This came up in a thread on q10 supplement study on GWS veterans, where it was found to have positive effects at 100mg and negative or no effects at 300mg.
The authors noted that Dose Consideration was:
"Nonmonotonic.
This is the norm for antioxidants: many are prooxidant at higher doses. BUT point of transition varies.
This is common for nutrients: Supplement trials often err by thinking if some is good, more is
better" and quote this study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393521/
The authors noted that Dose Consideration was:
"Nonmonotonic.
This is the norm for antioxidants: many are prooxidant at higher doses. BUT point of transition varies.
This is common for nutrients: Supplement trials often err by thinking if some is good, more is
better" and quote this study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393521/