Tricycline for parasites, anyone?

[optimist]

Hi!

I was diagnosed with Blastocystis Hominis parasites, and am now on day two of a Tricycline (http://www.allergyresearchgroup.com/tricycline-90-vegetarian-caps) cure to kill them off.
Has anyone tried them? I have experienced a bit of increased frequency of toilet visits, but no other side effect... I was kind of expecting bad die-off reactions, but so far so good.

I am taking 2 capsule twice a day.

 

[Hip]

Here are some drug protocols used to kill Blastocystis hominis, with their percentage success rates indicated:

This study achieved a 60% eradication rate using an orally-taken triple drug cocktail of:
diloxanide furoate 500 mg x 3 daily
Bactrim DS (trimethoprim 160 mg & sulfamethoxazole 80 mg) x 2 daily
secnidazole 400 mg x 3 daily

This study achieved a 82% eradication rate using an orally-taken triple drug cocktail of: comprising:
secnidazole 400 mg x 3 daily
furazolidone 100 mg x 3 daily
nitazoxanide 500 mg x 2 daily
all taken for 10 days.

This study achieved a 94% eradication rate in children from orally taken:
Saccharomyces boulardii probiotic — one capsule (of 5 million CFU) twice daily
all taken for 10 days.

This study (also here) achieved a 96% eradication rate using two intra-colonic infusions (enemas) of three anti-parasite agents:
nitazoxanide 3 grams
furazolidone 900 mg
secnidazole 3.6 grams

This study achieved a 100% eradication rate using a single intra-colonic infusion of:
nitazoxanide 5 grams
furazolidone 1.5 grams
secnidazole 6 grams
followed by 10 days oral nitazoxanide 500 mg taken twice a day.

This study found that the antibiotic rifaximin 600 mg x 3 daily for 14 days eradicates Blastocystis hominis.

Yakoob et al found garlic 4 grams daily to have a similar efficacy to metronidazole for treating Blastocystis hominis. Note: a 180 mg capsule of allicin (a garlic extract) is equivalent to around 200 grams of garlic.


There are some toxicity concerns with furazolidone though (and to a lesser extent with nitazoxanide). For this reason, I devised my own Blastocystis hominis protocol, which is this:

My Own Blastocystis hominis protocol:
Allicin 180 mg x 2
Nitazoxanide 500 mg (take on full stomach)
Septrin DS (trimethoprim 160 mg + sulfamethoxazole 80 mg)
Saccharomyces boulardii 2 capsules

I took all the above twice daily for 10 days. The advantage of the above protocol is that all the meds are non-toxic, except nitazoxanide (but nitazoxanide is not as toxic as furazolidone).

I reasoned if 1 capsule of Saccharomyces boulardii daily has a 96% eradication rate, then 4 capsules daily in my above protocol will be even better, not to mention the addition of lots of other Blasto-killing meds like allicin, nitazoxanide and Septrin DS into my protocol.



See also: http://www.badbugs.org/Blasto_treating.htm

 

[Hip]

Where did you get test for Blastocystis hominis, by the way? I understand that this gut parasite is hard to detect.

 

[Art Vandelay]

Hi!

I was diagnosed with Blastocystis Hominis parasites, and am now on day two of a Tricycline (http://www.allergyresearchgroup.com/tricycline-90-vegetarian-caps) cure to kill them off.
Has anyone tried them? I have experienced a bit of increased frequency of toilet visits, but no other side effect... I was kind of expecting bad die-off reactions, but so far so good.

I am taking 2 capsule twice a day.

When I had blasto, I tried a similar herbal treatment http://www.bioceuticals.com.au/product/preview/Paracea-Forte While it improved some of my gut symptoms, it unfortunately did not get rid of the parasite and my symptoms worsened once I stopped taking it.

I ended up having to use the triple antibiotic treatment @Hip refers to (which eradicated the blasto on the second attempt).

Best of luck!

 

[optimist]

@Hip: Thanks for those articles! My functional doctor had heard good reports of using it, and it would be sad if it is not working. Then, I will have to try something else. His other option for me was using
these for seven days: Vermox, Metronidazol, Gabbroral. They found it a Genova Diagnostics (https://www.gdx.net/). Apparently my GP had also found it with their standard tests, but to him it was not a problem, so he never told me about it

@Art Vandelay: Thank you for telling. It seems I am up to a strong enemy here...

"We shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills; we shall never surrender!"
- Winston Churchill

 

[Hip]

@optimist

I take it the Genova Diagnostics test you used was one of the following:

https://www.gdx.net/product/parasitology-test-stool
https://www.gdx.net/product/comprehensive-parasitology-test-stool
https://www.gdx.net/product/comprehensive-digestive-stool-analysis-2-cdsa2
https://www.gdx.net/product/comprehensive-digestive-stool-analysis-2-with-parasitology-cdsap

All the above include a parasitology test.

I myself had the last of the four above Genova Diagnostics tests (the Comprehensive Digestive Stool Analysis 2.0 With Parasitology) done, in order to investigate my IBS, and my test results said: "No Ova or Parasites Seen."

However, although these Genova Diagnostics tests require you to submit three stool samples, taken on successive days, I understand from the Badbugs website that individuals may be negative for Blastocystis hominis in their first test (comprising three stool samples), but then come out positive in their next test (comprising another three stool samples).

Because Blasto is hard to detect, it can take a total of 6 stool samples before you find it.



Even if Blastocystis hominis ova or parasites are found in your stool, not all strains of Blasto are pathogenic. This study found that of the four different Blastocystis hominis genotypes (genotypes I, II, III and IV) detected in irritable bowel syndrome (IBS) patients, genotype I was the most pathogenic, while genotype II was not found at all in IBS patients, only in healthy controls, suggesting genotype II is not pathogenic.

 

[optimist]

I think the one I took was the second one actually... but it was incredibly expensive, 4 000 NOK (aprox. 8 NOK = 1 USD).

I think I had 5 jars, 1 the first and second day, and then three the last. But only one seemed to be used for parasites. So, I guess if you take it twice, they'll just examine one of the jars for parasites each time.

My functional doctor says that when I am done with the cure I will have to take stool samples twice, two weeks apart, which sounds to be built on the reasons you present here.

Anyways, they did find B.h. both of the last two times I had stool samples, so it seemes that these two laboratories are good at detecting them, or that I have so many that they can't hide... nevertheless, the Genova report said I had few, but then again that only says so much. Who knows how many are living and thriving in the gut...

Interesting about the strains. My report did not specify what genotype they were, but I know that I have severe gut issues for sure...

 

[optimist]

I have now done 3 days with metronidazol 1gx2 and 10 days with Paromomycin 500mgx2.

Hope that it will have the desired effect this time. I am also almost halfway on a Rifaximin 400mgx4 for 10 days for SIBO. So far so good. My gut is getting less leaky