy dosing at the therapeutic level which is one scoop mixed with water twice a day. IP6 should be taken on an empty stomach. IP6+Inositol from Cell Forte is the most economical and readily available brand. It is sold online at Vitacost.

Sources:

"Complementary Therapies", University of Texas MD Anderson Cancer Center.

Dr. Kim Vanderlinden, Dr. Ivana Vucenik, Too Good to be True?

About the author
Barbara is a school psychologist, a published author in the area of personal finance, a breast cancer survivor using "alternative" treatments, a born existentialist, and a student of nature and all things natural.

Learn more: http://www.naturalnews.com/024635_IP6_cancer_research.html#ixzz3b1mEDeae
 

SOC

Senior Member
Messages
7,849
While I agree IP6 may help with low NK cell function, I'd look for a better source of info.
About the author
Barbara is a school psychologist, a published author in the area of personal finance, a breast cancer survivor using "alternative" treatments, a born existentialist, and a student of nature and all things natural.
This does not sound like someone to be taking medical advice from. ;)
 

SunMoonsStars

Senior Member
Messages
159
IP6 - Inositol Hexaphosphate: Overview
Alternative Names: Also called Phytic Acid and InsP6.

Inositol Hexaphosphate (IP6) has, in research since 1985, inhibited the onset and progression of cancers in animals, but supportive research in humans is lacking. All research suggesting beneficial effects from taking IP6 involve animals and not humans. It is not known whether IP6 would be useful for the treatment of human disease or, if so, what would be the optimal amount.

Source
IP6 is associated with dietary fiber and thus is naturally present in a wide variety of plant foods, especially wheat bran, whole grains and legumes. The average dietary intake ranges from 1-1.5gm of phytate per day.


Inositol is a B-vitamin and its derivative, IP6 is a natural component of some grain and legumes, particularly soybeans. We naturally can increase our intake of IP6 by consuming the outer layer of grains (rice, wheat, rye), but soybean seed is the best source with its whole seed (bean) containing up to 26% of IP6.

IP6 is available without prescription in most health food stores. It is supplied in 500mg (½gm) capsules and is made by several manufacturers.

Function; Why it is Recommended
IP6 is a premier antioxidant.


Research has shown that IP6 can help prevent kidney stone formation, complications of diabetes(i.e. cataracts, renal damage), lung fibrosis, fatty liver disease, sickle cell anemia, heart disease, high cholesterol and high triglycerides. It is calcium binding, thus preventing formation of the most common type of kidney stone (calcium oxibate). Its antioxidant and ironbuilding properties inhibit the progression of lung fibrosis in asbestosis.

Although used primarily by the community of Alternative Medical Doctors and some open-minded orthodox oncologists (medical cancer doctors) because it suppresses almost all types of cancer, it has some other fantastic benefits for longevity.

Independently, IP6 regulates the oxygen capacity of our red blood cells; it reduces both cholesterol and trigylcerides, as well as preventing heart damage during a heart attack.

In diabetes cases, it not only improves insulin sensitivity, but also decreases complications.

In preliminary studies, IP6 prevents depression and may work adjunctively in schizophrenia. The all-important function of enhancing of our immune system, by increasing the activity of our natural killer (NK) cells, may make IP6 the 'aspirin' of the future.

Instructions
When IP6 is recommended, the dose is 2-8gm daily, which should be taken on an empty stomach to avoid interaction with dietary proteins. Consider taking supplemental inositol with IP6 because additional unbound inositol multiplies its therapeutic activity.


Specifically, the normal recommend dosage is 1-2gm per day, taken between meals twice a day to avoid its interaction with protein in the diet. For individuals with a high risk of cancer, cardiovascular disease, kidney stones, etc., 2-4gm per day. Finally, to help existing cancer, 5-8gm per day.

Side-Effects
IP6 is "as safe as water". However, caution is advised when using IP6 supplementally for an extended period. Phytate in foods reduces mineral absorption, especially iron. Supplemental phytate (IP6) will further contribute to this potential problem and thus additional mineral supplementation may be required.
 

SunMoonsStars

Senior Member
Messages
159
Yes I agree with the comment on sources. Not using the resource for medical advice. Just posting general info because I was curious and hoping others might be able to share some experiences or more info in relation to CFIDS and if it is helpful in immune modulation.
I do not see it listed on this forum upon a search unless I did not do that search correctly.
 

SOC

Senior Member
Messages
7,849
Yes I agree with the comment on sources. Not using the resource for medical advice. Just posting general info because I was curious and hoping others might be able to share some experiences or more info in relation to CFIDS and if it is helpful in immune modulation.
I do not see it listed on this forum upon a search unless I did not do that search correctly.
Part of the question is whether it's wise to "enhance" your immune system if you don't know exactly what the problem is. If you have autoimmune problems, "enhancing" your immune system might be counter-productive.

That said, if your test results show you have low NK cell function, then IP6 might be beneficial. I'm hearing that top ME/CFS specialists are suggesting inosine or immunovir if you have low NK cell function, rather than IP6. I don't know why.

You'll probably get more hits at PR if you search for inositol.
 

barbc56

Senior Member
Messages
3,657
When I do a Google search, all I get are natural news and alternative sources. That alone makes me suspicious. However, I could be wrong but I need other sources besides this.

I can already see possible problems but would rather check the facts before saying more.

Thanks.

Barb
 

SunMoonsStars

Senior Member
Messages
159
Hi
Yes I searched Inositol too but I will try again.
Yes. I need new testing for NK cell function as its been years but it was a result of 2 and near non existent.
Yes. I agree I need to be getting more testing and more detailed view of immunity. I am have appt for blood draw for tests this next week.
Reason I was looking into this now is I have been battling EBV and when I use Tagamet I have had an immediate change and response and I am looking for some other options that are more natural for the future in the area of Immune stimulation.

