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Wendi C
Yes, I think Dr. Ben mentioned that increased methylation without proper balancing can lead to elevated methionine, and subsequent SAM levels. Especially those prone to not properly converting vitamin b6 which is necessary for proper conversion into taurine, cysteine, sulfate, and glutathione.
He mentioned supplementing P5P, and Magnesium to protect against neuronal damage, alongside niacin for soaking up excess methyl groups from methyl folate.
this is all interesting stuff to read about and makes sense, if one of the essential co factors is deficient then where does the excess production go? I guess in the study cited it is suggested that the effects of methylation can turn neuronal toxic at high enough doses without proper co vitamin dependencies like b6, choline, magnesium, etc..
Ahh it all just makes me head hurt though and feels conflicting, I just wish I could use a simple protocol and stick to it without having to do so much research and watching out for so many side effects and the like...
I really wonder what Fred's take is on this. I found his protocol to be the most efficient but even then if someone is having issues like excess methionine production without proper carrier vitamins for conversion this can be a problem. At least until everything is balanced and equilibrium is established.
I guess it is pretty essential for anyone using any type of methylation protocol to get tested and find what possible mutations they may be dealing with. We all can't just supplement the same things like supplemental SAM E and expect the same results, like someone may severly low in methionine and this would help to get nutrients into cells, but for those with excessive methionine this could become toxic.
I feel as if Fred's protocol is very potent and the essential co factors are necessary for proper methylation, these seemingly already being in harmony and not necessary to decide to use folic, folinic, or whatever synthetic form over bio active Folate, as well as Methyl b12, and Adeno b12 already being set as perfect harmonizers. It seems the issue is more related to the other range of b vitamins, magnesium, calcium, and other potential methyl donors found through diet or supplementation. There are also no toxic ranges of the nutrients in the protocol, however it seems we do have to be aware of other potential issues like depleted necessary co factors enzymes, vitamins, minerals, etc.. Definitely confirming our own genetic testing results for a better indication of what may be better for each individual.