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Brand new research published in the last few weeks reveals important information for people with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Fibromyalgia (FM). The research helps explain why individuals dealing with these complex disorders have poor response to physical activity and poor energy production. The cutting-edge studies offer new insight and tools for supporting these devastating illnesses.
AMPK and Chronic Fatigue Syndrome
The Institute of Medicine recently made national headline news by recommending the renaming of CFS/ME to Systemic Exertion Intolerance Disorder (SEID). Many within this community may be dissatisfied at yet another attempt at a dismal name change and limited parameters with the diagnostic criteria, but researchpublished April 2, 2015 helps explain some of the mechanics of exertion intolerance with CFS/ME.
The ground breaking study is entitled “Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome”. Scientists studied skeletal muscle tissue obtained from muscle biopsies of 10 patients with CFS/ME. The muscle cell samples were placed in cultures and stimulated by small electrical pulses for up to 24 hours to cause the muscle cells to contract. They were then compared to healthy control samples.
The results showed that CFS muscle cell cultures had no increase in AMPK phosphorylation or glucose uptake after several hours of electrical stimulation. The test also showed increased myogenin expression at rest and diminished release of IL6. This lack of AMPK activity equates to poor exercise tolerance. While this is a very small sample, this is the first study ever published on this topic of CFS and AMPK activation. It is also important to note that each culture from CFS patients was identified to have this problem.
Read the rest of the ariticle at --http://www.wellnessresources.com/he...d_in_chronic_fatigue_syndrome_and_fibromyalg/
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