Ema
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I understand that there are two pathways that LDN can work by - either by blocking the opioid receptor or through the TLR4 pathway.
As far as dosing LDN, I've also read that dosing once a day is best for increasing the endorphin levels through the rebound effect but that dosing twice a day (or more) may be more helpful for reducing the overall inflammation through the TLR4 pathway. It seems like this might be the more useful method in ME/CFS if indeed LDN works by inhibiting the microglia more than through the endorphin boost.
I wonder if there is anyone out there that has experimented with dosing LDN twice a day versus the more commonly suggested once a day plan?
Thanks!
Ema
As far as dosing LDN, I've also read that dosing once a day is best for increasing the endorphin levels through the rebound effect but that dosing twice a day (or more) may be more helpful for reducing the overall inflammation through the TLR4 pathway. It seems like this might be the more useful method in ME/CFS if indeed LDN works by inhibiting the microglia more than through the endorphin boost.
I wonder if there is anyone out there that has experimented with dosing LDN twice a day versus the more commonly suggested once a day plan?
Thanks!
Ema
LDN’s microglial inhibiting properties have not received a great deal of study. Studies suggest, though, that LDN is able to suppress microglia activation by suppressing receptors (TLR4) which play key role in the production of nerve pain. (Interestingly these same receptors may be responsible for opioid induced pain sensitivity and reduced opioid effectiveness).
Read more: Microglial Inhibiting Drugs – Providing Hope for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)? http://www.cortjohnson.org/blog/201...-fibromyalgia-chronic-fatigue-syndrome-mecfs/