Does anyone care for comparing MAO-A SNPs?

[Gondwanaland]

With so many versions differing from my husband's I hope I am not the only one from us two who ended up with the wrong base.

SNP versions me -- DH
rs72382423 II -- I
rs5906883 A or C CC -- A
rs1465108 A or G GG -- A
rs72373490 II I
rs909525 C or T TT -- C
rs3027397 A or G GG -- A
rs2283724 A or G AA -- G
rs2179098 A or G GG -- G
rs1800464 A or C AA -- A
rs1800659 A or G AA -- G
rs58524323 A or G GG -- G
rs6323 G or T TT -- G
rs1799835 G or T TT -- T
rs3027399 C or G GG -- G
rs2235186 A or G GG -- A
rs2235185 A or G GG -- A
rs2072743 C or T CC -- T
i5900065 G or T GG -- G
rs979605 A or G GG -- A
rs5905418 A or G AA -- A
rs1803986 G or T GG -- G
rs1137070 C or T CC -- T
rs1800466 A or G AA -- A
rs3027407 A or G GG -- A

Anyway, I decided to try a low tyramine diet

EDIT -- Click here for seeing your own MAOA SNPs.
Edit 2 -- For reference the SNP reported by Genetic Genie and Sterling is MAO-A rs6323, being the G alelle (-/-) accounted for faster degradation of serotonin, dopamine, epineprine, and norepinephrine.

 

[drob31]

MAOA 43516479 rs72382423
I

MAOA 43526943 rs5906883 A or C
C

MAOA 43538209 rs1465108 A or G
G

MAOA 43551260 rs72373490
I

MAOA 43553202 rs909525 C or T
T

MAOA 43557081 rs3027397 A or G
G

MAOA 43559576 rs2283724 A or G
A

MAOA 43565635 rs2179098 A or G
G

MAOA 43571197 rs1800464 A or C
A

MAOA 43574169 rs1800659 A or G
A

MAOA 43587431 rs58524323 A or G
G

MAOA 43591036 rs6323 G or T
T

MAOA 43591085 rs1799835 G or T
T

MAOA 43592722 rs3027399 C or G
G

MAOA 43595428 rs2235186 A or G
G

MAOA 43595743 rs2235185 A or G
G

MAOA 43599521 rs2072743 C or T
C

MAOA 43599964 i5900065 G or T
G

MAOA 43601363 rs979605 A or G
G

MAOA 43602965 rs5905418 A or G
A

MAOA 43603113 rs1803986 G or T
G

MAOA 43603391 rs1137070 C or T
C

MAOA 43603735 rs1800466 A or G
A

MAOA 43604841 rs3027407 A or G
no call

 

[ahmo]

Please...tell me you can make something meaningful from this...48 of them...

So what's the difference between low tyramine and low histamine??

MAOA 43516479 rs72382423 II
MAOA 43517364 rs3788862 A or G GG
MAOA 43518188 rs5905702 G or T GG
MAOA 43519176 rs6520893 A or G AA
MAOA 43526548 rs6520894 G or T TT
MAOA 43526943 rs5906883 A or C CC
MAOA 43527624 rs5906893 C or T TT
MAOA 43535927 rs7882699 A or G GG
MAOA 43538209 rs1465108 A or G GG
MAOA 43540295 rs5906938 A or G GG
MAOA 43544506 rs12688067 C or T TT
MAOA 43547310 rs5906957 A or G GG
MAOA 43551260 rs72373490 II
MAOA 43552477 i5900171 A or C CC
MAOA 43553202 rs909525 C or T TT
MAOA 43554672 rs3027396 C or T TT
MAOA 43555564 rs6520897 A or C CC
MAOA 43557081 rs3027397 A or G GG
MAOA 43559576 rs2283724 A or G AA
MAOA 43559976 rs2283725 A or G GG
MAOA 43560273 rs2283726 A or G AA
MAOA 43565635 rs2179098 A or G GG
MAOA 43567173 rs28375424 C or T CC
MAOA 43568861 rs9330645 A or G GG
MAOA 43570824 rs12833929 A or G GG
MAOA 43571197 rs1800464 A or C AA
MAOA 43573666 rs12843268 A or G GG
MAOA 43574169 rs1800659 A or G AA
MAOA 43575061 rs28439389 A or G GG
MAOA 43580860 rs28556796 A or G GG
MAOA 43587431 rs58524323 A or G GG
MAOA 43587868 rs3810709 C or T TT
MAOA 43588010 rs6610845 C or T TT
MAOA 43591036 rs6323 G or T TT
MAOA 43591085 rs1799835 G or T TT
MAOA 43592016 rs1800465 A or T AA
MAOA 43592763 rs3027400 G or T GG
MAOA 43593479 rs12689575 A or G GG
MAOA 43595428 rs2235186 A or G GG
MAOA 43595678 rs3027403 C or T CC
MAOA 43599521 rs2072743 C or T CC
MAOA 43599964 i5900065 G or T GG
MAOA 43599982 rs7065428 A or G AA
MAOA 43601363 rs979605 A or G GG
MAOA 43603113 rs1803986 G or T GG
MAOA 43603391 rs1137070 C or T CC
MAOA 43603735 rs1800466 A or G AA
MAOA 43604841 rs3027407 A or G GG

 

[PeterPositive]

It's easier for me to paste from the raw data, the html table results badly formatted here.
Does this help?

