andre79
Senior Member
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- 122
Hello!
I know there are hundreds of posts that explain methylation, but I don't have the energy or the brain clarity at this moment to read all of them, since I am doing an extra effort and focusing all my energy in the post-grade course I just started and working on line.
So, i found this protocol (Dr. Myhills) which seems very simple to start with the methylation:
http://www.drmyhill.co.uk/wiki/CFS_-_The_Methylation_Cycle
Anyway, I have taken a Vitamin B supplement but I think these are the active forms of the vitamins which should be better. In the country where I live at the moment, i have no access to any genetic testing to see if i have gene mutations, so it would be more like a trial and error matter.
I have read for many people here that they have gotten better with methylation. Please notice that i have a liver issue so i wonder how the protocol could affect me, good or bad. Please give me your opinion.
Thanks again
I know there are hundreds of posts that explain methylation, but I don't have the energy or the brain clarity at this moment to read all of them, since I am doing an extra effort and focusing all my energy in the post-grade course I just started and working on line.
So, i found this protocol (Dr. Myhills) which seems very simple to start with the methylation:
The Methylation Cycle - which supplements to take to support
This is the package of supplements to support the methylation cycle. It needs to be taken in addition to everything else, i.e. the standard nutritional package (multivits, multiminerals, EFAs, vits C + D) and the mitochondrial rescue package (D-ribose, acetyl-L-carnitine, CoQ10, etc.)! But the methylation package will change with time because as the methylation cycle starts to work again, it will start to stand on its own feet. Everyone”s package will be a bit different depending on how poorly their cycle is working. One day we will have the biochemical tests to tailor make each package for each person, but until then I suggest the following regime for those sufferers who have been taking vitamin B12 in oral form (as either hydroxocobalamin or cyanocobalamin):
For two months a daily dose of
If you are better - fine! If you are worse - it may be the reaction to the methylation package because it may cause an acute detox reaction (see below). Slow down the regime - take smaller amounts of the supplements and build up slowly. If you are unchanged - swap the sublingual B12 for injected B12 ie:
- Methylcobalamin 1 mg sublingually
- Methyltetrahydrofolate 800mcg (ActiFolate)
- Pyridoxal-5-phosphate 100mgs (50mgs twice daily)
- Glutathione 250mgs daily
- Phosphatidyl Serine 200mgs (100mgs twice daily) - BioCare
If you are better - fine! If you are worse - it may be the reaction. If you are unchanged, add in:
- Daily subcutaneous injections methylcobalamin 0.5mgs (this is a bit more expensive than cyanocobalamin). Some CFSs will not respond clincially until 5mgs daily is injected. B12 is very safe with no known toxicity- as a collegue commented - the only way you could kill yourself with B12 would be to drown in the stuff! I would prefer people to start with this regime but I know many do not fancy the idea of injections - actually I am a wimp too, but they are easy and almost painless.
- Methyltetrahydrofolate 800mcg (ActiFolate)
- Pyridoxal-5- phosphate 100mgs (50mgs twice daily)
- Glutathione 250mgs daily
- Phosphatidyl Serine 200mgs (100mgs twice daily) - BioCare
For those sufferers who have already tried B12 by injection as either hydroxocobalamin or cyanocobalamin before starting the methylation cycle protocol, go straight on to injections of methylcobalamin.
- Tri-methylglycine or TMG (not to be confused with betaine hydrochloride, so always ensure that you are taking pure-grade TMG)
- Lecithin (phosphatidyl choline) and Phosphatidyl Ethanolamine.
- S-adenosyl methionine (SAMe) directly as a supplement 400mgs daily
http://www.drmyhill.co.uk/wiki/CFS_-_The_Methylation_Cycle
Anyway, I have taken a Vitamin B supplement but I think these are the active forms of the vitamins which should be better. In the country where I live at the moment, i have no access to any genetic testing to see if i have gene mutations, so it would be more like a trial and error matter.
I have read for many people here that they have gotten better with methylation. Please notice that i have a liver issue so i wonder how the protocol could affect me, good or bad. Please give me your opinion.
Thanks again
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