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Results pretty good (?) apart from missing GSTT1 and red flag on CBS A360A

ukxmrv

Senior Member
Messages
4,413
Location
London
I finally got around to running my 23andme results through Genetic Genie etc and the only red flags that came up were

GSTT1 Absent

CBS A360A rs1801181 AA

There were a few yellow flags and missing things as well but compared to others here I feel as if I may have got away lightly.

SHMT1 C1420T rs1979277 AG
BHMT-08 rs651852 CT
MTRR A664A rs1802059 AG
MTRR A66G rs1801394 AG
COMT V158M rs4680 AG
COMT H62H rs4633 CT
VDR Bsm rs1544410 CT
VDR Taq rs731236 AG
MAO-A R297R rs6323 GT
ACAT1-02 rs3741049 AG
MTHFR C677T rs1801133 AG

and yellows /missing from detox profile

CYP1B1 R48G rs10012 -- no call
CYP2C9*2 C430T rs1799853 CT
CYP2C19*17 rs12248560 CT
CYP2D6 S486T rs1135840 CG
CYP2D6 2850C>T rs16947 AG
NAT2 R197Q rs1799930 AG


This is anything here that leaps out at anyone? In the past I've tested for low blood folate and low red blood cell glutathione. The NHS prescribed their folic acid treatment that did help with neuropathic type pain and some neurological symptoms but seems to have resulted in an increased inability to tolerate sulfurous veges.

Have tried injections of Cyan B12 in the past with no obvious improvement, various types of folate and supplements around the Meth cycle but not hit on the right combo that improves symptoms.

Anything obvious here?
 
Last edited:
Messages
15,786
@ukxmrv - The CBS +/+ isn't one that can cause problems.

But missing GSTT1 causes problems in detoxing certain substances.

MTHFR C677T being heterozygous also means that enzyme activity is reduced to 65% of normal, which would explain your low folate results. Supplementing methylfolate (not folic acid) may be helpful, since the mutation results in less conversion of folic acid into methylfolate.
 

caledonia

Senior Member
I finally got around to running my 23andme results through Genetic Genie etc and the only red flags that came up were

GSTT1 Absent

CBS A360A rs1801181 AA

There were a few yellow flags and missing things as well but compared to other here I feel as if I may have got away lightly.

SHMT1 C1420T rs1979277 AG
BHMT-08 rs651852 CT
MTRR A664A rs1802059 AG
MTRR A66G rs1801394 AG
COMT V158M rs4680 AG
COMT H62H rs4633 CT
VDR Bsm rs1544410 CT
VDR Taq rs731236 AG
MAO-A R297R rs6323 GT
ACAT1-02 rs3741049 AG
MTHFR C677T rs1801133 AG

and yellows /missing from detox profile

CYP1B1 R48G rs10012 -- no call
CYP2C9*2 C430T rs1799853 CT
CYP2C19*17 rs12248560 CT
CYP2D6 S486T rs1135840 CG
CYP2D6 2850C>T rs16947 AG
NAT2 R197Q rs1799930 AG


This is anything here that leaps out at anyone? In the past I've tested for low blood folate and low red blood cell glutathione. The NHS prescribed their folic acid treatment that did help with neuropathic type pain and some neurological symptoms but seems to have resulted in an increased inability to tolerate sulfurous veges.

Have tried injections of Cyan B12 in the past with no obvious improvement, various types of folate and supplements around the Meth cycle but not hit on the right combo that improves symptoms.

Anything obvious here?

All those yellows (+/-) can add up and still make you sick depending on environmental exposures. In fact, all of my SNPs except for one detox SNP are yellows. I just have a whole lot of them.

You're taking synthetic folate and B12. Those are not going to be effective for your SNPs. Methylfolate is preferred for MTHFR. For your MTRRs (B12 recycling) you would need B12. Your COMT/VDR taq combo determines the type of B12. For you, Yasko suggests hydroxycobalamin and adenosylcobalamin. Taking methylcobalamin could cause an overdose of methyl groups, and thus mood swings. So it would be best to avoid that. B12 needs to be taken either sublingually or by injection, as it doesn't absorb well in the stomach.

Read these two documents in my signature links for more info - Roadblocks to Successful Methylation and Start Low And Go Slow.