Here is my 23and me results mthylation and detox can you give advices?

[joshi81]

hi finally got 23and me results..but now? someone can enlight me?

 

[Helen]

What did they say about your GSTT1 SNP? It is important for your ability to conjugate/bind with glutathione.

 

[joshi81]

GSTT1 is normal
GTSM1 is absent (i do not have the gene)
GSTP1 is Heterozigote

 

[joshi81]

@caledonia @Critterina @Valentijn could you give an opinion? thanks

 

[Valentijn]

@caledonia @Critterina @Valentijn could you give an opinion? thanks

I don't see anything in the methylation part which is likely to be problematic. I don't know about the detox SNPs.

 

[Helen]

The MTHFR 1298 polymorphism might have an impact on your folate metabolism and the MTRR A66G polymorphismn might have an impact on the vitamin B12 metabolism. Together they might decrease your methylation capacity. (I write might as we never know the outcome of gene defects without further testing). The many COMT polymorphisms probably decreases your ability to break down neurotransmittors as it decreases your ability to handle methyl donors. You might well tolerate methylcobalamin though. A trial will tell. Adrenalin that doesn´t break down normally is also a common problem. Maybe you have some experience of that.

Other polymorphisms may also cause decreased methylation, but without a Methylation Pathway Panel or some of its labvalues, it is impossible to tell the state. Intolerance for alcohol might be an indication. A methylation protocol as a trial if you don´t want to do the tests will hopefully show your needs.

By now on the forum, you surely know that an important end product from methylation is glutathione. The body´s strongest antioxidant.
With polymophisms in the GST genes you will though have a decreased ability to "make use of" the glutathione. That means you can´t bind toxins to the (already low) glutathione properly without enough GST enzymes.

The GSTM1 deletion is connected to a decreased detoxification as it is absent. And so is probably the GSTP1 polymorphism. Also the CYP2D6 is said to have a negative impact. If you have amalgam fillings or if you are exposed to other toxins (e.g. molds or pesticides) that might cause your symptoms. I don´t know about your diagnose(s) or symptoms but you will surely find out more about possible connections. Don´t remove any amalgam, if you have fillings, before studying safe removal. In short: avoid toxins of any kind, and try to support both methylation and the GST enzymes. Hope this was of some help. This is only a short version of your polymorphisms that might have an impact on your health. This sample from a gene test gives good answers according to a specialist in genetics. Compare your results and the recommendations
http://www.gdx.net/core/sample-reports/Detoxi-Genomics-Sample-Report.pdf

 

[joshi81]

Thanks Valentijn and helen.
@Helen what do you mean by saying that "Adrenalin that doesn´t break down normally is also a common problem. Maybe you have some experience of that"
What symptoms does it cause?
At the moment my problems are pretty neuromuscular: twitching, widespread muscle soreness/fatigued, breathlessness, sensation of pulling muscles in neck, legs
I know i have low homocysteine (who knows maybe due to cbs mutation??) it was a little bit under the normal range.

 

[Valentijn]

Thanks Valentijn and helen.
@Helen what do you mean by saying that "Adrenalin that doesn´t break down normally is also a common problem. Maybe you have some experience of that"
What symptoms does it cause?
At the moment my problems are pretty neuromuscular: twitching, widespread muscle soreness/fatigued, breathlessness, sensation of pulling muscles in neck, legs
I know i have low homocysteine (who knows maybe due to cbs mutation??) it was a little bit under the normal range.

There's no reason whatsoever to think that slower COMT is a problem, especially when neurotransmitter formation (as indicated by MAOA) is also slow. It is extremely common and perfectly normal.

Magnesium can help with the twitching, as well as respecting the limitations of your muscles.

 

[Helen]

Thanks Valentijn and helen.
@Helen what do you mean by saying that "Adrenalin that doesn´t break down normally is also a common problem. Maybe you have some experience of that"
What symptoms does it cause?
At the moment my problems are pretty neuromuscular: twitching, widespread muscle soreness/fatigued, breathlessness, sensation of pulling muscles in neck, legs
I know i have low homocysteine (who knows maybe due to cbs mutation??) it was a little bit under the normal range.

Sorry I didn´t express myself better. COMT mutations may cause a decreased breakdown of adrenalin. That means that adrenaline stays in your body longer than normal. The most typical symptom is that you can´t calm down after being physically or emotionally upset. Insomnia is common. The only antidote I have found is physical activity. Not easy , or impossible, with ME. There are also medications that contain adrenaline which cause tachycardia as medications for asthma and injectable anesthesia at the dentist to avoid.

Dr. Ben Lynch discusses the possible impact of MTHFR 1298 polymorphism and homocystein here
http://mthfr.net/mthfr-a1298c-mutation-some-information-on-a1298c-mthfr-mutations/2011/11/30/

Lynch:
"I know many doctors evaluate homocysteine only when it comes to MTHFR mutations.
This is absolutely incorrect.
Those with A1298C MTHFR mutations do not display elevated homocysteine unless they are combined with C677T. Even when combined with C677T MTHFR mutations, the A1298C types still do not tend to have very elevated homocysteine."

A B12+folate deficiency , and as Valentinj writes also lack of magnesium , could cause your symptoms. Not to forget the co-factors in methylation. You didn´t mention any amalgam fillings (that would put demand on your methylation too).

@Valentijn I am sorry, but I can´t agree to what you say. I have five out of six polymorphisms in the tested COMT SNP´s and I am also homozygote MAO, and I have the adrenaline problem that I wrote about. Some other people who I know that are gene tested have the same problem. There is also a positive effect described from COMT mutations. People use to be more creative and have a better ability for association than normal. The decreased breakdown of certain transmittors is said to cause this.

 

[joshi81]

thanks @Helen the point is that ben lynch says that a singel mutation of 1298 is not a big deal...but i was in contact with jamie horn (you can find her on google) which follows the guidelines of dr rawling which got better after methylfolate and methylcobalamine supplementation and she was also single 1298 as me.
Which is your idea about this? and what are you actually following as therapy?