Detox (I'm only including Homozygous because Hetero are way too many to list)
PON1 Q192R rs622 ++ CC
Methylation
Homozygous
CBS A360A rs1801181 ++ AA
MTHFR A1298C ++ GG
Heterozygous
BHMT - all those listed on MTHFRSupport report
COMT V158M rs4680 +-
MAO A R297R +-
MTR A2756G +-
MTRR A66G +-
MTRR H595Y +-
MTRR K350A +-
MTRR rs10520873
MTRR rs9332
SMHT2 rs34095989 +-
(I'm assuming this is actually SHMT~Caledonia)
VDR Bsm +-
VDR Taq +- (I looked this one up in my raw data)
Here's my analysis. I erased the ones I'm not as familiar with or which are not significant. I don't like the MTHFRsupport SNP analysis because, for the most part, they don't have treatments for all the SNPs they've come up with. They might become more significant later if they can come up with treatments.
And as you're saying, so many SNPs are confusing. You can make quite a lot of progress on just methylation SNPs.
So that being said, here goes:
You have two First Priority mutations which you need to take care of before you get into taking methyl supplements. For SHMT take folinic acid. SHMT is also one of the "leaky gut genes". You should check for leaky gut and if positive, treat with a 4R gut rebuilding program before proceeding. One risk factor is antibiotics. Symptoms are things like multiple food intolerances. You can do an intestinal permeability test, or a stool test to see what gut bugs and imbalances you have and treat for those.
The next one is CBS. The A360A is the minor one, which generally doesn't seem to need treatment, but you're +/+ and you have all the BHMTs which add to CBS. If ammonia and sulfur are high on testing, or you react to sulfur foods, or you start having a stress/anxiety reaction when you start methyl supps, you'll need to treat CBS. Heartfixer is a good reference for what to do.
Then the Second Priority Mutations - for the BHMTs, take TMG. BHMT is the secondary backup methylation pathway.
You have MTR and all the MTRRs. This is a double whammy on B12. MTR blocks B12 as it comes in from the diet. MTRR blocks recycling of B12 after it's been through the cycle. So you'll definitely need B12 supplementation. Yasko suggests checking lithium levels and supplementing if low before doing B12.
The COMT/VDR combo affects what kind of B12 you can tolerate. Yasko has a nice chart in her Simplified Roadmap. For your combination, Yasko suggests hydroxycobalamin and adenosylcobalamin, to avoid mood swings.
For MTHFR A1298C, some methylfolate.
PON1 detoxifies pesticides and nerve gas, so avoid those, and eat your fruits and veggies.
Leave MAO A until last. Maybe some 5htp for that. But that's contraindicated if you're on an SSRI or SNRI.
See the links in my signature for more info.
