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MS as is persistent low ferritin and low D3 levels.
Hi Justy,
I hope you will get all the help you need from KDM, but just some comments on the lab values that I am familiar with.
Your TSH indicates a low thyroid but should first be completed with free T3 and free T4. And test for antibodies. Often a lowered body temperature correlates with a low thyroid. www.stopthethyroidmadness.com has a lot of good information.
An iron deficiency might have an impact on the function of the thyroid. According to two thyroid doctors the ferritin should be high in reference range.
A B12 deficiency might cause an iron deficiency. Quoting a doctor: "without enough B12 the iron will not stay". What about other markers for B12 deficiency as homocystein and methyl malonic acid?
With a low thyroid, iron and eventually B12 (and folate) you are also more prone to infections and an impaired immune system.
Good to see some treatable issues among the others that I don´t know enough about. Best of luck, Justy!
So I have my results back and have hurt my brain trying to understand them all - but as there is not too much that is out of range it hasn't been too hard.
I will just post the results that were out of range, with the reference ranges if applicable.
food intolerance panel - only chicken egg showed a strong reaction. With wheat, gluten, rye and mushrooms showing a slight but very low reaction.
Bartonella henselae IgG marked as 1/64 in red (meaning positive), but then says: meaning of low titres is unknown.Aspecific reactions are possible. Then underneath it says Bartonella - negative.
I also have another remark on Yersinia which says: see enclosed immunoblot report. The report makes no sense to me - a reference strip and patient strip with bands that I cant read or understand, except the report has the word negative on it.
Chlamydia serology - Chlamydia pneumonia IgG POSITIVE. IgA NEGATIVE. I'm not sure if this means I have CPn or not - would fit with my symptoms and I have had pneumonia twice in the past 6 years. The report also has a band with reference ranges, but again I don't understand how to read it, but it says Cpn = pos. 18P.
Perforin mRNA expression = 1300 reference range listed as 250,00 - 750,00 (I though the ref range was in the thousands and my perforin was low, but my husband says the way they do it in Europe is that the 250,00 is 250 -750 and therefore my perforin is HIGH - which I think means my NK cell activity is actually high, not low as seen in M.E)
Prostaglandine E2 = 17.46 reference range 0.10 - 2.81 HIGH (inflammatory? highly correlated with brain inflammation?)
Soluble CD 14 = 3908 reference range 1430,00 - 2800,00 HIGH not sure what this means?
NAGA (I presume nagalese) DPP4 Adult = 18.39 reference range 18.80 - 33.79 SLIGHTLY LOW. All other Naga normal.
CYTS (cytokines?) all normal except IL-8 Serum = 2394 reference range 0.00 - 15.00 HIGH
T cells, B cells, NK Cells screening all listed as normal.
Haemoglobin = 11.6 reference range 12.0 - 16.0 Iron levels LOW again!
MCV LOW = 81 " " 82 - 98
MCH LOW = 26 " " 27 - 34
Antinuclear Factor = 80 reference range 0 - 40 Antinuclear antibodies detected in a speckled pattern
Ferritin = 7 reference range 12 - 125 LOW again!
Vitamin D3 25 OH = 10.6 reference range 20.0 - 43.0 LOW.
TSH marked as in range, but it's at 3.42, which I think is quite high.
Stool test shows a low diversity index of 3.00 with Dysbiosis associated with low diversity.
Also a low Firmicutes versus Bacteroidetes ratio which may be associated with gut inflammation.
The biggest shock has been seeing the ANA result - especially as I have wondered for years if I may in fact have something like Lupus, rather than M.E. KDM did test me for VDRL which many Lupus patients have a false positive to and mine was negative, so I guess he was considering Lupus - although it doesn't have to be positive . It seems to me as well that my immune system is inf act ramped up, rather than down, which fits with the autoimmune hypothesis.
I looked at the Lupus criteria today again and you need 4 for a diagnosis and I now have 7 Cpn is also commonly found in Lupus and MS as is persistent low ferritin and low D3 levels. I will be asking KDM what he thinks about this when I have my phone consult in a couple of weeks.