Do you have a list of the best immune tests that you can recommend and when I go for my testing I want to go over the list my doctor is going to run as well I want to talk about any others that people get here that have been helpful.

Which have been the most helpful or most run for CFIDS/ME patients.
 

SunMoonsStars

Senior Member
Messages
159
When I do a Google search, all I get are natural news and alternative sources. That alone makes me suspicious. However, I could be wrong but I need other sources besides this.

I do agree. Not much out there.
Jarrows brand of the supplement actually prints on the label it increases NK cells and I was surprised they can do that.
There is a disclaimer of course but still. I don't see claims like that often on a supplement label.
 

SOC

Senior Member
Messages
7,849
Do you have a list of the best immune tests that you can recommend and when I go for my testing I want to go over the list my doctor is going to run as well I want to talk about any others that people get here that have been helpful.

Which have been the most helpful or most run for CFIDS/ME patients.
I'd say it's not clear what are the best immune tests for PWME. Who is ordering your immune tests? Would s/he know what you need based on your symptoms?

My best guess at immune tests would be NK cell number, NK cell activity, lymphocyte counts (CD4, CD8, CD3, and probably others) and possibly immunoglobulins and IgG subsets depending on your history and symptoms. But I'm guessing and could be all wrong. :p I'm just going by what's been abnormal in my family's immune testing. Others may have some better ideas.
 

adreno

PR activist
Messages
4,841
Lots of research for anyone interested. A PubMed search for inositol hexaphosphate gives 3481 hits.

I've tried it and didn't feel much, except increased daytime somnolence.
 

SunMoonsStars

Senior Member
Messages
159
I'd say it's not clear what are the best immune tests for PWME. Who is ordering your immune tests? Would s/he know what you need based on your symptoms?

My best guess at immune tests would be NK cell number, NK cell activity, lymphocyte counts (CD4, CD8, CD3, and probably others) and possibly immunoglobulins and IgG subsets depending on your history and symptoms. But I'm guessing and could be all wrong. :p I'm just going by what's been abnormal in my family's immune testing. Others may have some better ideas.

Thank you for the response. I have a couple doctors but... the one running the tests.. is an integrative oncologist who also treats array of people too with auto immunity / disfunction. He knows every detail about me and has reviewed every test I've ever had in my past too. He is open minded to adding extra tests upon my suggestion at times if it might apply and he was not going to run it initially. I find out next week exact ones he is planning on when I go to his office for the lab work as he draws the blood there.
 

SunMoonsStars

Senior Member
Messages
159
Lots of research for anyone interested. A PubMed search for inositol hexaphosphate gives 3481 hits. I've tried it and didn't feel much, except increased daytime somnolence.

Thanks for the response.
Funny thing is the immune stimulation items make me sleepy during the day too. I wonder why that is. Thing is it has replaced my horrible fatigue so I do not complain about it for now.
 

adreno

PR activist
Messages
4,841
Funny thing is the immune stimulation items make me sleepy during the day too.
I didn't even feel immune stimulation, just tiredness. I am guessing it's the inositol part, as regular inositol has the same effect on me.

If you are looking for immune stimulation, prebiotics like medicinal mushrooms or arabinogalactan are much more powerful.
 

barbc56

Senior Member
Messages
3,657

The only research I could find on PUB MED is by Abulkalam Shamsuddin who is mentioned in the article.

Dr. Abulkalam Shamsuddin, a scientist at the University of Maryland School of medicine has been the pioneer researcher of IP6, beginning his work on the compound in the late 1980
.

This doctor also has a patent on his formula this vitamin. Look at the label .
81+UsUfSmKL._SY679_.jpg


Barb
 

barbc56

Senior Member
Messages
3,657
Here is a rat study and claims IP6 result increases NK cells and shows rates of survival of cancer with IP6.
http://www.wjgnet.com/1007-9327/11/5044.pdf

Unfortunately, rat studies do not always translate to human studies.

IP6 is "as safe as water
.

If this IP6 really has medicinal properties, then it's a drug. ANY drug has side effects.

If I seem to be a little harsh is in one of the articles it said that IP6, cured someone's Cholangiocarcinoma, or cancer of the liver duct. It is not curable except by liver transplant but in most cases by the time it's discovered, it's too late. My best friend died from this last year. She did not use alternative treatment but I have read so many stories where people who have a treatable form of cancer, chose alternative treatments. There have been several cases in the news over the last year.

Barb

ETA

Cholangiocarcinoma is caused by ulcerative colitis, an autoimmune disease. No amount of fiber could have prevented this other than some possible symptom control.
 
Last edited:

barbc56

Senior Member
Messages
3,657
Jarrows brand of the supplement actually prints on the label it increases NK cells and I was surprised they can do that.
There is a disclaimer of course but still. I don't see claims like that often on a supplement label

I only see "Supports Natural Cell Defense*". I'm looking at a picture but it shows front and back. Do you have an older bottle? I don't think the FDA guidelines would allow more than that and may have stopped them from printing that.

I'm just speculating, here. :rolleyes:

Barb
 

barbc56

Senior Member
Messages
3,657
Part of the question is whether it's wise to "enhance" your immune system if you don't know exactly what the problem is. If you have autoimmune problems, "enhancing" your immune system might be counter-productive.

That said, if your test results show you have low NK cell function, then IP6 might be beneficial. I'm hearing that top ME/CFS specialists are suggesting inosine or immunovir if you have low NK cell function, rather than IP6. I don't know why.

You'll probably get more hits at PR if you search for inositol.

Yup, I was looking for IP6.

Thanks!

Barb

ETA I see you weren't replying to me. It still helped, though!