rs72382423  X   43516479    I
rs3788862   X   43517364    G
rs5905702   X   43518188    G
rs6520893   X   43519176    A
rs6520894   X   43526548    T
rs5906883   X   43526943    C
rs5906893   X   43527624    T
rs7882699   X   43535927    G
rs1465108   X   43538209    G
rs5906938   X   43540295    G
rs12688067  X   43544506    T
rs5906957   X   43547310    G
rs72373490  X   43551260    I
i5900171    X   43552477    C
rs909525    X   43553202    T
rs3027396   X   43554672    T
rs6520897   X   43555564    C
rs3027397   X   43557081    G
rs2283724   X   43559576    A
rs2283725   X   43559976    G
rs2283726   X   43560273    A
rs2179098   X   43565635    G
rs28375424  X   43567173    C
rs9330645   X   43568861    G
rs12833929  X   43570824    G
rs1800464   X   43571197    A
rs12843268  X   43573666    G
rs1800659   X   43574169    A
rs28439389  X   43575061    G
rs28556796  X   43580860    G
rs58524323  X   43587431    G
rs3810709   X   43587868    T
rs6610845   X   43588010    T
rs6323  X   43591036    T
rs1799835   X   43591085    T
rs1800465   X   43592016    A
rs3027400   X   43592763    G
rs12689575  X   43593479    G
rs2235186   X   43595428    G
rs3027403   X   43595678    --
rs2072743   X   43599521    C
i5900065    X   43599964    G
rs7065428   X   43599982    A
rs979605    X   43601363    G
rs1803986   X   43603113    G
rs1137070   X   43603391    C
rs1800466   X   43603735    A
rs3027407   X   43604841    --

 

[pogoman]

43516479 rs72382423
I
43526943 rs5906883 A or C
A
43538209 rs1465108 A or G
A
43551260 rs72373490
I
43553202 rs909525 C or T
C
43557081 rs3027397 A or G
A
43559576 rs2283724 A or G
G
43565635 rs2179098 A or G
G
43571197 rs1800464 A or C
A
43574169 rs1800659 A or G
G
43587431 rs58524323 A or G
G
43591036 rs6323 G or T
G
43591085 rs1799835 G or T
T
43592722 rs3027399 C or G
G
43595428 rs2235186 A or G
A
43595743 rs2235185 A or G
A
43599521 rs2072743 C or T
T
43599964 i5900065 G or T
G
43601363 rs979605 A or G
A
43602965 rs5905418 A or G
A
43603113 rs1803986 G or T
G
43603391 rs1137070 C or T
T
43603735 rs1800466 A or G
A
43604841 rs3027407 A or G
A

 

[ebethc]

@Gondwanaland - here are my results...

What's the diff between MAO-a vs. MAO-b?

Didn't you say quercetin is a MAO inhibitor? is that a good thing or a bad thing?

 

[Gondwanaland]

Thanks, folks, I have been compiling a spreadsheet, but the fact that some people have double as much os SNPs tested by 23andMe is making this too much work.

What's the diff between MAO-a vs. MAO-b?

From: http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=1791

In humans there are two types of MAO: MAO-A and MAO-B.[5]

• Both are found in neurons and astroglia.
• Outside the central nervous system:
  • MAO-A is also found in the liver, pulmonary vascular endothelium, gastrointestinal tract, andplacenta.
  • MAO-B is mostly found in blood platelets.

Function
Norepinephrine degradation. Monoamine oxidase is shown left in the blue box.[6]
Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia.

Monoamine oxidases contain the covalently bound cofactor FAD *** and are, thus, classified as flavoproteins ***.

Substrate specificities
They are well known enzymes in pharmacology, since they are the substrate for the action of a number of monoamine oxidase inhibitor drugs. MAO-A is particularly important in the catabolism of monoamines ingested in food. Both MAOs are also vital to the inactivation of monoaminergic neurotransmitters, for which they display different specificities.

• Serotonin, melatonin, noradrenaline, and adrenaline are mainly broken down by MAO-A.
• Phenethylamine and benzylamine are mainly broken down by MAO-B.
• Both forms break down dopamine, tyramine, and tryptamine equally.[7]

Specific reactions catalyzed by MAO include:

• Adrenaline or noradrenaline to 3,4-Dihydroxymandelic acid
• Metanephrine or normetanephrine to vanillylmandelic acid (VMA)
• Dopamine to dihydroxyphenylacetic acid
• 3-Methoxytyramine to homovanillic acid

From: http://en.wikipedia.org/wiki/Monoamine_oxidase
*** here is why vit B2 supplementation is recommended (as per @Sherpa ). I think I didn't tolerate it in the past because I had a downregulation in serotonin production (see below).

Didn't you say quercetin is a MAO inhibitor? is that a good thing or a bad thing?

It is a good thing if it makes you feel better, and a bad thing if it makes you feel worse

In my understanding there are 2 main situations involved here:

• the serotonin you produce is too much for your enzymes to break down and you get serotonin syndrome symptoms such as anxiety, breathlessness etc
• this leads to a down regulation in the serotonin production, and you end up with too little serotonin and depression symptoms

I have been reading with interest Ray Peat's ideas about serotonin being a poison

 

[ebethc]

In my understanding there are 2 main situations involved here:

• the serotonin you produce is too much for your enzymes to break down and you get serotonin syndrome symptoms such as anxiety, breathlessness etc
• this leads to a down regulation in the serotonin production, and you end up with too little serotonin and depression symptoms

thanks. Quercetin really helps me (MAO inhibitor - though not sure if it's MAO a or b or both). Not sure if I have too much or too little, because I have terrible brain fog (too little? hard to say because brain fog can be caused by SO many things) and I do get too anxious.... When I was reading about genetics a lot, I felt that there was some difficulty breaking things down... (ie, neurotransmitters & estrogen, as I recall... but I don't remember which snp/snps)

 

[Gondwanaland]

@ebethc I find it difficult to figure out too!