It may also explain why I no longer seem to catch colds, flu etc, whereas years ago I was non stop catching things.
I would be very interested to hear what others think about my test results - I don't seem to have the typical 'M.E' pattern I don't think...
All the best
Justy.
@justy So does having low thyroid function cause iron and B12 deficiency? I read on stop the madness that low thyroid decreases stomach acid production.
@justy do you take vitamin D3 at all?
Justy,So I have my results back and have hurt my brain trying to understand them all - but as there is not too much that is out of range it hasn't been too hard.
I will just post the results that were out of range, with the reference ranges if applicable.
food intolerance panel - only chicken egg showed a strong reaction. With wheat, gluten, rye and mushrooms showing a slight but very low reaction.
Bartonella henselae IgG marked as 1/64 in red (meaning positive), but then says: meaning of low titres is unknown.Aspecific reactions are possible. Then underneath it says Bartonella - negative.
I also have another remark on Yersinia which says: see enclosed immunoblot report. The report makes no sense to me - a reference strip and patient strip with bands that I cant read or understand, except the report has the word negative on it.
Chlamydia serology - Chlamydia pneumonia IgG POSITIVE. IgA NEGATIVE. I'm not sure if this means I have CPn or not - would fit with my symptoms and I have had pneumonia twice in the past 6 years. The report also has a band with reference ranges, but again I don't understand how to read it, but it says Cpn = pos. 18P.
Perforin mRNA expression = 1300 reference range listed as 250,00 - 750,00 (I though the ref range was in the thousands and my perforin was low, but my husband says the way they do it in Europe is that the 250,00 is 250 -750 and therefore my perforin is HIGH - which I think means my NK cell activity is actually high, not low as seen in M.E)
Prostaglandine E2 = 17.46 reference range 0.10 - 2.81 HIGH (inflammatory? highly correlated with brain inflammation?)
Soluble CD 14 = 3908 reference range 1430,00 - 2800,00 HIGH not sure what this means?
NAGA (I presume nagalese) DPP4 Adult = 18.39 reference range 18.80 - 33.79 SLIGHTLY LOW. All other Naga normal.
CYTS (cytokines?) all normal except IL-8 Serum = 2394 reference range 0.00 - 15.00 HIGH
T cells, B cells, NK Cells screening all listed as normal.
Haemoglobin = 11.6 reference range 12.0 - 16.0 Iron levels LOW again!
MCV LOW = 81 " " 82 - 98
MCH LOW = 26 " " 27 - 34
Antinuclear Factor = 80 reference range 0 - 40 Antinuclear antibodies detected in a speckled pattern
Ferritin = 7 reference range 12 - 125 LOW again!
Vitamin D3 25 OH = 10.6 reference range 20.0 - 43.0 LOW.
TSH marked as in range, but it's at 3.42, which I think is quite high.
Stool test shows a low diversity index of 3.00 with Dysbiosis associated with low diversity.
Also a low Firmicutes versus Bacteroidetes ratio which may be associated with gut inflammation.
The biggest shock has been seeing the ANA result - especially as I have wondered for years if I may in fact have something like Lupus, rather than M.E. KDM did test me for VDRL which many Lupus patients have a false positive to and mine was negative, so I guess he was considering Lupus - although it doesn't have to be positive . It seems to me as well that my immune system is inf act ramped up, rather than down, which fits with the autoimmune hypothesis.
I looked at the Lupus criteria today again and you need 4 for a diagnosis and I now have 7 Cpn is also commonly found in Lupus and MS as is persistent low ferritin and low D3 levels. I will be asking KDM what he thinks about this when I have my phone consult in a couple of weeks.
It may also explain why I no longer seem to catch colds, flu etc, whereas years ago I was non stop catching things.
I would be very interested to hear what others think about my test results - I don't seem to have the typical 'M.E' pattern I don't think...
All the best
Justy.
Im just a newbie and maybe someone else already said it:
guess was yasko saying sometime that low ferritin is from chronic infections usually bacterial.
maybe this should be your target - identifying pathogens ...my two cents.
I also have Yersinia identified but also much more pathogens including Hpylori.
any stool sample? gram negative bacteria?